Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the Δ<i>dtlA</i> Mutant of a Marine-Derived <i>Streptomyces</i> Strain
Two new dimeric cinnamoyl lipids (CL) featuring with an unusual dearomatic carbon-bridge, named youssoufenes A2 (<b>1</b>) and A3 (<b>2</b>), were isolated from the Δ<i>dtlA</i> mutant strain of marine-derived <i>Streptomyces youssoufiensis</i> OUC6819...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/6/394 |
| _version_ | 1797485021563453440 |
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| author | Jing Liu Huayue Li Zengzhi Liu Tong Li Fei Xiao Wenli Li |
| author_facet | Jing Liu Huayue Li Zengzhi Liu Tong Li Fei Xiao Wenli Li |
| author_sort | Jing Liu |
| collection | DOAJ |
| description | Two new dimeric cinnamoyl lipids (CL) featuring with an unusual dearomatic carbon-bridge, named youssoufenes A2 (<b>1</b>) and A3 (<b>2</b>), were isolated from the Δ<i>dtlA</i> mutant strain of marine-derived <i>Streptomyces youssoufiensis</i> OUC6819. Structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses, and their absolute configurations were determined by combination of the long-range NOE-based <sup>1</sup>H-<sup>1</sup>H distance measurements and ECD calculations. Compounds <b>1</b> and <b>2</b> exhibited moderate growth inhibition against multi-drug-resistant <i>Enterococcus faecalis</i> CCARM 5172 with an MIC value of 22.2 μM. |
| first_indexed | 2024-03-09T23:12:50Z |
| format | Article |
| id | doaj.art-8d96cdf23b374b1785d9d024a1eb37ee |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T23:12:50Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-8d96cdf23b374b1785d9d024a1eb37ee2023-11-23T17:41:26ZengMDPI AGMarine Drugs1660-33972022-06-0120639410.3390/md20060394Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the Δ<i>dtlA</i> Mutant of a Marine-Derived <i>Streptomyces</i> StrainJing Liu0Huayue Li1Zengzhi Liu2Tong Li3Fei Xiao4Wenli Li5Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaTwo new dimeric cinnamoyl lipids (CL) featuring with an unusual dearomatic carbon-bridge, named youssoufenes A2 (<b>1</b>) and A3 (<b>2</b>), were isolated from the Δ<i>dtlA</i> mutant strain of marine-derived <i>Streptomyces youssoufiensis</i> OUC6819. Structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses, and their absolute configurations were determined by combination of the long-range NOE-based <sup>1</sup>H-<sup>1</sup>H distance measurements and ECD calculations. Compounds <b>1</b> and <b>2</b> exhibited moderate growth inhibition against multi-drug-resistant <i>Enterococcus faecalis</i> CCARM 5172 with an MIC value of 22.2 μM.https://www.mdpi.com/1660-3397/20/6/394cinnamoyl lipidbenzoic polyene acidmarine-derived <i>Streptomyces</i>multi-drug-resistantantibiotic |
| spellingShingle | Jing Liu Huayue Li Zengzhi Liu Tong Li Fei Xiao Wenli Li Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the Δ<i>dtlA</i> Mutant of a Marine-Derived <i>Streptomyces</i> Strain Marine Drugs cinnamoyl lipid benzoic polyene acid marine-derived <i>Streptomyces</i> multi-drug-resistant antibiotic |
| title | Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the Δ<i>dtlA</i> Mutant of a Marine-Derived <i>Streptomyces</i> Strain |
| title_full | Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the Δ<i>dtlA</i> Mutant of a Marine-Derived <i>Streptomyces</i> Strain |
| title_fullStr | Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the Δ<i>dtlA</i> Mutant of a Marine-Derived <i>Streptomyces</i> Strain |
| title_full_unstemmed | Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the Δ<i>dtlA</i> Mutant of a Marine-Derived <i>Streptomyces</i> Strain |
| title_short | Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the Δ<i>dtlA</i> Mutant of a Marine-Derived <i>Streptomyces</i> Strain |
| title_sort | youssoufenes a2 and a3 antibiotic dimeric cinnamoyl lipids from the δ i dtla i mutant of a marine derived i streptomyces i strain |
| topic | cinnamoyl lipid benzoic polyene acid marine-derived <i>Streptomyces</i> multi-drug-resistant antibiotic |
| url | https://www.mdpi.com/1660-3397/20/6/394 |
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