Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical Trachelectomy
This study aimed to assess the accuracy of predicting pelvic lymph node status using sentinel lymph node (SLN) biopsy with indocyanine green (ICG) and to examine the outcomes of SLN biopsy-guided abdominal radical trachelectomy (ART). Patients with stage IA2–IB2 cervical cancer from January 2009 to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/28/6/397 |
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| author | Naomi Harano Masaru Sakamoto Souta Fukushima Shinnosuke Iwai Yuki Koike Shingo Horikawa Kayo Suzuki Chikage Narui Kazuko Matsuoka Rinko Ozeki Keiichi Iwaya Kenji Umayahara Tadao Tanaka Aikou Okamoto |
| author_facet | Naomi Harano Masaru Sakamoto Souta Fukushima Shinnosuke Iwai Yuki Koike Shingo Horikawa Kayo Suzuki Chikage Narui Kazuko Matsuoka Rinko Ozeki Keiichi Iwaya Kenji Umayahara Tadao Tanaka Aikou Okamoto |
| author_sort | Naomi Harano |
| collection | DOAJ |
| description | This study aimed to assess the accuracy of predicting pelvic lymph node status using sentinel lymph node (SLN) biopsy with indocyanine green (ICG) and to examine the outcomes of SLN biopsy-guided abdominal radical trachelectomy (ART). Patients with stage IA2–IB2 cervical cancer from January 2009 to January 2021 were included. ICG was injected before ART and SLNs were identified, excised, and assessed intraoperatively using fast-frozen sections. Systemic pelvic lymphadenectomy was subsequently performed. The SLN detection rate, sensitivity, and false-negative rate were determined. Thirty patients desiring fertility preservation were enrolled, of whom 26 successfully completed ART and four underwent radical hysterectomies because of metastatic primary SLNs. Bilateral SLNs were identified in all patients. The sensitivity, false-negative rate, and negative predictive value were 100%, 7.7%, and 92.3%, respectively. Three (12%) patients were lost to follow-up: two relapsed and one died of tumor progression. Of the nine patients who tried to conceive after surgery, four achieved pregnancy and three delivered healthy live infants. In women with early-stage cervical cancer who desired to conserve fertility, SLN mapping with ICG had a very high detection rate, sensitivity, and low false-negative rate. SLN biopsy-guided ART is a feasible and accurate method for assessing pelvic node status. |
| first_indexed | 2024-03-10T04:21:02Z |
| format | Article |
| id | doaj.art-8d9734b9bb32422099fad42c459b6f3f |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T04:21:02Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-8d9734b9bb32422099fad42c459b6f3f2023-11-23T07:50:31ZengMDPI AGCurrent Oncology1198-00521718-77292021-11-012864709472010.3390/curroncol28060397Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical TrachelectomyNaomi Harano0Masaru Sakamoto1Souta Fukushima2Shinnosuke Iwai3Yuki Koike4Shingo Horikawa5Kayo Suzuki6Chikage Narui7Kazuko Matsuoka8Rinko Ozeki9Keiichi Iwaya10Kenji Umayahara11Tadao Tanaka12Aikou Okamoto13Department of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Pathology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Pathology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanDepartment of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, JapanThis study aimed to assess the accuracy of predicting pelvic lymph node status using sentinel lymph node (SLN) biopsy with indocyanine green (ICG) and to examine the outcomes of SLN biopsy-guided abdominal radical trachelectomy (ART). Patients with stage IA2–IB2 cervical cancer from January 2009 to January 2021 were included. ICG was injected before ART and SLNs were identified, excised, and assessed intraoperatively using fast-frozen sections. Systemic pelvic lymphadenectomy was subsequently performed. The SLN detection rate, sensitivity, and false-negative rate were determined. Thirty patients desiring fertility preservation were enrolled, of whom 26 successfully completed ART and four underwent radical hysterectomies because of metastatic primary SLNs. Bilateral SLNs were identified in all patients. The sensitivity, false-negative rate, and negative predictive value were 100%, 7.7%, and 92.3%, respectively. Three (12%) patients were lost to follow-up: two relapsed and one died of tumor progression. Of the nine patients who tried to conceive after surgery, four achieved pregnancy and three delivered healthy live infants. In women with early-stage cervical cancer who desired to conserve fertility, SLN mapping with ICG had a very high detection rate, sensitivity, and low false-negative rate. SLN biopsy-guided ART is a feasible and accurate method for assessing pelvic node status.https://www.mdpi.com/1718-7729/28/6/397sentinel lymph nodecervical cancerabdominal radical trachelectomyphotodynamic eyefertility sparing |
| spellingShingle | Naomi Harano Masaru Sakamoto Souta Fukushima Shinnosuke Iwai Yuki Koike Shingo Horikawa Kayo Suzuki Chikage Narui Kazuko Matsuoka Rinko Ozeki Keiichi Iwaya Kenji Umayahara Tadao Tanaka Aikou Okamoto Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical Trachelectomy Current Oncology sentinel lymph node cervical cancer abdominal radical trachelectomy photodynamic eye fertility sparing |
| title | Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical Trachelectomy |
| title_full | Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical Trachelectomy |
| title_fullStr | Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical Trachelectomy |
| title_full_unstemmed | Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical Trachelectomy |
| title_short | Clinical Study of Sentinel Lymph Node Detection Using Photodynamic Eye for Abdominal Radical Trachelectomy |
| title_sort | clinical study of sentinel lymph node detection using photodynamic eye for abdominal radical trachelectomy |
| topic | sentinel lymph node cervical cancer abdominal radical trachelectomy photodynamic eye fertility sparing |
| url | https://www.mdpi.com/1718-7729/28/6/397 |
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