Therapeutic Approaches for Nonalcoholic Fatty Liver Disease: Established Targets and Drugs
Xiaojing Huang,1,2 Huiling Chen,2 Song Wen,2 Meiyuan Dong,2 Ligang Zhou,2 Xinlu Yuan2 1Graduate School of Fudan University, Shanghai, People’s Republic of China; 2Department of Endocrinology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, People’s Republic of ChinaCorres...
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| Format: | Article |
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Dove Medical Press
2023-06-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/therapeutic-approaches-for-nonalcoholic-fatty-liver-disease-establishe-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797789442755264512 |
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| author | Huang X Chen H Wen S Dong M Zhou L Yuan X |
| author_facet | Huang X Chen H Wen S Dong M Zhou L Yuan X |
| author_sort | Huang X |
| collection | DOAJ |
| description | Xiaojing Huang,1,2 Huiling Chen,2 Song Wen,2 Meiyuan Dong,2 Ligang Zhou,2 Xinlu Yuan2 1Graduate School of Fudan University, Shanghai, People’s Republic of China; 2Department of Endocrinology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, People’s Republic of ChinaCorrespondence: Xinlu Yuan, Department of Endocrinology and Metabolic Diseases, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, People’s Republic of China, Email yuanxinlu1982@126.comAbstract: Nonalcoholic fatty liver disease (NAFLD), as a multisystemic disease, is the most prevalent chronic liver disease characterized by extremely complex pathogenic mechanisms and multifactorial etiology, which often develops as a consequence of obesity, metabolic syndrome. Pathophysiological mechanisms involved in the development of NAFLD include diet, obesity, insulin resistance (IR), genetic and epigenetic determinants, intestinal dysbiosis, oxidative/nitrosative stress, autophagy dysregulation, hepatic inflammation, gut-liver axis, gut microbes, impaired mitochondrial metabolism and regulation of hepatic lipid metabolism. Some of the new drugs for the treatment of NAFLD are introduced here. All of them achieve therapeutic objectives by interfering with certain pathophysiological pathways of NAFLD, including fibroblast growth factors (FGF) analogues, peroxisome proliferator-activated receptors (PPARs) agonists, glucagon-like peptide-1 (GLP-1) agonists, G protein-coupled receptors (GPCRs), sodium-glucose cotransporter-2 inhibitors (SGLT-2i), farnesoid X receptor (FXR), fatty acid synthase inhibitor (FASNi), antioxidants, etc. This review describes some pathophysiological mechanisms of NAFLD and established targets and drugs.Keywords: non-alcoholic fatty liver disease, oxidative stress, lipotoxicity, organ dysfunction, dysbiosis, new treatment modalities |
| first_indexed | 2024-03-13T01:49:43Z |
| format | Article |
| id | doaj.art-8d9ed6439b5245349fb54d4ea404a693 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-13T01:49:43Z |
| publishDate | 2023-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-8d9ed6439b5245349fb54d4ea404a6932023-07-02T19:49:17ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072023-06-01Volume 161809181984603Therapeutic Approaches for Nonalcoholic Fatty Liver Disease: Established Targets and DrugsHuang XChen HWen SDong MZhou LYuan XXiaojing Huang,1,2 Huiling Chen,2 Song Wen,2 Meiyuan Dong,2 Ligang Zhou,2 Xinlu Yuan2 1Graduate School of Fudan University, Shanghai, People’s Republic of China; 2Department of Endocrinology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, People’s Republic of ChinaCorrespondence: Xinlu Yuan, Department of Endocrinology and Metabolic Diseases, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, People’s Republic of China, Email yuanxinlu1982@126.comAbstract: Nonalcoholic fatty liver disease (NAFLD), as a multisystemic disease, is the most prevalent chronic liver disease characterized by extremely complex pathogenic mechanisms and multifactorial etiology, which often develops as a consequence of obesity, metabolic syndrome. Pathophysiological mechanisms involved in the development of NAFLD include diet, obesity, insulin resistance (IR), genetic and epigenetic determinants, intestinal dysbiosis, oxidative/nitrosative stress, autophagy dysregulation, hepatic inflammation, gut-liver axis, gut microbes, impaired mitochondrial metabolism and regulation of hepatic lipid metabolism. Some of the new drugs for the treatment of NAFLD are introduced here. All of them achieve therapeutic objectives by interfering with certain pathophysiological pathways of NAFLD, including fibroblast growth factors (FGF) analogues, peroxisome proliferator-activated receptors (PPARs) agonists, glucagon-like peptide-1 (GLP-1) agonists, G protein-coupled receptors (GPCRs), sodium-glucose cotransporter-2 inhibitors (SGLT-2i), farnesoid X receptor (FXR), fatty acid synthase inhibitor (FASNi), antioxidants, etc. This review describes some pathophysiological mechanisms of NAFLD and established targets and drugs.Keywords: non-alcoholic fatty liver disease, oxidative stress, lipotoxicity, organ dysfunction, dysbiosis, new treatment modalitieshttps://www.dovepress.com/therapeutic-approaches-for-nonalcoholic-fatty-liver-disease-establishe-peer-reviewed-fulltext-article-DMSOnon-alcoholic fatty liver diseaseoxidative stresslipotoxicityorgan dysfunctiondysbiosisnew treatment modalities |
| spellingShingle | Huang X Chen H Wen S Dong M Zhou L Yuan X Therapeutic Approaches for Nonalcoholic Fatty Liver Disease: Established Targets and Drugs Diabetes, Metabolic Syndrome and Obesity non-alcoholic fatty liver disease oxidative stress lipotoxicity organ dysfunction dysbiosis new treatment modalities |
| title | Therapeutic Approaches for Nonalcoholic Fatty Liver Disease: Established Targets and Drugs |
| title_full | Therapeutic Approaches for Nonalcoholic Fatty Liver Disease: Established Targets and Drugs |
| title_fullStr | Therapeutic Approaches for Nonalcoholic Fatty Liver Disease: Established Targets and Drugs |
| title_full_unstemmed | Therapeutic Approaches for Nonalcoholic Fatty Liver Disease: Established Targets and Drugs |
| title_short | Therapeutic Approaches for Nonalcoholic Fatty Liver Disease: Established Targets and Drugs |
| title_sort | therapeutic approaches for nonalcoholic fatty liver disease established targets and drugs |
| topic | non-alcoholic fatty liver disease oxidative stress lipotoxicity organ dysfunction dysbiosis new treatment modalities |
| url | https://www.dovepress.com/therapeutic-approaches-for-nonalcoholic-fatty-liver-disease-establishe-peer-reviewed-fulltext-article-DMSO |
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