C-terminal extension of the yeast mitochondrial DNA polymerase determines the balance between synthesis and degradation.

C-terminal extension of the yeast mitochondrial DNA polymerase determines the balance between synthesis and degradation.

Saccharomyces cerevisiae mitochondrial DNA polymerase (Mip1) contains a C-terminal extension (CTE) of 279 amino acid residues. The CTE is required for mitochondrial DNA maintenance in yeast but is absent in higher eukaryotes. Here we use recombinant Mip1 C-terminal deletion mutants to investigate fu...

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Bibliographic Details
Main Authors: Katrin Viikov, Olga Jasnovidova, Tiina Tamm, Juhan Sedman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3303844?pdf=render

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