Intratumoral Distribution and pH-Dependent Drug Release of High Molecular Weight HPMA Copolymer Drug Conjugates Strongly Depend on Specific Tumor Substructure and Microenvironment

Intratumoral Distribution and pH-Dependent Drug Release of High Molecular Weight HPMA Copolymer Drug Conjugates Strongly Depend on Specific Tumor Substructure and Microenvironment

Stimulus-sensitive polymer drug conjugates based on high molecular weight N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers carrying doxorubicin via a pH-dependent cleavable bond (pHPMA-Dox) were previously shown to be able to overcome multi-drug resistance. Nevertheless, a tumor type dependent d...

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Bibliographic Details
Main Authors: Anne-Kathrin Noack, Henrike Lucas, Petr Chytil, Tomáš Etrych, Karsten Mäder, Thomas Mueller
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
HPMA copolymer
polymer drug conjugates
pH-sensitive drug release
tumor microenvironment
chemotherapy resistance
Online Access:https://www.mdpi.com/1422-0067/21/17/6029

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