Mutation and Lineage Analysis of DNMT3A in BCR-ABL1-negative Chronic Myeloproliferative Neoplasms

Mutation and Lineage Analysis of DNMT3A in BCR-ABL1-negative Chronic Myeloproliferative Neoplasms

In addition to the JAK2 V617F mutation, somatic mutation in DNMT3A has been described in BCL-ABL1-negative myeloproliferative neoplasms (MPNs). We have screened for DNMT3A exon 23 mutations in 130 adult Taiwanese patients with chronic phase myeloproliferative neoplasms. Only one somatic DNMT3A R882H...

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Main Authors: Huan-Chau Lin, Shu-Ching Wang, Caleb Gon-Shen Chen, Ming-Chih Chang, Wei-Ting Wang, Nai-Wen Su, Hung-I Cheng, Johnson Lin, Yi-Fang Chang, Ruey-Kuen Hsieh, Chien-Chung Chang, Yuchi Hwang, Ken-Hong Lim, Yuan-Yeh Kuo
Format: Article
Language:English
Published: Taiwan Society of Geriatric Emergency and Critical Medicine (TSGECM) 2013-09-01
Series:International Journal of Gerontology
Subjects:
DNMT3A
mutation
myeloproliferative neoplasm
Online Access:http://www.sciencedirect.com/science/article/pii/S1873959813000069

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