Tumor microvessel density–associated mast cells in canine nodal lymphoma
Objective: Mast cells are associated in angiogenesis in various human and animal neoplasms. However, association of mast cells with tumor microvessel density in canine lymphoma was not previously documented. The objective of the study is to determine if mast cells are increased in canine nodal lymph...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-11-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/2050312114559575 |
| _version_ | 1819169080577359872 |
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| author | Moges Woldemeskel Elizabeth Mann Lisa Whittington |
| author_facet | Moges Woldemeskel Elizabeth Mann Lisa Whittington |
| author_sort | Moges Woldemeskel |
| collection | DOAJ |
| description | Objective: Mast cells are associated in angiogenesis in various human and animal neoplasms. However, association of mast cells with tumor microvessel density in canine lymphoma was not previously documented. The objective of the study is to determine if mast cells are increased in canine nodal lymphomas and to evaluate their correlation with tumor microvessel density and grading of lymphomas. Methods: Nodal lymphomas from 33 dogs were studied and compared with nonneoplastic lymph nodes from 6 dogs as control. Mast cell count was made on Toluidine blue stained sections. Immunohistochemistry using antibody against Factor VIII was employed to visualize and determine microvessel density. Results: The mast cell count in lymphoma (2.95 ± 2.4) was significantly higher ( p < 0.05) than that in the control (0.83 ± 0.3) and was positively correlated with tumor microvessel density ( r = 0.44, p = 0.009). Significant difference was not observed in mast cell count and tumor microvessel density among different gradings of lymphomas. Conclusions: Mast cells are associated with tumor microvessel density in canine nodal lymphoma with no significant difference among gradings of lymphomas. Mast cells may play an important role in development of canine nodal lymphomas. Further detailed investigation on the role of mast cells as important part of tumor microenvironment in canine nodal lymphomas is recommended. |
| first_indexed | 2024-12-22T19:13:49Z |
| format | Article |
| id | doaj.art-8da548613c214b1daeed75858c86a8cc |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-12-22T19:13:49Z |
| publishDate | 2014-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-8da548613c214b1daeed75858c86a8cc2022-12-21T18:15:35ZengSAGE PublishingSAGE Open Medicine2050-31212014-11-01210.1177/205031211455957510.1177_2050312114559575Tumor microvessel density–associated mast cells in canine nodal lymphomaMoges WoldemeskelElizabeth MannLisa WhittingtonObjective: Mast cells are associated in angiogenesis in various human and animal neoplasms. However, association of mast cells with tumor microvessel density in canine lymphoma was not previously documented. The objective of the study is to determine if mast cells are increased in canine nodal lymphomas and to evaluate their correlation with tumor microvessel density and grading of lymphomas. Methods: Nodal lymphomas from 33 dogs were studied and compared with nonneoplastic lymph nodes from 6 dogs as control. Mast cell count was made on Toluidine blue stained sections. Immunohistochemistry using antibody against Factor VIII was employed to visualize and determine microvessel density. Results: The mast cell count in lymphoma (2.95 ± 2.4) was significantly higher ( p < 0.05) than that in the control (0.83 ± 0.3) and was positively correlated with tumor microvessel density ( r = 0.44, p = 0.009). Significant difference was not observed in mast cell count and tumor microvessel density among different gradings of lymphomas. Conclusions: Mast cells are associated with tumor microvessel density in canine nodal lymphoma with no significant difference among gradings of lymphomas. Mast cells may play an important role in development of canine nodal lymphomas. Further detailed investigation on the role of mast cells as important part of tumor microenvironment in canine nodal lymphomas is recommended.https://doi.org/10.1177/2050312114559575 |
| spellingShingle | Moges Woldemeskel Elizabeth Mann Lisa Whittington Tumor microvessel density–associated mast cells in canine nodal lymphoma SAGE Open Medicine |
| title | Tumor microvessel density–associated mast cells in canine nodal lymphoma |
| title_full | Tumor microvessel density–associated mast cells in canine nodal lymphoma |
| title_fullStr | Tumor microvessel density–associated mast cells in canine nodal lymphoma |
| title_full_unstemmed | Tumor microvessel density–associated mast cells in canine nodal lymphoma |
| title_short | Tumor microvessel density–associated mast cells in canine nodal lymphoma |
| title_sort | tumor microvessel density associated mast cells in canine nodal lymphoma |
| url | https://doi.org/10.1177/2050312114559575 |
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