Hydatidiform mole: validity of the registration in the Danish National Patient Registry, the Danish Cancer Registry, and the Danish Pathology Registry 1999–2009
Helle Lund,1,2 Mogens Vyberg,1,2 Helle Højmark Eriksen,3 Anni Grove,1 Annette Østergaard Jensen,1 Lone Sunde4,5 1Institute of Pathology, Aalborg University Hospital, Aalborg, Denmark; 2Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; 3Unit of Epidemiology...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-09-01
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| Series: | Clinical Epidemiology |
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| Online Access: | https://www.dovepress.com/hydatidiform-mole-validity-of-the-registration-in-the-danish-national--peer-reviewed-article-CLEP |
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| author | Lund H Vyberg M Eriksen HH Grove A Jensen AØ Sunde L |
| author_facet | Lund H Vyberg M Eriksen HH Grove A Jensen AØ Sunde L |
| author_sort | Lund H |
| collection | DOAJ |
| description | Helle Lund,1,2 Mogens Vyberg,1,2 Helle Højmark Eriksen,3 Anni Grove,1 Annette Østergaard Jensen,1 Lone Sunde4,5 1Institute of Pathology, Aalborg University Hospital, Aalborg, Denmark; 2Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; 3Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark; 4Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark; 5Department of Biomedicine, Aarhus University, Aarhus, Denmark Purpose: To examine the validity of registration of hydatidiform mole (HM) in the Danish National Patient Registry (NPR), the Danish Cancer Registry (DCR), and the Danish Pathology Registry (DPR).Patients and methods: We selected women registered with a first-time HM code in NPR, DCR, and DPR from 1999 to 2009. We found most women registered in DPR. For a random sample of women registered in DPR, the coding was validated by comparing with the pathology report. Completeness and positive predictive value (PPV) of registration with an HM code in NPR and DCR were calculated using DPR as the reference. Details of women registered in NPR or DCR, but not in DPR, were scrutinized.Results: In NPR and DPR, 1,520 women were identified in total; 1,057 (70%) were found in both registries, 65 (4%) only in NPR, and 398 (26%) only in DPR. In DCR and DPR, 1,498 women were identified in total; 1,174 (78%) in both registries, 47 (3%) only in DCR, and 277 (19%) only in DPR. For 149/150 randomly selected women registered with an HM code in DPR (99%), the pathology report was consistent with the diagnosis of HM. Completeness of NPR was 73% (95% CI: 70%–75%) and PPV was 94% (95% CI: 93%–95%). Completeness of DCR was 72% (95% CI: 69%–75%) in 1999–2003 and 90% (95% CI: 87%–92%) in 2004–2009. PPV of DCR was 96% (95% CI: 95%–97%) throughout the period.Conclusion: Validation of registry data is important before using these. For research on the number of HMs in Denmark, DPR is the most valid data source. NPR and DCR appear to be equally valid before 2004. However, for research after 2004, DCR should be preferred rather than NPR. Keywords: epidemiology, completeness, positive predictive value, complete hydatidiform mole, partial hydatidiform mole, agreement |
| first_indexed | 2024-12-10T07:34:11Z |
| format | Article |
| id | doaj.art-8da8fe4fc4b447fa9cd44938d30b0152 |
| institution | Directory Open Access Journal |
| issn | 1179-1349 |
| language | English |
| last_indexed | 2024-12-10T07:34:11Z |
| publishDate | 2018-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Epidemiology |
| spelling | doaj.art-8da8fe4fc4b447fa9cd44938d30b01522022-12-22T01:57:28ZengDove Medical PressClinical Epidemiology1179-13492018-09-01Volume 101223123140700Hydatidiform mole: validity of the registration in the Danish National Patient Registry, the Danish Cancer Registry, and the Danish Pathology Registry 1999–2009Lund HVyberg MEriksen HHGrove AJensen AØSunde LHelle Lund,1,2 Mogens Vyberg,1,2 Helle Højmark Eriksen,3 Anni Grove,1 Annette Østergaard Jensen,1 Lone Sunde4,5 1Institute of Pathology, Aalborg University Hospital, Aalborg, Denmark; 2Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; 3Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark; 4Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark; 5Department of Biomedicine, Aarhus University, Aarhus, Denmark Purpose: To examine the validity of registration of hydatidiform mole (HM) in the Danish National Patient Registry (NPR), the Danish Cancer Registry (DCR), and the Danish Pathology Registry (DPR).Patients and methods: We selected women registered with a first-time HM code in NPR, DCR, and DPR from 1999 to 2009. We found most women registered in DPR. For a random sample of women registered in DPR, the coding was validated by comparing with the pathology report. Completeness and positive predictive value (PPV) of registration with an HM code in NPR and DCR were calculated using DPR as the reference. Details of women registered in NPR or DCR, but not in DPR, were scrutinized.Results: In NPR and DPR, 1,520 women were identified in total; 1,057 (70%) were found in both registries, 65 (4%) only in NPR, and 398 (26%) only in DPR. In DCR and DPR, 1,498 women were identified in total; 1,174 (78%) in both registries, 47 (3%) only in DCR, and 277 (19%) only in DPR. For 149/150 randomly selected women registered with an HM code in DPR (99%), the pathology report was consistent with the diagnosis of HM. Completeness of NPR was 73% (95% CI: 70%–75%) and PPV was 94% (95% CI: 93%–95%). Completeness of DCR was 72% (95% CI: 69%–75%) in 1999–2003 and 90% (95% CI: 87%–92%) in 2004–2009. PPV of DCR was 96% (95% CI: 95%–97%) throughout the period.Conclusion: Validation of registry data is important before using these. For research on the number of HMs in Denmark, DPR is the most valid data source. NPR and DCR appear to be equally valid before 2004. However, for research after 2004, DCR should be preferred rather than NPR. Keywords: epidemiology, completeness, positive predictive value, complete hydatidiform mole, partial hydatidiform mole, agreementhttps://www.dovepress.com/hydatidiform-mole-validity-of-the-registration-in-the-danish-national--peer-reviewed-article-CLEPEpidemiologycompletenesspositive predictive valuecomplete hydatidiform molepartial hydatidiform molevalidity |
| spellingShingle | Lund H Vyberg M Eriksen HH Grove A Jensen AØ Sunde L Hydatidiform mole: validity of the registration in the Danish National Patient Registry, the Danish Cancer Registry, and the Danish Pathology Registry 1999–2009 Clinical Epidemiology Epidemiology completeness positive predictive value complete hydatidiform mole partial hydatidiform mole validity |
| title | Hydatidiform mole: validity of the registration in the Danish National Patient Registry, the Danish Cancer Registry, and the Danish Pathology Registry 1999–2009 |
| title_full | Hydatidiform mole: validity of the registration in the Danish National Patient Registry, the Danish Cancer Registry, and the Danish Pathology Registry 1999–2009 |
| title_fullStr | Hydatidiform mole: validity of the registration in the Danish National Patient Registry, the Danish Cancer Registry, and the Danish Pathology Registry 1999–2009 |
| title_full_unstemmed | Hydatidiform mole: validity of the registration in the Danish National Patient Registry, the Danish Cancer Registry, and the Danish Pathology Registry 1999–2009 |
| title_short | Hydatidiform mole: validity of the registration in the Danish National Patient Registry, the Danish Cancer Registry, and the Danish Pathology Registry 1999–2009 |
| title_sort | hydatidiform mole validity of the registration in the danish national patient registry the danish cancer registry and the danish pathology registry 1999 ndash 2009 |
| topic | Epidemiology completeness positive predictive value complete hydatidiform mole partial hydatidiform mole validity |
| url | https://www.dovepress.com/hydatidiform-mole-validity-of-the-registration-in-the-danish-national--peer-reviewed-article-CLEP |
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