Investigation on Filaments for 3D Printing of Nasal Septum Cartilage Implant
Septoplasty is a widely used method in treating deviated septum. Although it is successfully implemented, there are problems with excessive bleeding, septal perforation, or infections. The use of anatomically shaped implants could help overcome these problems. This paper focuses on assessing the pos...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/16/9/3534 |
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| author | Przemysław Gnatowski Karolina Gwizdała Agnieszka Kurdyn Andrzej Skorek Ewa Augustin Justyna Kucińska-Lipka |
| author_facet | Przemysław Gnatowski Karolina Gwizdała Agnieszka Kurdyn Andrzej Skorek Ewa Augustin Justyna Kucińska-Lipka |
| author_sort | Przemysław Gnatowski |
| collection | DOAJ |
| description | Septoplasty is a widely used method in treating deviated septum. Although it is successfully implemented, there are problems with excessive bleeding, septal perforation, or infections. The use of anatomically shaped implants could help overcome these problems. This paper focuses on assessing the possibility of the usage of a nasal septum cartilage implant 3D printed from various market-available filaments. Five different types of laments were used, two of which claim to be suitable for medical use. A combination of modeling, mechanical (bending, compression), structural (FTIR), thermal (DSC, MFR), surface (contact angle), microscopic (optical), degradation (2 M HCl, 5 M NaOH, and 0.01 M PBS), printability, and cell viability (MTT) analyses allowed us to assess the suitability of materials for manufacturing implants. Bioflex had the most applicable properties among the tested materials, but despite the overall good performance, cell viability studies showed toxicity of the material in MTT test. The results of the study show that selected filaments were not suitable for nasal cartilage implants. The poor cell viability of Bioflex could be improved by surface modification. Further research on biocompatible elastic materials for 3D printing is needed either by the synthesis of new materials or by modifying existing ones. |
| first_indexed | 2024-03-11T04:13:20Z |
| format | Article |
| id | doaj.art-8daa38ab27314d81adb514ea1af2cf47 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-11T04:13:20Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-8daa38ab27314d81adb514ea1af2cf472023-11-17T23:17:23ZengMDPI AGMaterials1996-19442023-05-01169353410.3390/ma16093534Investigation on Filaments for 3D Printing of Nasal Septum Cartilage ImplantPrzemysław Gnatowski0Karolina Gwizdała1Agnieszka Kurdyn2Andrzej Skorek3Ewa Augustin4Justyna Kucińska-Lipka5Department of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233 Gdańsk, PolandDepartment of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233 Gdańsk, PolandDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233 Gdańsk, PolandDepartment of Otolaryngology, Faculty of Medicine, Medical University of Gdańsk, Marii Skłodowskiej-Curie Str. 3a, 80-210 Gdańsk, PolandDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233 Gdańsk, PolandDepartment of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233 Gdańsk, PolandSeptoplasty is a widely used method in treating deviated septum. Although it is successfully implemented, there are problems with excessive bleeding, septal perforation, or infections. The use of anatomically shaped implants could help overcome these problems. This paper focuses on assessing the possibility of the usage of a nasal septum cartilage implant 3D printed from various market-available filaments. Five different types of laments were used, two of which claim to be suitable for medical use. A combination of modeling, mechanical (bending, compression), structural (FTIR), thermal (DSC, MFR), surface (contact angle), microscopic (optical), degradation (2 M HCl, 5 M NaOH, and 0.01 M PBS), printability, and cell viability (MTT) analyses allowed us to assess the suitability of materials for manufacturing implants. Bioflex had the most applicable properties among the tested materials, but despite the overall good performance, cell viability studies showed toxicity of the material in MTT test. The results of the study show that selected filaments were not suitable for nasal cartilage implants. The poor cell viability of Bioflex could be improved by surface modification. Further research on biocompatible elastic materials for 3D printing is needed either by the synthesis of new materials or by modifying existing ones.https://www.mdpi.com/1996-1944/16/9/35343D printingnasal septumnasal cartilagedeviated septumpolyurethane |
| spellingShingle | Przemysław Gnatowski Karolina Gwizdała Agnieszka Kurdyn Andrzej Skorek Ewa Augustin Justyna Kucińska-Lipka Investigation on Filaments for 3D Printing of Nasal Septum Cartilage Implant Materials 3D printing nasal septum nasal cartilage deviated septum polyurethane |
| title | Investigation on Filaments for 3D Printing of Nasal Septum Cartilage Implant |
| title_full | Investigation on Filaments for 3D Printing of Nasal Septum Cartilage Implant |
| title_fullStr | Investigation on Filaments for 3D Printing of Nasal Septum Cartilage Implant |
| title_full_unstemmed | Investigation on Filaments for 3D Printing of Nasal Septum Cartilage Implant |
| title_short | Investigation on Filaments for 3D Printing of Nasal Septum Cartilage Implant |
| title_sort | investigation on filaments for 3d printing of nasal septum cartilage implant |
| topic | 3D printing nasal septum nasal cartilage deviated septum polyurethane |
| url | https://www.mdpi.com/1996-1944/16/9/3534 |
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