Associations between triglyceride-glucose index and different hypertension subtypes: A population-based study in China
BackgroundAbnormal glycolipid metabolism plays a crucial role in hypertension. While an elevated triglyceride-glucose (TyG) index has been recognized as a risk factor for developing hypertension, the associations between the TyG index and different hypertension subtypes, namely, isolated systolic hy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.901180/full |
| _version_ | 1811217438176444416 |
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| author | Qian Cai Qian Cai Cathleen Y. Xing Jiang Zhu Ying Wang Fanghong Lu Jie Peng Jie Peng |
| author_facet | Qian Cai Qian Cai Cathleen Y. Xing Jiang Zhu Ying Wang Fanghong Lu Jie Peng Jie Peng |
| author_sort | Qian Cai |
| collection | DOAJ |
| description | BackgroundAbnormal glycolipid metabolism plays a crucial role in hypertension. While an elevated triglyceride-glucose (TyG) index has been recognized as a risk factor for developing hypertension, the associations between the TyG index and different hypertension subtypes, namely, isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic-diastolic hypertension (SDH), remain unclear. This study was designed to investigate the associations between the TyG index and hypertension subtypes in a general Chinese population.Materials and methodsIn a sample of 16,793 participants from Shandong Province, China, multivariate logistic regression analyses were performed to examine the associations between the TyG index and different hypertension subtypes. Loess smooth curves were fitted to visualize the trends. Stratified analyses were conducted to further assess the potential interactions in the associations between the TyG index and different hypertension subtypes.ResultsA higher TyG index was associated with an increased odds of having IDH (OR = 2.94, 95% CI: 1.66–5.23) and SDH (OR = 1.82, 95% CI: 1.33–2.49), whereas no apparent relationship was observed between TyG index and ISH. With respect to sex, the effect of TyG index on having IDH and SDH was significant in women, but not in men. Participants with lower lipid profiles and glucose levels demonstrated a stronger strength of association between the TyG index and IDH as compared with the TyG index-SDH association. Stratified analysis showed that participants with a higher TyG index were more than 3 times more likely to have IDH and SDH among persons aged 18–42 years. Significant interactions were observed between TyG index and sex, age, and high-density lipoprotein cholesterol (HDL-C) in the SDH group, and a significant interaction was also found between TyG index and body mass index (BMI) in the ISH group.ConclusionTriglyceride-glucose index may potentially serve as a novel indicator for IDH and SDH. Our findings could also inform the development and implementation of targeted screening for hypertension. |
| first_indexed | 2024-04-12T06:53:52Z |
| format | Article |
| id | doaj.art-8dab9d9b3d5140e9a3944653c497482c |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T06:53:52Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-8dab9d9b3d5140e9a3944653c497482c2022-12-22T03:43:12ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-08-01910.3389/fcvm.2022.901180901180Associations between triglyceride-glucose index and different hypertension subtypes: A population-based study in ChinaQian Cai0Qian Cai1Cathleen Y. Xing2Jiang Zhu3Ying Wang4Fanghong Lu5Jie Peng6Jie Peng7Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, ChinaKey Laboratory of Cardiovascular Proteomics of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaTuberculosis Control and Prevention Program, San Francisco Department of Public Health, San Francisco, CA, United StatesDepartment of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Cheeloo College of Medicine, Qilu Hospital of Shandong University, Jinan, ChinaCardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, ChinaKey Laboratory of Cardiovascular Proteomics of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaBackgroundAbnormal glycolipid metabolism plays a crucial role in hypertension. While an elevated triglyceride-glucose (TyG) index has been recognized as a risk factor for developing hypertension, the associations between the TyG index and different hypertension subtypes, namely, isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic-diastolic hypertension (SDH), remain unclear. This study was designed to investigate the associations between the TyG index and hypertension subtypes in a general Chinese population.Materials and methodsIn a sample of 16,793 participants from Shandong Province, China, multivariate logistic regression analyses were performed to examine the associations between the TyG index and different hypertension subtypes. Loess smooth curves were fitted to visualize the trends. Stratified analyses were conducted to further assess the potential interactions in the associations between the TyG index and different hypertension subtypes.ResultsA higher TyG index was associated with an increased odds of having IDH (OR = 2.94, 95% CI: 1.66–5.23) and SDH (OR = 1.82, 95% CI: 1.33–2.49), whereas no apparent relationship was observed between TyG index and ISH. With respect to sex, the effect of TyG index on having IDH and SDH was significant in women, but not in men. Participants with lower lipid profiles and glucose levels demonstrated a stronger strength of association between the TyG index and IDH as compared with the TyG index-SDH association. Stratified analysis showed that participants with a higher TyG index were more than 3 times more likely to have IDH and SDH among persons aged 18–42 years. Significant interactions were observed between TyG index and sex, age, and high-density lipoprotein cholesterol (HDL-C) in the SDH group, and a significant interaction was also found between TyG index and body mass index (BMI) in the ISH group.ConclusionTriglyceride-glucose index may potentially serve as a novel indicator for IDH and SDH. Our findings could also inform the development and implementation of targeted screening for hypertension.https://www.frontiersin.org/articles/10.3389/fcvm.2022.901180/fullTyG indexhypertensioncross-sectional studiesISHIDHSDH |
| spellingShingle | Qian Cai Qian Cai Cathleen Y. Xing Jiang Zhu Ying Wang Fanghong Lu Jie Peng Jie Peng Associations between triglyceride-glucose index and different hypertension subtypes: A population-based study in China Frontiers in Cardiovascular Medicine TyG index hypertension cross-sectional studies ISH IDH SDH |
| title | Associations between triglyceride-glucose index and different hypertension subtypes: A population-based study in China |
| title_full | Associations between triglyceride-glucose index and different hypertension subtypes: A population-based study in China |
| title_fullStr | Associations between triglyceride-glucose index and different hypertension subtypes: A population-based study in China |
| title_full_unstemmed | Associations between triglyceride-glucose index and different hypertension subtypes: A population-based study in China |
| title_short | Associations between triglyceride-glucose index and different hypertension subtypes: A population-based study in China |
| title_sort | associations between triglyceride glucose index and different hypertension subtypes a population based study in china |
| topic | TyG index hypertension cross-sectional studies ISH IDH SDH |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.901180/full |
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