Insulin Hot-Spot Analogs Formed with <i>N</i>-Methylated Amino Acid Residues Inhibit Aggregation of Native Hormone

Insulin Hot-Spot Analogs Formed with <i>N</i>-Methylated Amino Acid Residues Inhibit Aggregation of Native Hormone

In this study, <i>N</i>-methylated analogs of hot-spots of insulin were designed and synthesized, in the expectation that they would inhibit the aggregation of both insulin hot-spots and the entire hormone. Synthesis of insulin &#8220;amyloidogenic&#8221; analogs containing <i...

Full description

Bibliographic Details
Main Authors: Monika Swiontek, Joanna Wasko, Justyna Fraczyk, Krystian Galecki, Zbigniew J. Kaminski, Beata Kolesinska
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molecules
Subjects:
inhibition of insulin aggregation
aggregation
<i>n</i>-methylated analogs of insulin hot-spots
microwave-assisted solid-phase peptide synthesis
triazine coupling reagent
Online Access:https://www.mdpi.com/1420-3049/24/20/3706

Similar Items

Similar Items