Origin of imported SARS-CoV-2 strains in The Gambia identified from whole genome sequences.
The SARS-CoV-2 disease, first detected in Wuhan, China, in December 2019 has become a global pandemic and is causing an unprecedented burden on health care systems and the economy globally. While the travel history of index cases may suggest the origin of infection, phylogenetic analysis of isolated...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0241942 |
| _version_ | 1797867536734224384 |
|---|---|
| author | Abdoulie Kanteh Jarra Manneh Sona Jabang Mariama A Kujabi Bakary Sanyang Mary A Oboh Abdoulie Bojang Haruna S Jallow Davis Nwakanma Ousman Secka Anna Roca Alfred Amambua-Ngwa Martin Antonio Ignatius Baldeh Karen Forrest Ahmadou Lamin Samateh Umberto D'Alessandro Abdul Karim Sesay |
| author_facet | Abdoulie Kanteh Jarra Manneh Sona Jabang Mariama A Kujabi Bakary Sanyang Mary A Oboh Abdoulie Bojang Haruna S Jallow Davis Nwakanma Ousman Secka Anna Roca Alfred Amambua-Ngwa Martin Antonio Ignatius Baldeh Karen Forrest Ahmadou Lamin Samateh Umberto D'Alessandro Abdul Karim Sesay |
| author_sort | Abdoulie Kanteh |
| collection | DOAJ |
| description | The SARS-CoV-2 disease, first detected in Wuhan, China, in December 2019 has become a global pandemic and is causing an unprecedented burden on health care systems and the economy globally. While the travel history of index cases may suggest the origin of infection, phylogenetic analysis of isolated strains from these cases and contacts will increase the understanding and link between local transmission and other global populations. The objective of this analysis was to provide genomic data on the first six cases of SARS-CoV-2 in The Gambia and to determine the source of infection. This ultimately provide baseline data for subsequent local transmission and contribute genomic diversity information towards local and global data. Our analysis has shown that the SARS-CoV-2 virus identified in The Gambia are of European and Asian origin and sequenced data matched patients' travel history. In addition, we were able to show that two COVID-19 positive cases travelling in the same flight had different strains of SARS-CoV-2. Although whole genome sequencing (WGS) data is still limited in sub-Saharan Africa, this approach has proven to be a highly sensitive, specific and confirmatory tool for SARS-CoV-2 detection. |
| first_indexed | 2024-04-09T23:42:51Z |
| format | Article |
| id | doaj.art-8dadd80cf0fb452584f3a520a11d0bde |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T23:42:51Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8dadd80cf0fb452584f3a520a11d0bde2023-03-18T05:32:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01168e024194210.1371/journal.pone.0241942Origin of imported SARS-CoV-2 strains in The Gambia identified from whole genome sequences.Abdoulie KantehJarra MannehSona JabangMariama A KujabiBakary SanyangMary A ObohAbdoulie BojangHaruna S JallowDavis NwakanmaOusman SeckaAnna RocaAlfred Amambua-NgwaMartin AntonioIgnatius BaldehKaren ForrestAhmadou Lamin SamatehUmberto D'AlessandroAbdul Karim SesayThe SARS-CoV-2 disease, first detected in Wuhan, China, in December 2019 has become a global pandemic and is causing an unprecedented burden on health care systems and the economy globally. While the travel history of index cases may suggest the origin of infection, phylogenetic analysis of isolated strains from these cases and contacts will increase the understanding and link between local transmission and other global populations. The objective of this analysis was to provide genomic data on the first six cases of SARS-CoV-2 in The Gambia and to determine the source of infection. This ultimately provide baseline data for subsequent local transmission and contribute genomic diversity information towards local and global data. Our analysis has shown that the SARS-CoV-2 virus identified in The Gambia are of European and Asian origin and sequenced data matched patients' travel history. In addition, we were able to show that two COVID-19 positive cases travelling in the same flight had different strains of SARS-CoV-2. Although whole genome sequencing (WGS) data is still limited in sub-Saharan Africa, this approach has proven to be a highly sensitive, specific and confirmatory tool for SARS-CoV-2 detection.https://doi.org/10.1371/journal.pone.0241942 |
| spellingShingle | Abdoulie Kanteh Jarra Manneh Sona Jabang Mariama A Kujabi Bakary Sanyang Mary A Oboh Abdoulie Bojang Haruna S Jallow Davis Nwakanma Ousman Secka Anna Roca Alfred Amambua-Ngwa Martin Antonio Ignatius Baldeh Karen Forrest Ahmadou Lamin Samateh Umberto D'Alessandro Abdul Karim Sesay Origin of imported SARS-CoV-2 strains in The Gambia identified from whole genome sequences. PLoS ONE |
| title | Origin of imported SARS-CoV-2 strains in The Gambia identified from whole genome sequences. |
| title_full | Origin of imported SARS-CoV-2 strains in The Gambia identified from whole genome sequences. |
| title_fullStr | Origin of imported SARS-CoV-2 strains in The Gambia identified from whole genome sequences. |
| title_full_unstemmed | Origin of imported SARS-CoV-2 strains in The Gambia identified from whole genome sequences. |
| title_short | Origin of imported SARS-CoV-2 strains in The Gambia identified from whole genome sequences. |
| title_sort | origin of imported sars cov 2 strains in the gambia identified from whole genome sequences |
| url | https://doi.org/10.1371/journal.pone.0241942 |
| work_keys_str_mv | AT abdouliekanteh originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT jarramanneh originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT sonajabang originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT mariamaakujabi originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT bakarysanyang originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT maryaoboh originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT abdouliebojang originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT harunasjallow originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT davisnwakanma originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT ousmansecka originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT annaroca originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT alfredamambuangwa originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT martinantonio originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT ignatiusbaldeh originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT karenforrest originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT ahmadoulaminsamateh originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT umbertodalessandro originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences AT abdulkarimsesay originofimportedsarscov2strainsinthegambiaidentifiedfromwholegenomesequences |