Effect of Platelet Parameters on Linezolid-Related Thrombocytopenia in Hospitalized Patients
Lu Zhang, Yan Yan, Ru Liao, Haiyan Dong Department of Pharmacy, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaCorrespondence: Haiyan Dong, Department of Pharmacy, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-09-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/effect-of-platelet-parameters-on-linezolid-related-thrombocytopenia-in-peer-reviewed-fulltext-article-IDR |
| _version_ | 1827818254617280512 |
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| author | Zhang L Yan Y Liao R Dong H |
| author_facet | Zhang L Yan Y Liao R Dong H |
| author_sort | Zhang L |
| collection | DOAJ |
| description | Lu Zhang, Yan Yan, Ru Liao, Haiyan Dong Department of Pharmacy, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaCorrespondence: Haiyan Dong, Department of Pharmacy, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of China, Tel/Fax +86-29-85323508, Email batistuta28@126.comBackground: Linezolid-induced thrombocytopenia incidence varies considerably. Linezolid-related thrombocytopenia in patients has received few studies which have investigated risk factors including platelet parameters except for platelet counts. The study aims to analyze the effect of platelet parameters, including mean platelet volume and platelet large cell ratio, on linezolid-related thrombocytopenia in patients.Methods: The effect of platelet parameters on linezolid-related thrombocytopenia was identified by univariate and multivariate logistic regressions. A Kaplan–Meier survival analysis was carried out to compare the survival of patients who developed linezolid-related thrombocytopenia with patients who did not.Results: Thrombocytopenia occurred at a rate of 41.5% (66/159) after linezolid therapy in hospitalized patients. Platelet parameters, including the difference in mean platelet volume (MPV/fL=0.08 (− 1.2– 0.9)vs-0.5 (− 1.5– 0.3), (OR, 0.459; P = 0.001), the difference in platelet large cell ratio (PLCR/fL=0.9 (− 5.1– 6.2)vs-3.8 (− 8.6– 2.4), (OR, 1.156; P = 0.001), baseline platelet counts (OR, 0.995; P = 0.006) and duration of linezolid therapy≥ 10d (OR, 1.346; P = 0.007), were significantly associated with linezolid-related thrombocytopenia in hospitalized patients. In addition, other risk factors which also are associated with linezolid-related thrombocytopenia include baseline red blood cells, co-medication with parecoxib and co-medication with caspofungin. Accumulated in-hospital mortality of patients with thrombocytopenia was significantly higher than that of patients without thrombocytopenia during linezolid treatment (19.7% vs 8.6%, P = 0.003).Conclusion: The difference in mean platelet volume, the difference in large platelet ratio, baseline platelet counts and duration of linezolid therapy≥ 10d significantly affected the development of linezolid-related thrombocytopenia in hospitalized patients.Keywords: linezolid, platelet parameters, thrombocytopenia, risk factors |
| first_indexed | 2024-03-12T00:45:16Z |
| format | Article |
| id | doaj.art-8dae234aad2947d18fea861411edadb4 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-03-12T00:45:16Z |
| publishDate | 2023-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-8dae234aad2947d18fea861411edadb42023-09-14T19:09:01ZengDove Medical PressInfection and Drug Resistance1178-69732023-09-01Volume 166145615486623Effect of Platelet Parameters on Linezolid-Related Thrombocytopenia in Hospitalized PatientsZhang LYan YLiao RDong HLu Zhang, Yan Yan, Ru Liao, Haiyan Dong Department of Pharmacy, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaCorrespondence: Haiyan Dong, Department of Pharmacy, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of China, Tel/Fax +86-29-85323508, Email batistuta28@126.comBackground: Linezolid-induced thrombocytopenia incidence varies considerably. Linezolid-related thrombocytopenia in patients has received few studies which have investigated risk factors including platelet parameters except for platelet counts. The study aims to analyze the effect of platelet parameters, including mean platelet volume and platelet large cell ratio, on linezolid-related thrombocytopenia in patients.Methods: The effect of platelet parameters on linezolid-related thrombocytopenia was identified by univariate and multivariate logistic regressions. A Kaplan–Meier survival analysis was carried out to compare the survival of patients who developed linezolid-related thrombocytopenia with patients who did not.Results: Thrombocytopenia occurred at a rate of 41.5% (66/159) after linezolid therapy in hospitalized patients. Platelet parameters, including the difference in mean platelet volume (MPV/fL=0.08 (− 1.2– 0.9)vs-0.5 (− 1.5– 0.3), (OR, 0.459; P = 0.001), the difference in platelet large cell ratio (PLCR/fL=0.9 (− 5.1– 6.2)vs-3.8 (− 8.6– 2.4), (OR, 1.156; P = 0.001), baseline platelet counts (OR, 0.995; P = 0.006) and duration of linezolid therapy≥ 10d (OR, 1.346; P = 0.007), were significantly associated with linezolid-related thrombocytopenia in hospitalized patients. In addition, other risk factors which also are associated with linezolid-related thrombocytopenia include baseline red blood cells, co-medication with parecoxib and co-medication with caspofungin. Accumulated in-hospital mortality of patients with thrombocytopenia was significantly higher than that of patients without thrombocytopenia during linezolid treatment (19.7% vs 8.6%, P = 0.003).Conclusion: The difference in mean platelet volume, the difference in large platelet ratio, baseline platelet counts and duration of linezolid therapy≥ 10d significantly affected the development of linezolid-related thrombocytopenia in hospitalized patients.Keywords: linezolid, platelet parameters, thrombocytopenia, risk factorshttps://www.dovepress.com/effect-of-platelet-parameters-on-linezolid-related-thrombocytopenia-in-peer-reviewed-fulltext-article-IDRlinezolidplatelet parametersthrombocytopeniarisk factors |
| spellingShingle | Zhang L Yan Y Liao R Dong H Effect of Platelet Parameters on Linezolid-Related Thrombocytopenia in Hospitalized Patients Infection and Drug Resistance linezolid platelet parameters thrombocytopenia risk factors |
| title | Effect of Platelet Parameters on Linezolid-Related Thrombocytopenia in Hospitalized Patients |
| title_full | Effect of Platelet Parameters on Linezolid-Related Thrombocytopenia in Hospitalized Patients |
| title_fullStr | Effect of Platelet Parameters on Linezolid-Related Thrombocytopenia in Hospitalized Patients |
| title_full_unstemmed | Effect of Platelet Parameters on Linezolid-Related Thrombocytopenia in Hospitalized Patients |
| title_short | Effect of Platelet Parameters on Linezolid-Related Thrombocytopenia in Hospitalized Patients |
| title_sort | effect of platelet parameters on linezolid related thrombocytopenia in hospitalized patients |
| topic | linezolid platelet parameters thrombocytopenia risk factors |
| url | https://www.dovepress.com/effect-of-platelet-parameters-on-linezolid-related-thrombocytopenia-in-peer-reviewed-fulltext-article-IDR |
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