Antibody and immune memory persistence post infant hepatitis B vaccination
Shuaibu A Hudu,1,2 Yasmin A Malik,3 Mohd Taib Niazlin,1 Nabil S Harmal,1,4 Ariza Adnan,5 Ahmed S Alshrari,1 Zamberi Sekawi1 1Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia; 2Department of Pathology...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2013-09-01
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| Series: | Patient Preference and Adherence |
| Online Access: | http://www.dovepress.com/antibody-and-immune-memory-persistence-post-infant-hepatitis-b-vaccina-a14505 |
| _version_ | 1819213069883015168 |
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| author | Hudu SA Malik YA Niazlin MT Harmal NS Adnan A Alshrari AS Sekawi Z |
| author_facet | Hudu SA Malik YA Niazlin MT Harmal NS Adnan A Alshrari AS Sekawi Z |
| author_sort | Hudu SA |
| collection | DOAJ |
| description | Shuaibu A Hudu,1,2 Yasmin A Malik,3 Mohd Taib Niazlin,1 Nabil S Harmal,1,4 Ariza Adnan,5 Ahmed S Alshrari,1 Zamberi Sekawi1 1Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia; 2Department of Pathology and Medical Microbiology, College of Health Sciences, Usmanu Danfodiyo University Sokoto, Sokoto State, Nigeria; 3Department of Clinical Science, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Selangor, Malaysia; 4Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen; 5Cluster of Laboratory Medical Sciences, Faculty of Medicine Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia Objectives: This study aimed to evaluate the level of hepatitis B immunity among undergraduate students 23 years after commencement of the nationwide hepatitis B childhood immunization program in Malaysia. Methods: A total of 402 serum samples obtained from volunteer undergraduate students were screened for the presence of hepatitis B surface antibodies using qualitative ELISA. Results: Results showed that 62.7% of volunteers had protective anti-hepatitis B surface antigens (≥10 IU/L), of whom 67.9% received three doses of the vaccine. The estimated post-vaccination immunity was found to be at least 20 years, indicating persistent immunity against hepatitis B and a significant association (P < 0.05) with duration of vaccination. Anamnestic response 1 month post-hepatitis B booster was 94.0% and highly significant (P < 0.01). Isolated anti-hepatitis B core antigen (anti-HBc) prevalence was found to be 5.0%, all having had a positive anamnestic response. Conclusion: Immunity after primary vaccination with hepatitis B recombinant vaccine persists for at least 20 years post-vaccination, with significant association with the number of vaccinations. Furthermore, the presence of anamnestic response to booster vaccine indicates long-lasting immunity despite decreasing antibody levels; therefore, the need for hepatitis B vaccine boosters may not be of significant benefit after complete infant vaccination. Keywords: hepatitis B vaccination, persistent immunity, anamnestic response, booster vaccination |
| first_indexed | 2024-12-23T06:53:00Z |
| format | Article |
| id | doaj.art-8daf8fc8c9554c049377433f9807b861 |
| institution | Directory Open Access Journal |
| issn | 1177-889X |
| language | English |
| last_indexed | 2024-12-23T06:53:00Z |
| publishDate | 2013-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Preference and Adherence |
| spelling | doaj.art-8daf8fc8c9554c049377433f9807b8612022-12-21T17:56:23ZengDove Medical PressPatient Preference and Adherence1177-889X2013-09-012013default981986Antibody and immune memory persistence post infant hepatitis B vaccinationHudu SAMalik YANiazlin MTHarmal NSAdnan AAlshrari ASSekawi ZShuaibu A Hudu,1,2 Yasmin A Malik,3 Mohd Taib Niazlin,1 Nabil S Harmal,1,4 Ariza Adnan,5 Ahmed S Alshrari,1 Zamberi Sekawi1 1Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia; 2Department of Pathology and Medical Microbiology, College of Health Sciences, Usmanu Danfodiyo University Sokoto, Sokoto State, Nigeria; 3Department of Clinical Science, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Selangor, Malaysia; 4Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen; 5Cluster of Laboratory Medical Sciences, Faculty of Medicine Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia Objectives: This study aimed to evaluate the level of hepatitis B immunity among undergraduate students 23 years after commencement of the nationwide hepatitis B childhood immunization program in Malaysia. Methods: A total of 402 serum samples obtained from volunteer undergraduate students were screened for the presence of hepatitis B surface antibodies using qualitative ELISA. Results: Results showed that 62.7% of volunteers had protective anti-hepatitis B surface antigens (≥10 IU/L), of whom 67.9% received three doses of the vaccine. The estimated post-vaccination immunity was found to be at least 20 years, indicating persistent immunity against hepatitis B and a significant association (P < 0.05) with duration of vaccination. Anamnestic response 1 month post-hepatitis B booster was 94.0% and highly significant (P < 0.01). Isolated anti-hepatitis B core antigen (anti-HBc) prevalence was found to be 5.0%, all having had a positive anamnestic response. Conclusion: Immunity after primary vaccination with hepatitis B recombinant vaccine persists for at least 20 years post-vaccination, with significant association with the number of vaccinations. Furthermore, the presence of anamnestic response to booster vaccine indicates long-lasting immunity despite decreasing antibody levels; therefore, the need for hepatitis B vaccine boosters may not be of significant benefit after complete infant vaccination. Keywords: hepatitis B vaccination, persistent immunity, anamnestic response, booster vaccinationhttp://www.dovepress.com/antibody-and-immune-memory-persistence-post-infant-hepatitis-b-vaccina-a14505 |
| spellingShingle | Hudu SA Malik YA Niazlin MT Harmal NS Adnan A Alshrari AS Sekawi Z Antibody and immune memory persistence post infant hepatitis B vaccination Patient Preference and Adherence |
| title | Antibody and immune memory persistence post infant hepatitis B vaccination |
| title_full | Antibody and immune memory persistence post infant hepatitis B vaccination |
| title_fullStr | Antibody and immune memory persistence post infant hepatitis B vaccination |
| title_full_unstemmed | Antibody and immune memory persistence post infant hepatitis B vaccination |
| title_short | Antibody and immune memory persistence post infant hepatitis B vaccination |
| title_sort | antibody and immune memory persistence post infant hepatitis b vaccination |
| url | http://www.dovepress.com/antibody-and-immune-memory-persistence-post-infant-hepatitis-b-vaccina-a14505 |
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