Inactivation of Autophagy in Keratinocytes Reduces Tumor Growth in Mouse Models of Epithelial Skin Cancer

Inactivation of Autophagy in Keratinocytes Reduces Tumor Growth in Mouse Models of Epithelial Skin Cancer

Autophagy is a ubiquitous degradation mechanism, which plays a critical role in cellular homeostasis. To test whether autophagy suppresses or supports the growth of tumors in the epidermis of the skin, we inactivated the essential autophagy gene <i>Atg7</i> specifically in the epidermal...

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Bibliographic Details
Main Authors: Caterina Barresi, Heidemarie Rossiter, Maria Buchberger, Johannes Pammer, Supawadee Sukseree, Maria Sibilia, Erwin Tschachler, Leopold Eckhart
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
autophagy
keratinocytes
carcinogenesis
tumor
squamous cell carcinoma
epidermis
Online Access:https://www.mdpi.com/2073-4409/11/22/3691

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