Metabolic signature of obesity-associated insulin resistance and type 2 diabetes
Abstract Background Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated comorbidities. The underlying metabolic pathways differentiating obese...
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| Format: | Article |
| Language: | English |
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BMC
2019-10-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12967-019-2096-8 |
| _version_ | 1819114685980475392 |
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| author | Haya Al-Sulaiti Ilhame Diboun Maha V. Agha Fatima F. S. Mohamed Stephen Atkin Alex S. Dömling Mohamed A. Elrayess Nayef A. Mazloum |
| author_facet | Haya Al-Sulaiti Ilhame Diboun Maha V. Agha Fatima F. S. Mohamed Stephen Atkin Alex S. Dömling Mohamed A. Elrayess Nayef A. Mazloum |
| author_sort | Haya Al-Sulaiti |
| collection | DOAJ |
| description | Abstract Background Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated comorbidities. The underlying metabolic pathways differentiating obese insulin sensitive (OIS) and obese insulin resistant (OIR) individuals remain unclear. Methods In this study, 107 subjects underwent untargeted metabolomics of serum samples using the Metabolon platform. Thirty-two subjects were lean controls whilst 75 subjects were obese including 20 OIS, 41 OIR, and 14 T2DM individuals. Results Our results showed that phospholipid metabolites including choline, glycerophosphoethanolamine and glycerophosphorylcholine were significantly altered from OIS when compared with OIR and T2DM individuals. Furthermore, our data confirmed changes in metabolic markers of liver disease, vascular disease and T2DM, such as 3-hydroxymyristate, dimethylarginine and 1,5-anhydroglucitol, respectively. Conclusion This pilot data has identified phospholipid metabolites as potential novel biomarkers of obesity-associated insulin sensitivity and confirmed the association of known metabolites with increased risk of obesity-associated insulin resistance, with possible diagnostic and therapeutic applications. Further studies are warranted to confirm these associations in prospective cohorts and to investigate their functionality. |
| first_indexed | 2024-12-22T04:49:14Z |
| format | Article |
| id | doaj.art-8db25a87749945d9917bfd151874fcaf |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-22T04:49:14Z |
| publishDate | 2019-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-8db25a87749945d9917bfd151874fcaf2022-12-21T18:38:32ZengBMCJournal of Translational Medicine1479-58762019-10-0117111110.1186/s12967-019-2096-8Metabolic signature of obesity-associated insulin resistance and type 2 diabetesHaya Al-Sulaiti0Ilhame Diboun1Maha V. Agha2Fatima F. S. Mohamed3Stephen Atkin4Alex S. Dömling5Mohamed A. Elrayess6Nayef A. Mazloum7Department of Drug Design, University of GroningenQatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU)Weill Cornell Medicine-QatarWeill Cornell Medicine-QatarWeill Cornell Medicine-QatarDepartment of Drug Design, University of GroningenBiomedical Research Center (BRC), Qatar UniversityWeill Cornell Medicine-QatarAbstract Background Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated comorbidities. The underlying metabolic pathways differentiating obese insulin sensitive (OIS) and obese insulin resistant (OIR) individuals remain unclear. Methods In this study, 107 subjects underwent untargeted metabolomics of serum samples using the Metabolon platform. Thirty-two subjects were lean controls whilst 75 subjects were obese including 20 OIS, 41 OIR, and 14 T2DM individuals. Results Our results showed that phospholipid metabolites including choline, glycerophosphoethanolamine and glycerophosphorylcholine were significantly altered from OIS when compared with OIR and T2DM individuals. Furthermore, our data confirmed changes in metabolic markers of liver disease, vascular disease and T2DM, such as 3-hydroxymyristate, dimethylarginine and 1,5-anhydroglucitol, respectively. Conclusion This pilot data has identified phospholipid metabolites as potential novel biomarkers of obesity-associated insulin sensitivity and confirmed the association of known metabolites with increased risk of obesity-associated insulin resistance, with possible diagnostic and therapeutic applications. Further studies are warranted to confirm these associations in prospective cohorts and to investigate their functionality.http://link.springer.com/article/10.1186/s12967-019-2096-8MetabolomicsBlood metabolitesInsulin sensitivityInsulin resistanceType 2 diabetes mellitus |
| spellingShingle | Haya Al-Sulaiti Ilhame Diboun Maha V. Agha Fatima F. S. Mohamed Stephen Atkin Alex S. Dömling Mohamed A. Elrayess Nayef A. Mazloum Metabolic signature of obesity-associated insulin resistance and type 2 diabetes Journal of Translational Medicine Metabolomics Blood metabolites Insulin sensitivity Insulin resistance Type 2 diabetes mellitus |
| title | Metabolic signature of obesity-associated insulin resistance and type 2 diabetes |
| title_full | Metabolic signature of obesity-associated insulin resistance and type 2 diabetes |
| title_fullStr | Metabolic signature of obesity-associated insulin resistance and type 2 diabetes |
| title_full_unstemmed | Metabolic signature of obesity-associated insulin resistance and type 2 diabetes |
| title_short | Metabolic signature of obesity-associated insulin resistance and type 2 diabetes |
| title_sort | metabolic signature of obesity associated insulin resistance and type 2 diabetes |
| topic | Metabolomics Blood metabolites Insulin sensitivity Insulin resistance Type 2 diabetes mellitus |
| url | http://link.springer.com/article/10.1186/s12967-019-2096-8 |
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