11.7 AORTIC CALCIUM SCORE AFFECTS NON-INVASIVELY OBTAINED ESTIMATES OF CENTRAL BLOOD PRESSURE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE
Background: We recently reported that central blood pressure (BP) obtained non-invasively in chronic kidney disease (CKD) patients significantly underestimated the central BP with decreasing eGFR in comparison with invasively measured true central BP in the aorta. This post-hoc analysis investigated...
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| Format: | Article |
| Language: | English |
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BMC
2016-11-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930468/view |
| _version_ | 1818547352270536704 |
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| author | Rasmus K. Carlsen Christian D. Peters Esben Laugesen Simon Winther Dinah S. Khatir Hans E. Boetker Morten Boettcher Per Ivarsen My Svensson Niels H. Buus |
| author_facet | Rasmus K. Carlsen Christian D. Peters Esben Laugesen Simon Winther Dinah S. Khatir Hans E. Boetker Morten Boettcher Per Ivarsen My Svensson Niels H. Buus |
| author_sort | Rasmus K. Carlsen |
| collection | DOAJ |
| description | Background: We recently reported that central blood pressure (BP) obtained non-invasively in chronic kidney disease (CKD) patients significantly underestimated the central BP with decreasing eGFR in comparison with invasively measured true central BP in the aorta. This post-hoc analysis investigated whether the presence of aortic calcification affected non-invasive estimates of central BP.
Methods: CKD stage 4–5 patients undergoing coronary angiography were included. Invasive aortic BP was measured through angiography catheters. Non-invasive central BP was obtained with the SphygmoCor device. Calcium score (CS) in the aorta was quantified using CT.
Results: Twenty-four patients were enrolled (meanSD): 63% males, age 53±11 years, and eGFR 95 ml/min/1.73 m2. Invasive aortic SBP was 152±23 mmHg. Estimated central SBP was 133±20 mmHg. Ten patients had a CS=0 in both ascending and descending aorta, 2 patients had ascending aortic CS>0 while 8 patients had descending aortic CS>0 and 4 patients had both ascending and descending aortic CS>0. In patients with CS>0 in the descending aorta, central SBP was underestimated by 4(117) mmHg (P=0.02) compared to patients with CS=0. No significant difference was found between patients with and without calcium in the ascending aorta (P=0.13). In patients with CS>0 in both descending and ascending aorta central SBP was underestimated by 14(326) mmHg (P=0.02) compared to patients with CS=0 in both segments.
Conclusion: In advanced CKD, aortic calcification significantly affected the difference between estimated and invasively measured central BP. This may question the usefulness of non-invasive estimates of central BP in high-risk patients with severe aortic calcification. |
| first_indexed | 2024-12-12T08:05:37Z |
| format | Article |
| id | doaj.art-8db3b27f650c48489eeb4fbf7df911e2 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-12-12T08:05:37Z |
| publishDate | 2016-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-8db3b27f650c48489eeb4fbf7df911e22022-12-22T00:31:59ZengBMCArtery Research1876-44012016-11-011610.1016/j.artres.2016.10.09511.7 AORTIC CALCIUM SCORE AFFECTS NON-INVASIVELY OBTAINED ESTIMATES OF CENTRAL BLOOD PRESSURE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASERasmus K. CarlsenChristian D. PetersEsben LaugesenSimon WintherDinah S. KhatirHans E. BoetkerMorten BoettcherPer IvarsenMy SvenssonNiels H. BuusBackground: We recently reported that central blood pressure (BP) obtained non-invasively in chronic kidney disease (CKD) patients significantly underestimated the central BP with decreasing eGFR in comparison with invasively measured true central BP in the aorta. This post-hoc analysis investigated whether the presence of aortic calcification affected non-invasive estimates of central BP. Methods: CKD stage 4–5 patients undergoing coronary angiography were included. Invasive aortic BP was measured through angiography catheters. Non-invasive central BP was obtained with the SphygmoCor device. Calcium score (CS) in the aorta was quantified using CT. Results: Twenty-four patients were enrolled (meanSD): 63% males, age 53±11 years, and eGFR 95 ml/min/1.73 m2. Invasive aortic SBP was 152±23 mmHg. Estimated central SBP was 133±20 mmHg. Ten patients had a CS=0 in both ascending and descending aorta, 2 patients had ascending aortic CS>0 while 8 patients had descending aortic CS>0 and 4 patients had both ascending and descending aortic CS>0. In patients with CS>0 in the descending aorta, central SBP was underestimated by 4(117) mmHg (P=0.02) compared to patients with CS=0. No significant difference was found between patients with and without calcium in the ascending aorta (P=0.13). In patients with CS>0 in both descending and ascending aorta central SBP was underestimated by 14(326) mmHg (P=0.02) compared to patients with CS=0 in both segments. Conclusion: In advanced CKD, aortic calcification significantly affected the difference between estimated and invasively measured central BP. This may question the usefulness of non-invasive estimates of central BP in high-risk patients with severe aortic calcification.https://www.atlantis-press.com/article/125930468/view |
| spellingShingle | Rasmus K. Carlsen Christian D. Peters Esben Laugesen Simon Winther Dinah S. Khatir Hans E. Boetker Morten Boettcher Per Ivarsen My Svensson Niels H. Buus 11.7 AORTIC CALCIUM SCORE AFFECTS NON-INVASIVELY OBTAINED ESTIMATES OF CENTRAL BLOOD PRESSURE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE Artery Research |
| title | 11.7 AORTIC CALCIUM SCORE AFFECTS NON-INVASIVELY OBTAINED ESTIMATES OF CENTRAL BLOOD PRESSURE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE |
| title_full | 11.7 AORTIC CALCIUM SCORE AFFECTS NON-INVASIVELY OBTAINED ESTIMATES OF CENTRAL BLOOD PRESSURE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE |
| title_fullStr | 11.7 AORTIC CALCIUM SCORE AFFECTS NON-INVASIVELY OBTAINED ESTIMATES OF CENTRAL BLOOD PRESSURE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE |
| title_full_unstemmed | 11.7 AORTIC CALCIUM SCORE AFFECTS NON-INVASIVELY OBTAINED ESTIMATES OF CENTRAL BLOOD PRESSURE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE |
| title_short | 11.7 AORTIC CALCIUM SCORE AFFECTS NON-INVASIVELY OBTAINED ESTIMATES OF CENTRAL BLOOD PRESSURE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE |
| title_sort | 11 7 aortic calcium score affects non invasively obtained estimates of central blood pressure in patients with advanced chronic kidney disease |
| url | https://www.atlantis-press.com/article/125930468/view |
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