Computer-aided peptide-based drug design for inositol-requiring enzyme 1

Computer-aided peptide-based drug design for inositol-requiring enzyme 1

Inositol-requiring enzyme 1 (IRE1), an endoplasmic reticulum (ER) transmembrane protein with both kinase and endoribonuclease activities, plays an essential role during ER stress and its subsequent unfolded protein response (UPR). Recent evidence shows IRE1 signaling contributes to tumorigenesis an...

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Bibliographic Details
Main Authors: Alireza Ghanbari, Amir Norouzy, Negar Balmeh, Najaf Allahyari Fard, Mohammad Amin Moosavi
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2023-10-01
Series:Basic & Clinical Cancer Research
Subjects:
Bioinformatics
cancer
drug design
inositol-requiring enzyme 1
short peptides
Online Access:https://bccr.tums.ac.ir/index.php/bccrj/article/view/495

Internet

https://bccr.tums.ac.ir/index.php/bccrj/article/view/495

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