Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs

Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs

An orally bioavailable acyl coenzyme A:cholesterol acyltransferase (ACAT) inhibitor, avasimibe (CI-1011), was used to test the hypothesis that inhibition of cholesterol esterification, in vivo, would reduce hepatic very low density (VLDL) apolipoprotein (apo) B secretion into plasma. ApoB kinetic st...

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Bibliographic Details
Main Authors: John R. Burnett, Lisa J. Wilcox, Dawn E. Telford, Sandra J. Kleinstiver, P. Hugh R. Barrett, Roger S. Newton, Murray W. Huff
Format: Article
Language:English
Published: Elsevier 1999-07-01
Series:Journal of Lipid Research
Subjects:
ACAT inhibitor
avasimibe
apolipoprotein B metabolism
kinetics
mRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520334945

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