Management of sinonasal and skull base non-mesenchymal chondrosarcoma, a narrative review
Background: Chondrosarcoma (CS) is a rare malignant cartilage forming tumor accounting for 6% of skull base neoplasia. CS often presents insidiously, it almost never metastasizes but it has an indolent progressive course leading to significant morbidity and mortality due to invasion of the clivus an...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Stichting NASE
2018-08-01
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| Series: | Rhinology Online |
| Subjects: | |
| Online Access: | https://www.rhinologyonline.org/Rhinology_online_issues/manuscript_26.pdf |
| _version_ | 1818727845152686080 |
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| author | Mark S. Ferguson Valerie J. Lund David Howard Henrik Hellquist Guy Petruzzelli Carl Snyderman Primož Strojan Carlos Suarez Alessandra Rinaldo Fernando Lopez Alfio Ferlito |
| author_facet | Mark S. Ferguson Valerie J. Lund David Howard Henrik Hellquist Guy Petruzzelli Carl Snyderman Primož Strojan Carlos Suarez Alessandra Rinaldo Fernando Lopez Alfio Ferlito |
| author_sort | Mark S. Ferguson |
| collection | DOAJ |
| description | Background: Chondrosarcoma (CS) is a rare malignant cartilage forming tumor accounting for 6% of skull base neoplasia. CS often presents insidiously, it almost never metastasizes but it has an indolent progressive course leading to significant morbidity and mortality due to invasion of the clivus and central skull base. This study performed a review of the management of CS.
Methods: A review of English language literature identified 20 studies to which we added a case series from one institution.
Results: Total number of patients included was 734. Main treatment modality was surgery performed in combination with post-operative radiotherapy (64.0%) or surgery alone (30.4%). The majority of patients recorded were either alive and well (68.1%) or alive with disease (16.6%) with 15.3% dead of disease.
Conclusions: On present evidence, surgery should form the primary treatment with a goal of complete resection. Inaccessible recurrences or high grade tumors are candidates for proton beam radiotherapy following surgery. |
| first_indexed | 2024-12-17T22:20:34Z |
| format | Article |
| id | doaj.art-8db5c9ed2dd0409aa159e02e3d2104c9 |
| institution | Directory Open Access Journal |
| issn | 2589-5613 |
| language | English |
| last_indexed | 2024-12-17T22:20:34Z |
| publishDate | 2018-08-01 |
| publisher | Stichting NASE |
| record_format | Article |
| series | Rhinology Online |
| spelling | doaj.art-8db5c9ed2dd0409aa159e02e3d2104c92022-12-21T21:30:29ZengStichting NASERhinology Online2589-56132018-08-0119410310.4193/RHINOL/18.025Management of sinonasal and skull base non-mesenchymal chondrosarcoma, a narrative reviewMark S. Ferguson0Valerie J. Lund1David Howard2Henrik Hellquist3Guy Petruzzelli4Carl Snyderman5Primož Strojan6Carlos Suarez7Alessandra Rinaldo8Fernando Lopez9Alfio Ferlito10Professorial Unit, The Royal National Throat, Nose and Ear Hospital, London, UKProfessorial Unit, The Royal National Throat, Nose and Ear Hospital, London, UK; Rhinology Research Unit, University College London, UKDepartment of ENT and Head and Neck Surgery, Imperial College London, UKDepartment of Biomedical Sciences and Medicine, University of Algarve, Faro, PortugalCurtis & Elizabeth Anderson Cancer Institute, Memorial University Medical Center Savannah GA, USACenter for Cranial Base Surgery, Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USADepartment of Radiation Oncology, Institute of Oncology, Ljubljana, SloveniaInstituto de Investigación Sanitaria del Principado de Asturias and CIBERONC, ISCIII, Oviedo, Spain Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Oviedo, SpainUniversity of Udine School of Medicine, Udine, ItalyDepartment of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias and CIBERONC, ISCIII, Oviedo, SpainCoordinator of the International Head and Neck Scientific GroupBackground: Chondrosarcoma (CS) is a rare malignant cartilage forming tumor accounting for 6% of skull base neoplasia. CS often presents insidiously, it almost never metastasizes but it has an indolent progressive course leading to significant morbidity and mortality due to invasion of the clivus and central skull base. This study performed a review of the management of CS. Methods: A review of English language literature identified 20 studies to which we added a case series from one institution. Results: Total number of patients included was 734. Main treatment modality was surgery performed in combination with post-operative radiotherapy (64.0%) or surgery alone (30.4%). The majority of patients recorded were either alive and well (68.1%) or alive with disease (16.6%) with 15.3% dead of disease. Conclusions: On present evidence, surgery should form the primary treatment with a goal of complete resection. Inaccessible recurrences or high grade tumors are candidates for proton beam radiotherapy following surgery.https://www.rhinologyonline.org/Rhinology_online_issues/manuscript_26.pdfchondrosarcomaskull basesinonasalendoscopicproton beam |
| spellingShingle | Mark S. Ferguson Valerie J. Lund David Howard Henrik Hellquist Guy Petruzzelli Carl Snyderman Primož Strojan Carlos Suarez Alessandra Rinaldo Fernando Lopez Alfio Ferlito Management of sinonasal and skull base non-mesenchymal chondrosarcoma, a narrative review Rhinology Online chondrosarcoma skull base sinonasal endoscopic proton beam |
| title | Management of sinonasal and skull base non-mesenchymal chondrosarcoma, a narrative review |
| title_full | Management of sinonasal and skull base non-mesenchymal chondrosarcoma, a narrative review |
| title_fullStr | Management of sinonasal and skull base non-mesenchymal chondrosarcoma, a narrative review |
| title_full_unstemmed | Management of sinonasal and skull base non-mesenchymal chondrosarcoma, a narrative review |
| title_short | Management of sinonasal and skull base non-mesenchymal chondrosarcoma, a narrative review |
| title_sort | management of sinonasal and skull base non mesenchymal chondrosarcoma a narrative review |
| topic | chondrosarcoma skull base sinonasal endoscopic proton beam |
| url | https://www.rhinologyonline.org/Rhinology_online_issues/manuscript_26.pdf |
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