Blocking of the Ubiquitin-Proteasome System Prevents Inflammation-Induced Bone Loss by Accelerating M-CSF Receptor c-Fms Degradation in Osteoclast Differentiation

Blocking of the Ubiquitin-Proteasome System Prevents Inflammation-Induced Bone Loss by Accelerating M-CSF Receptor c-Fms Degradation in Osteoclast Differentiation

Anti-osteoporotic activity of a blocker of the ubiquitin-proteasome system, bortezomib, has known to be achieved by directly opposed action in increased bone formation by osteoblasts and in decreased bone destruction by osteoclasts. However, the mechanisms underlying the proteasome blocker inhibitio...

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Bibliographic Details
Main Authors: Kyunghee Lee, Mi Yeong Kim, Heejin Ahn, Han-Sung Kim, Hong-In Shin, Daewon Jeong
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:International Journal of Molecular Sciences
Subjects:
proteasome inhibitors
c-Fms
osteoclast
bone resorption
Online Access:https://www.mdpi.com/1422-0067/18/10/2054

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