Huperzine A provides robust and sustained protection against induced seizures in Scn1a mutant mice

Huperzine A provides robust and sustained protection against induced seizures in Scn1a mutant mice

De novo loss-of-function mutations in the voltage-gated sodium channel (VGSC) SCN1A (encoding Nav1.1) are the main cause of Dravet syndrome (DS), a catastrophic early-life encephalopathy associated with prolonged and recurrent early-life febrile seizures (FSs), refractory afebrile epilepsy, cognitiv...

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Bibliographic Details
Main Authors: Jennifer C. Wong, Stacey B.B. Dutton, Stephen D. Collins, Steven Schachter, Andrew Escayg
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Pharmacology
Subjects:
seizure
SCN1A
huperzine A
DRAVET syndrome
Genetic epilepsy with febrile seizures plus
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00357/full

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