Potential differences in somatosensory function during premenopause and early and late postmenopause in patients with burning mouth syndrome: An observational case–control study

Background/purpose: Burning mouth syndrome (BMS) is a chronic condition presenting as intraoral burning or dysesthesia, with a high preponderance in menopausal women. This study aimed to examine the association between somatosensory dysfunction and BMS in premenopausal, early postmenopausal, and lat...

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Main Authors: Kana Ozasa, Noboru Noma, Andrew Young, Olga A. Korczeniewska, Eli Eliav, Yoshiki Imamura
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Journal of Dental Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1991790221002014
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author Kana Ozasa
Noboru Noma
Andrew Young
Olga A. Korczeniewska
Eli Eliav
Yoshiki Imamura
author_facet Kana Ozasa
Noboru Noma
Andrew Young
Olga A. Korczeniewska
Eli Eliav
Yoshiki Imamura
author_sort Kana Ozasa
collection DOAJ
description Background/purpose: Burning mouth syndrome (BMS) is a chronic condition presenting as intraoral burning or dysesthesia, with a high preponderance in menopausal women. This study aimed to examine the association between somatosensory dysfunction and BMS in premenopausal, early postmenopausal, and late postmenopausal patients, using a standardized Quantitative Sensory Testing (QST) protocol, and to determine the predictive value of thermal or mechanical perception by QST for detecting BMS. Materials and methods: An observational case–control study was performed with 36 female participants with BMS (12 premenopausal, 10 early postmenopausal, and 14 late postmenopausal) and 42 age- and sex-matched healthy volunteers (21 premenopausal, 10 early postmenopausal, and 11 late postmenopausal). Neurophysiological tests were used to evaluate somatosensory dysfunction at the tongue. Results: Z-score in the late postmenopausal BMS group revealed a gain of function for the cold pain threshold and heat pain threshold (Z = 2.08 and 3.38, respectively). In the multiple regression analysis with the Visual Analog Scale as the dependent variable, the vibration detection threshold predicted the severity of burning mouth sensation in the premenopausal group. Conclusion: Late postmenopausal patients with BMS showed an increased response of the tongue to noxious thermal stimuli. This supports the theory that changes in sex hormones may affect trigeminal somatosensory function, particularly during the late postmenopausal stage in patients with BMS.
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spelling doaj.art-8dbd42e6ab3e40f4b0e73cb6dcadb33c2022-12-21T23:27:33ZengElsevierJournal of Dental Sciences1991-79022022-01-01171399406Potential differences in somatosensory function during premenopause and early and late postmenopause in patients with burning mouth syndrome: An observational case–control studyKana Ozasa0Noboru Noma1Andrew Young2Olga A. Korczeniewska3Eli Eliav4Yoshiki Imamura5Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Nihon University, Tokyo, JapanDepartment of Oral Diagnostic Sciences, Nihon University School of Dentistry, Nihon University, Tokyo, Japan; Corresponding author.Department of Diagnostic Sciences, Arthur Dugoni School of Dentistry, University of the Pacific, San Francisco, United StatesCenter for Orofacial Pain and Temporomandibular Disorders, Department of Diagnostic Sciences, Rutgers School of Dental Medicine, Rutgers, The State University of New Jersey, Newark, NJ, USAEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USADepartment of Oral Diagnostic Sciences, Nihon University School of Dentistry, Nihon University, Tokyo, JapanBackground/purpose: Burning mouth syndrome (BMS) is a chronic condition presenting as intraoral burning or dysesthesia, with a high preponderance in menopausal women. This study aimed to examine the association between somatosensory dysfunction and BMS in premenopausal, early postmenopausal, and late postmenopausal patients, using a standardized Quantitative Sensory Testing (QST) protocol, and to determine the predictive value of thermal or mechanical perception by QST for detecting BMS. Materials and methods: An observational case–control study was performed with 36 female participants with BMS (12 premenopausal, 10 early postmenopausal, and 14 late postmenopausal) and 42 age- and sex-matched healthy volunteers (21 premenopausal, 10 early postmenopausal, and 11 late postmenopausal). Neurophysiological tests were used to evaluate somatosensory dysfunction at the tongue. Results: Z-score in the late postmenopausal BMS group revealed a gain of function for the cold pain threshold and heat pain threshold (Z = 2.08 and 3.38, respectively). In the multiple regression analysis with the Visual Analog Scale as the dependent variable, the vibration detection threshold predicted the severity of burning mouth sensation in the premenopausal group. Conclusion: Late postmenopausal patients with BMS showed an increased response of the tongue to noxious thermal stimuli. This supports the theory that changes in sex hormones may affect trigeminal somatosensory function, particularly during the late postmenopausal stage in patients with BMS.http://www.sciencedirect.com/science/article/pii/S1991790221002014Burning mouth syndromeQuantitative sensory testingMenopauseVisual analog scale
spellingShingle Kana Ozasa
Noboru Noma
Andrew Young
Olga A. Korczeniewska
Eli Eliav
Yoshiki Imamura
Potential differences in somatosensory function during premenopause and early and late postmenopause in patients with burning mouth syndrome: An observational case–control study
Journal of Dental Sciences
Burning mouth syndrome
Quantitative sensory testing
Menopause
Visual analog scale
title Potential differences in somatosensory function during premenopause and early and late postmenopause in patients with burning mouth syndrome: An observational case–control study
title_full Potential differences in somatosensory function during premenopause and early and late postmenopause in patients with burning mouth syndrome: An observational case–control study
title_fullStr Potential differences in somatosensory function during premenopause and early and late postmenopause in patients with burning mouth syndrome: An observational case–control study
title_full_unstemmed Potential differences in somatosensory function during premenopause and early and late postmenopause in patients with burning mouth syndrome: An observational case–control study
title_short Potential differences in somatosensory function during premenopause and early and late postmenopause in patients with burning mouth syndrome: An observational case–control study
title_sort potential differences in somatosensory function during premenopause and early and late postmenopause in patients with burning mouth syndrome an observational case control study
topic Burning mouth syndrome
Quantitative sensory testing
Menopause
Visual analog scale
url http://www.sciencedirect.com/science/article/pii/S1991790221002014
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