Take a Break to Repair: A Dip in the World of Double-Strand Break Repair Mechanisms Pointing the Gaze on Archaea
All organisms have evolved many DNA repair pathways to counteract the different types of DNA damages. The detection of DNA damage leads to distinct cellular responses that bring about cell cycle arrest and the induction of DNA repair mechanisms. In particular, DNA double-strand breaks (DSBs) are ext...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/24/13296 |
| _version_ | 1797503882907090944 |
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| author | Mariarosaria De Falco Mariarita De Felice |
| author_facet | Mariarosaria De Falco Mariarita De Felice |
| author_sort | Mariarosaria De Falco |
| collection | DOAJ |
| description | All organisms have evolved many DNA repair pathways to counteract the different types of DNA damages. The detection of DNA damage leads to distinct cellular responses that bring about cell cycle arrest and the induction of DNA repair mechanisms. In particular, DNA double-strand breaks (DSBs) are extremely toxic for cell survival, that is why cells use specific mechanisms of DNA repair in order to maintain genome stability. The choice among the repair pathways is mainly linked to the cell cycle phases. Indeed, if it occurs in an inappropriate cellular context, it may cause genome rearrangements, giving rise to many types of human diseases, from developmental disorders to cancer. Here, we analyze the most recent remarks about the main pathways of DSB repair with the focus on homologous recombination. A thorough knowledge in DNA repair mechanisms is pivotal for identifying the most accurate treatments in human diseases. |
| first_indexed | 2024-03-10T03:56:44Z |
| format | Article |
| id | doaj.art-8dc0f9ef120d464f9ba6f1866f488381 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:56:44Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8dc0f9ef120d464f9ba6f1866f4883812023-11-23T08:44:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122241329610.3390/ijms222413296Take a Break to Repair: A Dip in the World of Double-Strand Break Repair Mechanisms Pointing the Gaze on ArchaeaMariarosaria De Falco0Mariarita De Felice1Institute of Biosciences and BioResources, Consiglio Nazionale delle Ricerche, 80131 Naples, ItalyInstitute of Biosciences and BioResources, Consiglio Nazionale delle Ricerche, 80131 Naples, ItalyAll organisms have evolved many DNA repair pathways to counteract the different types of DNA damages. The detection of DNA damage leads to distinct cellular responses that bring about cell cycle arrest and the induction of DNA repair mechanisms. In particular, DNA double-strand breaks (DSBs) are extremely toxic for cell survival, that is why cells use specific mechanisms of DNA repair in order to maintain genome stability. The choice among the repair pathways is mainly linked to the cell cycle phases. Indeed, if it occurs in an inappropriate cellular context, it may cause genome rearrangements, giving rise to many types of human diseases, from developmental disorders to cancer. Here, we analyze the most recent remarks about the main pathways of DSB repair with the focus on homologous recombination. A thorough knowledge in DNA repair mechanisms is pivotal for identifying the most accurate treatments in human diseases.https://www.mdpi.com/1422-0067/22/24/13296DSBDNA repairhomologous recombinationDNA end resectionarchaea |
| spellingShingle | Mariarosaria De Falco Mariarita De Felice Take a Break to Repair: A Dip in the World of Double-Strand Break Repair Mechanisms Pointing the Gaze on Archaea International Journal of Molecular Sciences DSB DNA repair homologous recombination DNA end resection archaea |
| title | Take a Break to Repair: A Dip in the World of Double-Strand Break Repair Mechanisms Pointing the Gaze on Archaea |
| title_full | Take a Break to Repair: A Dip in the World of Double-Strand Break Repair Mechanisms Pointing the Gaze on Archaea |
| title_fullStr | Take a Break to Repair: A Dip in the World of Double-Strand Break Repair Mechanisms Pointing the Gaze on Archaea |
| title_full_unstemmed | Take a Break to Repair: A Dip in the World of Double-Strand Break Repair Mechanisms Pointing the Gaze on Archaea |
| title_short | Take a Break to Repair: A Dip in the World of Double-Strand Break Repair Mechanisms Pointing the Gaze on Archaea |
| title_sort | take a break to repair a dip in the world of double strand break repair mechanisms pointing the gaze on archaea |
| topic | DSB DNA repair homologous recombination DNA end resection archaea |
| url | https://www.mdpi.com/1422-0067/22/24/13296 |
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