Improvement of Cognitive Function and Interleukin 1 Beta Serum Concentrations Following Cardiac Pacemaker Implantation in Patients with Symptomatic Bradycardia
Background and aim: Bradyarrhythmias cause a low cerebral blood flow with secondary neuronal ischemia and cognitive dysfunction. This study aims to assess the effect of cardiac pacemaker implantation (PI) on the cognitive function and inflammatory markers (TNF alpha, IL1β). Material and method: We c...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/8/770 |
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| author | Alexandru Martis Gabriel Gusetu Gabriel Cismaru Dumitru Zdrenghea Daniel-Corneliu Leucuta Dana Pop |
| author_facet | Alexandru Martis Gabriel Gusetu Gabriel Cismaru Dumitru Zdrenghea Daniel-Corneliu Leucuta Dana Pop |
| author_sort | Alexandru Martis |
| collection | DOAJ |
| description | Background and aim: Bradyarrhythmias cause a low cerebral blood flow with secondary neuronal ischemia and cognitive dysfunction. This study aims to assess the effect of cardiac pacemaker implantation (PI) on the cognitive function and inflammatory markers (TNF alpha, IL1β). Material and method: We conducted a prospective observational study on a number of 31 patients with symptomatic bradyarrhythmias. We performed the cognitive function assessment by two tests (Mini-Mental State Examination and Trail Making Test A), cardiac output assessment (echocardiographic), and determination of IL 1β and TNF alpha serum concentrations before pacemaker implantation and after an average period of 42 days from pacemaker implantation.Results: After pacemaker implantation we observed an increase in the cardiac index by 0.71 L/min/m<sup>2</sup> (<i>p</i> < 0.001) and a better scoring in cognitive performance; the mean MMSE score increased by two points (<i>p</i> < 0.001), and Trail Making Test A had an improvement of 16 s (<i>p</i> < 0.001). Regarding the inflammatory markers, a significant decrease in IL-1β with 8.6 pg/mL (<i>p</i> = 0.049) after pacemaker implantation was observed. Additionally, we found statistically significant correlations between IL1β and TNF alpha (positive correlation, <i>p</i> = 0.005), between the MMSE and cardiac index (<i>p</i> < 0.001), between the Trail Making Test and cardiac index (<i>p</i> = 0.001), and between the MMSE and Trail Making Test (<i>p</i> = 0.003). Conclusions: Our findings suggest that cardiac pacemaker implantation was associated with improved cognitive function—possibly related to an increased cardiac output and with adecreased serum IL1β concentration in subjects with symptomatic bradycardia. |
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| language | English |
| last_indexed | 2024-03-10T08:41:08Z |
| publishDate | 2021-08-01 |
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| series | Journal of Personalized Medicine |
| spelling | doaj.art-8dc1f18de0ce485f914ea154b3a3880e2023-11-22T08:19:06ZengMDPI AGJournal of Personalized Medicine2075-44262021-08-0111877010.3390/jpm11080770Improvement of Cognitive Function and Interleukin 1 Beta Serum Concentrations Following Cardiac Pacemaker Implantation in Patients with Symptomatic BradycardiaAlexandru Martis0Gabriel Gusetu1Gabriel Cismaru2Dumitru Zdrenghea3Daniel-Corneliu Leucuta4Dana Pop5Rehabilitation Hospital Cardiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaRehabilitation Hospital Cardiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaRehabilitation Hospital Cardiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaRehabilitation Hospital Cardiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaDepartment of Medical Informatics and Biostatistics, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaRehabilitation Hospital Cardiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaBackground and aim: Bradyarrhythmias cause a low cerebral blood flow with secondary neuronal ischemia and cognitive dysfunction. This study aims to assess the effect of cardiac pacemaker implantation (PI) on the cognitive function and inflammatory markers (TNF alpha, IL1β). Material and method: We conducted a prospective observational study on a number of 31 patients with symptomatic bradyarrhythmias. We performed the cognitive function assessment by two tests (Mini-Mental State Examination and Trail Making Test A), cardiac output assessment (echocardiographic), and determination of IL 1β and TNF alpha serum concentrations before pacemaker implantation and after an average period of 42 days from pacemaker implantation.Results: After pacemaker implantation we observed an increase in the cardiac index by 0.71 L/min/m<sup>2</sup> (<i>p</i> < 0.001) and a better scoring in cognitive performance; the mean MMSE score increased by two points (<i>p</i> < 0.001), and Trail Making Test A had an improvement of 16 s (<i>p</i> < 0.001). Regarding the inflammatory markers, a significant decrease in IL-1β with 8.6 pg/mL (<i>p</i> = 0.049) after pacemaker implantation was observed. Additionally, we found statistically significant correlations between IL1β and TNF alpha (positive correlation, <i>p</i> = 0.005), between the MMSE and cardiac index (<i>p</i> < 0.001), between the Trail Making Test and cardiac index (<i>p</i> = 0.001), and between the MMSE and Trail Making Test (<i>p</i> = 0.003). Conclusions: Our findings suggest that cardiac pacemaker implantation was associated with improved cognitive function—possibly related to an increased cardiac output and with adecreased serum IL1β concentration in subjects with symptomatic bradycardia.https://www.mdpi.com/2075-4426/11/8/770pacemakercognitive functionbradycardiaMMSEtrail making testInterleukin 1 beta |
| spellingShingle | Alexandru Martis Gabriel Gusetu Gabriel Cismaru Dumitru Zdrenghea Daniel-Corneliu Leucuta Dana Pop Improvement of Cognitive Function and Interleukin 1 Beta Serum Concentrations Following Cardiac Pacemaker Implantation in Patients with Symptomatic Bradycardia Journal of Personalized Medicine pacemaker cognitive function bradycardia MMSE trail making test Interleukin 1 beta |
| title | Improvement of Cognitive Function and Interleukin 1 Beta Serum Concentrations Following Cardiac Pacemaker Implantation in Patients with Symptomatic Bradycardia |
| title_full | Improvement of Cognitive Function and Interleukin 1 Beta Serum Concentrations Following Cardiac Pacemaker Implantation in Patients with Symptomatic Bradycardia |
| title_fullStr | Improvement of Cognitive Function and Interleukin 1 Beta Serum Concentrations Following Cardiac Pacemaker Implantation in Patients with Symptomatic Bradycardia |
| title_full_unstemmed | Improvement of Cognitive Function and Interleukin 1 Beta Serum Concentrations Following Cardiac Pacemaker Implantation in Patients with Symptomatic Bradycardia |
| title_short | Improvement of Cognitive Function and Interleukin 1 Beta Serum Concentrations Following Cardiac Pacemaker Implantation in Patients with Symptomatic Bradycardia |
| title_sort | improvement of cognitive function and interleukin 1 beta serum concentrations following cardiac pacemaker implantation in patients with symptomatic bradycardia |
| topic | pacemaker cognitive function bradycardia MMSE trail making test Interleukin 1 beta |
| url | https://www.mdpi.com/2075-4426/11/8/770 |
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