SARS-CoV-2 Antibody Effectiveness Is Influenced by Non-Epitope Mutation/Binding-Induced Denaturation of the Epitope 3D Architecture

SARS-CoV-2 Antibody Effectiveness Is Influenced by Non-Epitope Mutation/Binding-Induced Denaturation of the Epitope 3D Architecture

The public health threat from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to intensify with emerging variants of concern (VOC) aiming to render COVID-19 vaccines/infection-induced antibodies redundant. The SARS-CoV-2 spike protein is responsible for receptor binding and in...

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Bibliographic Details
Main Authors: Moffat M. Malisheni, Matthew Bates, Albert A. Rizvanov, Paul A. MacAry
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pathogens
Subjects:
SARS-CoV-2 VOC
spike/RBD protein
AASC repositioning
hydrogen bond
donor/acceptor atoms
Online Access:https://www.mdpi.com/2076-0817/11/12/1437

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