The association of angiotensin-converting enzyme gene insertion/deletion polymorphisms with adaptation to high altitude: A meta-analysis
Background: Fluid retention is linked to the physiology and pathophysiology of humans at high altitude (HA). The angiotensin-converting enzyme (ACE) gene plays a role in the regulation of plasma volume and vascular tone. Materials and methods: In this meta-analysis, eligible studies published before...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2016-02-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320315627410 |
| _version_ | 1797284158371790848 |
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| author | Yuxiao Wang Hongxiang Lu Yu Chen Yongjun Luo |
| author_facet | Yuxiao Wang Hongxiang Lu Yu Chen Yongjun Luo |
| author_sort | Yuxiao Wang |
| collection | DOAJ |
| description | Background: Fluid retention is linked to the physiology and pathophysiology of humans at high altitude (HA). The angiotensin-converting enzyme (ACE) gene plays a role in the regulation of plasma volume and vascular tone. Materials and methods: In this meta-analysis, eligible studies published before 1 September 2015 that focused on the association between the ACE insertion/deletion (I/D) polymorphism and HA adaption were identified by searching the PubMed, Web of Science, Embase and Medline online databases. We used a fixed-effects model and assessed the study qualities multiple times. Results: The seven selected studies included a total of 582 HA-native individuals and 497 low-altitude controls, and these subjects were analyzed for the ACE I/D gene polymorphism. A significant association was found between the ACE DD genotype and HA maladaptation. The results for genotype DD versus ID + II were as follows: Odds ratio (OR) = 0.46; 95% CI 0.31–0.70; p = 0.0002. The results for genotype ID versus DD were as follows: OR = 1.97; 95% CI 1.27–3.06; p = 0.002. Conclusions: Our findings suggested that the DD genotype of ACE is a risk factor for HA maladaptation and that the presence of fewer ACE DD allele carriers in a population indicates a greater ability of that population to adapt to HA. |
| first_indexed | 2024-03-07T17:44:00Z |
| format | Article |
| id | doaj.art-8dc33fe9efd947d5a6e4d32f16e70366 |
| institution | Directory Open Access Journal |
| issn | 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:44:00Z |
| publishDate | 2016-02-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-8dc33fe9efd947d5a6e4d32f16e703662024-03-02T15:24:50ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1752-89762016-02-011710.1177/1470320315627410The association of angiotensin-converting enzyme gene insertion/deletion polymorphisms with adaptation to high altitude: A meta-analysisYuxiao Wang0Hongxiang Lu1Yu Chen2Yongjun Luo3Key Laboratory of High-altitude Medicine, Ministry of Education, Third Military Medical University, Chongqing, ChinaKey Laboratory of High-altitude Medicine, Ministry of Education, Third Military Medical University, Chongqing, ChinaKey Laboratory of High-altitude Medicine, Ministry of Education, Third Military Medical University, Chongqing, ChinaKey Laboratory of High-altitude Medicine, Ministry of Education, Third Military Medical University, Chongqing, ChinaBackground: Fluid retention is linked to the physiology and pathophysiology of humans at high altitude (HA). The angiotensin-converting enzyme (ACE) gene plays a role in the regulation of plasma volume and vascular tone. Materials and methods: In this meta-analysis, eligible studies published before 1 September 2015 that focused on the association between the ACE insertion/deletion (I/D) polymorphism and HA adaption were identified by searching the PubMed, Web of Science, Embase and Medline online databases. We used a fixed-effects model and assessed the study qualities multiple times. Results: The seven selected studies included a total of 582 HA-native individuals and 497 low-altitude controls, and these subjects were analyzed for the ACE I/D gene polymorphism. A significant association was found between the ACE DD genotype and HA maladaptation. The results for genotype DD versus ID + II were as follows: Odds ratio (OR) = 0.46; 95% CI 0.31–0.70; p = 0.0002. The results for genotype ID versus DD were as follows: OR = 1.97; 95% CI 1.27–3.06; p = 0.002. Conclusions: Our findings suggested that the DD genotype of ACE is a risk factor for HA maladaptation and that the presence of fewer ACE DD allele carriers in a population indicates a greater ability of that population to adapt to HA.https://doi.org/10.1177/1470320315627410 |
| spellingShingle | Yuxiao Wang Hongxiang Lu Yu Chen Yongjun Luo The association of angiotensin-converting enzyme gene insertion/deletion polymorphisms with adaptation to high altitude: A meta-analysis Journal of the Renin-Angiotensin-Aldosterone System |
| title | The association of angiotensin-converting enzyme gene insertion/deletion polymorphisms with adaptation to high altitude: A meta-analysis |
| title_full | The association of angiotensin-converting enzyme gene insertion/deletion polymorphisms with adaptation to high altitude: A meta-analysis |
| title_fullStr | The association of angiotensin-converting enzyme gene insertion/deletion polymorphisms with adaptation to high altitude: A meta-analysis |
| title_full_unstemmed | The association of angiotensin-converting enzyme gene insertion/deletion polymorphisms with adaptation to high altitude: A meta-analysis |
| title_short | The association of angiotensin-converting enzyme gene insertion/deletion polymorphisms with adaptation to high altitude: A meta-analysis |
| title_sort | association of angiotensin converting enzyme gene insertion deletion polymorphisms with adaptation to high altitude a meta analysis |
| url | https://doi.org/10.1177/1470320315627410 |
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