A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention
Previous studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenetic markers in peripheral tissues. Several studies in primates...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnmol.2018.00322/full |
| _version_ | 1818412321171570688 |
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| author | Elad Lax Gal Warhaftig David Ohana Rachel Maayan Yael Delayahu Yael Delayahu Paola Roska Paola Roska Alexander M. Ponizovsky Abraham Weizman Gal Yadid Gal Yadid Moshe Szyf Moshe Szyf |
| author_facet | Elad Lax Gal Warhaftig David Ohana Rachel Maayan Yael Delayahu Yael Delayahu Paola Roska Paola Roska Alexander M. Ponizovsky Abraham Weizman Gal Yadid Gal Yadid Moshe Szyf Moshe Szyf |
| author_sort | Elad Lax |
| collection | DOAJ |
| description | Previous studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenetic markers in peripheral tissues. Several studies in primates and humans have associated differences in behavioral phenotypes with changes in DNA methylation in T cells and brain. Herein, we present a pilot study (n = 27) showing that the T cell DNA methylation profile differentiates persons with a substance use disorder from controls. Intervention with dehydroepiandrosterone (DHEA), previously shown to have a long-term therapeutic effect on human addicts herein resulted in reversal of DNA methylation changes in genes related to pathways associated with the addictive state. |
| first_indexed | 2024-12-14T10:45:27Z |
| format | Article |
| id | doaj.art-8dc4d470ebb649ca981052266b53fcc2 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-14T10:45:27Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-8dc4d470ebb649ca981052266b53fcc22022-12-21T23:05:28ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992018-09-011110.3389/fnmol.2018.00322379601A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA InterventionElad Lax0Gal Warhaftig1David Ohana2Rachel Maayan3Yael Delayahu4Yael Delayahu5Paola Roska6Paola Roska7Alexander M. Ponizovsky8Abraham Weizman9Gal Yadid10Gal Yadid11Moshe Szyf12Moshe Szyf13Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, CanadaThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, IsraelMax Wertheimer Minerva Center for Cognitive Processes and Human Performance, Technion – Israel Institute of Technology, Haifa, IsraelLaboratory of Biological Psychiatry, Felsenstein Medical Research Center, Research Unit and Geha Mental Health Center, Tel Aviv University, Tel Aviv, IsraelLaboratory of Biological Psychiatry, Felsenstein Medical Research Center, Research Unit and Geha Mental Health Center, Tel Aviv University, Tel Aviv, IsraelYehuda Abarbanel Mental Health Center, Bat Yam, IsraelDepartment for the Treatment of Substance Abuse and Mental Health Services, Israeli Ministry of Health, Jerusalem, IsraelThe Hebrew University of Jerusalem, Jerusalem, IsraelDepartment for the Treatment of Substance Abuse and Mental Health Services, Israeli Ministry of Health, Jerusalem, IsraelLaboratory of Biological Psychiatry, Felsenstein Medical Research Center, Research Unit and Geha Mental Health Center, Tel Aviv University, Tel Aviv, IsraelThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, IsraelThe Leslie and Susan Gonda (Goldschmidt) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, IsraelDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC, CanadaProgram for Epigenetics and Psychobiology, McGill University, Montreal, QC, CanadaPrevious studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenetic markers in peripheral tissues. Several studies in primates and humans have associated differences in behavioral phenotypes with changes in DNA methylation in T cells and brain. Herein, we present a pilot study (n = 27) showing that the T cell DNA methylation profile differentiates persons with a substance use disorder from controls. Intervention with dehydroepiandrosterone (DHEA), previously shown to have a long-term therapeutic effect on human addicts herein resulted in reversal of DNA methylation changes in genes related to pathways associated with the addictive state.https://www.frontiersin.org/article/10.3389/fnmol.2018.00322/fulldehydroepiandrosterone (DHEA)DNA methylationdrug abusegenome-wide analysisdrug-addiction |
| spellingShingle | Elad Lax Gal Warhaftig David Ohana Rachel Maayan Yael Delayahu Yael Delayahu Paola Roska Paola Roska Alexander M. Ponizovsky Abraham Weizman Gal Yadid Gal Yadid Moshe Szyf Moshe Szyf A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention Frontiers in Molecular Neuroscience dehydroepiandrosterone (DHEA) DNA methylation drug abuse genome-wide analysis drug-addiction |
| title | A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention |
| title_full | A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention |
| title_fullStr | A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention |
| title_full_unstemmed | A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention |
| title_short | A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention |
| title_sort | dna methylation signature of addiction in t cells and its reversal with dhea intervention |
| topic | dehydroepiandrosterone (DHEA) DNA methylation drug abuse genome-wide analysis drug-addiction |
| url | https://www.frontiersin.org/article/10.3389/fnmol.2018.00322/full |
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