Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments
Abstract Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have drastically revolutionized the field of clinical oncology, offering ease in tumor sampling, continuous monitoring by...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | Molecular Cancer |
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| Online Access: | https://doi.org/10.1186/s12943-022-01543-7 |
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| author | Saife N. Lone Sabah Nisar Tariq Masoodi Mayank Singh Arshi Rizwan Sheema Hashem Wael El-Rifai Davide Bedognetti Surinder K. Batra Mohammad Haris Ajaz A. Bhat Muzafar A. Macha |
| author_facet | Saife N. Lone Sabah Nisar Tariq Masoodi Mayank Singh Arshi Rizwan Sheema Hashem Wael El-Rifai Davide Bedognetti Surinder K. Batra Mohammad Haris Ajaz A. Bhat Muzafar A. Macha |
| author_sort | Saife N. Lone |
| collection | DOAJ |
| description | Abstract Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have drastically revolutionized the field of clinical oncology, offering ease in tumor sampling, continuous monitoring by repeated sampling, devising personalized therapeutic regimens, and screening for therapeutic resistance. Liquid biopsies consist of isolating tumor-derived entities like circulating tumor cells, circulating tumor DNA, tumor extracellular vesicles, etc., present in the body fluids of patients with cancer, followed by an analysis of genomic and proteomic data contained within them. Methods for isolation and analysis of liquid biopsies have rapidly evolved over the past few years as described in the review, thus providing greater details about tumor characteristics such as tumor progression, tumor staging, heterogeneity, gene mutations, and clonal evolution, etc. Liquid biopsies from cancer patients have opened up newer avenues in detection and continuous monitoring, treatment based on precision medicine, and screening of markers for therapeutic resistance. Though the technology of liquid biopsies is still evolving, its non-invasive nature promises to open new eras in clinical oncology. The purpose of this review is to provide an overview of the current methodologies involved in liquid biopsies and their application in isolating tumor markers for detection, prognosis, and monitoring cancer treatment outcomes. |
| first_indexed | 2024-12-13T00:03:29Z |
| format | Article |
| id | doaj.art-8dcc3e42d9b54abeb58880505f4456a7 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-13T00:03:29Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-8dcc3e42d9b54abeb58880505f4456a72022-12-22T00:06:21ZengBMCMolecular Cancer1476-45982022-03-0121112210.1186/s12943-022-01543-7Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatmentsSaife N. Lone0Sabah Nisar1Tariq Masoodi2Mayank Singh3Arshi Rizwan4Sheema Hashem5Wael El-Rifai6Davide Bedognetti7Surinder K. Batra8Mohammad Haris9Ajaz A. Bhat10Muzafar A. Macha11Department of Biotechnology, School of Life Sciences, Central University of KashmirLaboratory of Molecular and Metabolic Imaging, Cancer Research Department, Sidra MedicineLaboratory of Molecular and Metabolic Imaging, Cancer Research Department, Sidra MedicineDepartment of Medical Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences (AIIMS)Department of Nephrology, All India Institute of Medical SciencesLaboratory of Molecular and Metabolic Imaging, Cancer Research Department, Sidra MedicineDepartment of Surgery, University of Miami Miller School of MedicineCancer Research Department, Research Branch, Sidra MedicinceDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical CenterLaboratory of Molecular and Metabolic Imaging, Cancer Research Department, Sidra MedicineLaboratory of Molecular and Metabolic Imaging, Cancer Research Department, Sidra MedicineWatson-Crick Centre for Molecular Medicine, Islamic University of Science and Technology, (IUST)Abstract Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have drastically revolutionized the field of clinical oncology, offering ease in tumor sampling, continuous monitoring by repeated sampling, devising personalized therapeutic regimens, and screening for therapeutic resistance. Liquid biopsies consist of isolating tumor-derived entities like circulating tumor cells, circulating tumor DNA, tumor extracellular vesicles, etc., present in the body fluids of patients with cancer, followed by an analysis of genomic and proteomic data contained within them. Methods for isolation and analysis of liquid biopsies have rapidly evolved over the past few years as described in the review, thus providing greater details about tumor characteristics such as tumor progression, tumor staging, heterogeneity, gene mutations, and clonal evolution, etc. Liquid biopsies from cancer patients have opened up newer avenues in detection and continuous monitoring, treatment based on precision medicine, and screening of markers for therapeutic resistance. Though the technology of liquid biopsies is still evolving, its non-invasive nature promises to open new eras in clinical oncology. The purpose of this review is to provide an overview of the current methodologies involved in liquid biopsies and their application in isolating tumor markers for detection, prognosis, and monitoring cancer treatment outcomes.https://doi.org/10.1186/s12943-022-01543-7Liquid biopsyCancerCirculating tumor cellsCirculating tumor DNATumor extracellular vesiclesNon-invasive tumor detection |
| spellingShingle | Saife N. Lone Sabah Nisar Tariq Masoodi Mayank Singh Arshi Rizwan Sheema Hashem Wael El-Rifai Davide Bedognetti Surinder K. Batra Mohammad Haris Ajaz A. Bhat Muzafar A. Macha Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments Molecular Cancer Liquid biopsy Cancer Circulating tumor cells Circulating tumor DNA Tumor extracellular vesicles Non-invasive tumor detection |
| title | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments |
| title_full | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments |
| title_fullStr | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments |
| title_full_unstemmed | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments |
| title_short | Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments |
| title_sort | liquid biopsy a step closer to transform diagnosis prognosis and future of cancer treatments |
| topic | Liquid biopsy Cancer Circulating tumor cells Circulating tumor DNA Tumor extracellular vesicles Non-invasive tumor detection |
| url | https://doi.org/10.1186/s12943-022-01543-7 |
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