Muscle‐specific sirtuin1 gain‐of‐function ameliorates skeletal muscle atrophy in a pre‐clinical mouse model of cerebral ischemic stroke

Muscle‐specific sirtuin1 gain‐of‐function ameliorates skeletal muscle atrophy in a pre‐clinical mouse model of cerebral ischemic stroke

Abstract Stroke causes severe long‐term disability in patients due to the induction of skeletal muscle atrophy and weakness, but the molecular mechanisms remain elusive. Using a preclinical mouse model of cerebral ischemic stroke, we show that stroke robustly induced atrophy and significantly decrea...

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Bibliographic Details
Main Authors: Kiril Tuntevski, Ameena Hajira, Austin Nichols, Stephen E. Alway, Junaith S. Mohamed
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:FASEB BioAdvances
Subjects:
cerebral ischemic stroke
muscle atrophy
PARP‐1
SirT1
ZNF216
Online Access:https://doi.org/10.1096/fba.2020-00017

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