Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive decline [version 2; peer review: 2 approved]
Introduction: Cognitive decline, correlating with hippocampal atrophy, characterizes several neurodegenerative disorders having a background of low-level chronic inflammation and oxidative stress. Methods: In this cross-sectional study, we examined how cognitive decline and hippocampal subfields vol...
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| Format: | Article |
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F1000 Research Ltd
2022-03-01
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| Online Access: | https://f1000research.com/articles/11-114/v2 |
| _version_ | 1811246701728497664 |
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| author | Bogdan Ovidiu Popescu Maria Dobre Luiza Spiru Catalina Tudose Ioana Cracana Catalina Anca Cucos Gabriela Niculescu Gina Manda Elena Milanesi |
| author_facet | Bogdan Ovidiu Popescu Maria Dobre Luiza Spiru Catalina Tudose Ioana Cracana Catalina Anca Cucos Gabriela Niculescu Gina Manda Elena Milanesi |
| author_sort | Bogdan Ovidiu Popescu |
| collection | DOAJ |
| description | Introduction: Cognitive decline, correlating with hippocampal atrophy, characterizes several neurodegenerative disorders having a background of low-level chronic inflammation and oxidative stress. Methods: In this cross-sectional study, we examined how cognitive decline and hippocampal subfields volume are associated with the expression of redox and inflammatory genes in peripheral blood. We analyzed 34 individuals with different cognitive scores according to Mini-Mental State Examination, corrected by age and education (adjMMSE). We identified a group presenting cognitive decline (CD) with adjMMSE<27 (n=14) and a normal cognition (NC) group with adjMMSE≥27 (n=20). A multiparametric approach, comprising structural magnetic resonance imaging measurement of different hippocampal segments and blood mRNA expression of redox and inflammatory genes was applied. Results: Our findings indicate that hippocampal segment volumes correlate positively with adjMMSE and negatively with the blood transcript levels of 19 genes, mostly redox genes correlating especially with the left subiculum and presubiculum. A strong negative correlation between hippocampal subfields atrophy and Sulfiredoxin-1 (SRXN1) redox gene was emphasized. Conclusions: Concluding, these results suggest that SRXN1 might be a valuable candidate blood biomarker for non-invasively monitoring the evolution of hippocampal atrophy in CD patients. |
| first_indexed | 2024-04-12T14:57:13Z |
| format | Article |
| id | doaj.art-8dd01394953d4705b8a5c68d5d3cbe40 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-12T14:57:13Z |
| publishDate | 2022-03-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-8dd01394953d4705b8a5c68d5d3cbe402022-12-22T03:28:11ZengF1000 Research LtdF1000Research2046-14022022-03-0111122375Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive decline [version 2; peer review: 2 approved]Bogdan Ovidiu Popescu0Maria Dobre1Luiza Spiru2Catalina Tudose3Ioana Cracana4Catalina Anca Cucos5Gabriela Niculescu6Gina Manda7https://orcid.org/0000-0002-9706-1883Elena Milanesi8https://orcid.org/0000-0003-2753-3395Victor Babes National Institute of Pathology, Bucharest, 050096, RomaniaVictor Babes National Institute of Pathology, Bucharest, 050096, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaMedinst Diagnostic Romano-German SRL, Bucharest, RomaniaVictor Babes National Institute of Pathology, Bucharest, 050096, RomaniaFaculty of Medical Engineering, University Politehnica of Bucharest, Bucharest, RomaniaVictor Babes National Institute of Pathology, Bucharest, 050096, RomaniaVictor Babes National Institute of Pathology, Bucharest, 050096, RomaniaIntroduction: Cognitive decline, correlating with hippocampal atrophy, characterizes several neurodegenerative disorders having a background of low-level chronic inflammation and oxidative stress. Methods: In this cross-sectional study, we examined how cognitive decline and hippocampal subfields volume are associated with the expression of redox and inflammatory genes in peripheral blood. We analyzed 34 individuals with different cognitive scores according to Mini-Mental State Examination, corrected by age and education (adjMMSE). We identified a group presenting cognitive decline (CD) with adjMMSE<27 (n=14) and a normal cognition (NC) group with adjMMSE≥27 (n=20). A multiparametric approach, comprising structural magnetic resonance imaging measurement of different hippocampal segments and blood mRNA expression of redox and inflammatory genes was applied. Results: Our findings indicate that hippocampal segment volumes correlate positively with adjMMSE and negatively with the blood transcript levels of 19 genes, mostly redox genes correlating especially with the left subiculum and presubiculum. A strong negative correlation between hippocampal subfields atrophy and Sulfiredoxin-1 (SRXN1) redox gene was emphasized. Conclusions: Concluding, these results suggest that SRXN1 might be a valuable candidate blood biomarker for non-invasively monitoring the evolution of hippocampal atrophy in CD patients.https://f1000research.com/articles/11-114/v2SRXN1 MRI blood Cognitive declineeng |
| spellingShingle | Bogdan Ovidiu Popescu Maria Dobre Luiza Spiru Catalina Tudose Ioana Cracana Catalina Anca Cucos Gabriela Niculescu Gina Manda Elena Milanesi Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive decline [version 2; peer review: 2 approved] F1000Research SRXN1 MRI blood Cognitive decline eng |
| title | Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive decline [version 2; peer review: 2 approved] |
| title_full | Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive decline [version 2; peer review: 2 approved] |
| title_fullStr | Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive decline [version 2; peer review: 2 approved] |
| title_full_unstemmed | Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive decline [version 2; peer review: 2 approved] |
| title_short | Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive decline [version 2; peer review: 2 approved] |
| title_sort | sulfiredoxin 1 blood mrna expression levels negatively correlate with hippocampal atrophy and cognitive decline version 2 peer review 2 approved |
| topic | SRXN1 MRI blood Cognitive decline eng |
| url | https://f1000research.com/articles/11-114/v2 |
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