Polymorphisms of the apolipoprotein E gene affect response to atorvastatin therapy in acute ischemic stroke
BackgroundPolymorphisms of the apolipoprotein E (APOE) gene are related to the efficacy of statin therapy. The biological functions of the APOE subtypes determine the metabolism of blood plasma lipids and the progression of atherosclerosis. This study aimed to explore the impact of APOE gene polymor...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1024014/full |
| _version_ | 1828135178666508288 |
|---|---|
| author | QianQian Bi XiaoYu Zhou YanQin Lu Wang Fu YongPeng Wang Feng Wang Jue Wang |
| author_facet | QianQian Bi XiaoYu Zhou YanQin Lu Wang Fu YongPeng Wang Feng Wang Jue Wang |
| author_sort | QianQian Bi |
| collection | DOAJ |
| description | BackgroundPolymorphisms of the apolipoprotein E (APOE) gene are related to the efficacy of statin therapy. The biological functions of the APOE subtypes determine the metabolism of blood plasma lipids and the progression of atherosclerosis. This study aimed to explore the impact of APOE gene polymorphisms on the effect of atorvastatin on lipid regulation and plaque stabilization.MethodsThe study was a prospective cohort study that consecutively included patients with acute ischemic stroke (AIS) in the Department of Neurology, Shanghai Tenth People’s Hospital, from December 2018 to December 2019. The patients were divided into E2, E3, and E4 groups according to their APOE genotype. Atorvastatin (20 mg) was administrated to all patients. Changes in blood lipid levels over 3 months and plaque size and stability over 12 months were analyzed.ResultsWe enrolled 253 consecutive patients with AIS, of whom, 136 had carotid atherosclerotic plaques. Two patients with genotype E2/E4 were excluded. There were 30 patients in the E2 group (12.0%), 191 patients in the E3 group (76.0%), and 30 patients in the E4 group (12.0%). The lowest percentage reduction in low-density lipoprotein cholesterol (LDL-C) was observed in the E4 group (41.2%), while the highest percentage reduction was observed in the E2 group (17.6%). The plaques in the E2 group showed slower progression, while those in the E4 group showed more rapid progression.ConclusionAPOE gene polymorphisms affect the biological functions of atorvastatin. Compared to the ε3 or ε4 allele, the ε2 allele exerted a greater lipid-lowering effect on LDL-C levels, enhanced the ability of atorvastatin to stabilize carotid artery plaques, and slowed carotid artery plaque progression. |
| first_indexed | 2024-04-11T17:44:32Z |
| format | Article |
| id | doaj.art-8dd23eda1bf7446ca359c3e9f1a061b4 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T17:44:32Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-8dd23eda1bf7446ca359c3e9f1a061b42022-12-22T04:11:25ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-11-01910.3389/fcvm.2022.10240141024014Polymorphisms of the apolipoprotein E gene affect response to atorvastatin therapy in acute ischemic strokeQianQian Bi0XiaoYu Zhou1YanQin Lu2Wang Fu3YongPeng Wang4Feng Wang5Jue Wang6Department of Neurology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Neurology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Infectious Diseases, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Neurology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Neurology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Neurology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Neurology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaBackgroundPolymorphisms of the apolipoprotein E (APOE) gene are related to the efficacy of statin therapy. The biological functions of the APOE subtypes determine the metabolism of blood plasma lipids and the progression of atherosclerosis. This study aimed to explore the impact of APOE gene polymorphisms on the effect of atorvastatin on lipid regulation and plaque stabilization.MethodsThe study was a prospective cohort study that consecutively included patients with acute ischemic stroke (AIS) in the Department of Neurology, Shanghai Tenth People’s Hospital, from December 2018 to December 2019. The patients were divided into E2, E3, and E4 groups according to their APOE genotype. Atorvastatin (20 mg) was administrated to all patients. Changes in blood lipid levels over 3 months and plaque size and stability over 12 months were analyzed.ResultsWe enrolled 253 consecutive patients with AIS, of whom, 136 had carotid atherosclerotic plaques. Two patients with genotype E2/E4 were excluded. There were 30 patients in the E2 group (12.0%), 191 patients in the E3 group (76.0%), and 30 patients in the E4 group (12.0%). The lowest percentage reduction in low-density lipoprotein cholesterol (LDL-C) was observed in the E4 group (41.2%), while the highest percentage reduction was observed in the E2 group (17.6%). The plaques in the E2 group showed slower progression, while those in the E4 group showed more rapid progression.ConclusionAPOE gene polymorphisms affect the biological functions of atorvastatin. Compared to the ε3 or ε4 allele, the ε2 allele exerted a greater lipid-lowering effect on LDL-C levels, enhanced the ability of atorvastatin to stabilize carotid artery plaques, and slowed carotid artery plaque progression.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1024014/fullapolipoprotein Epolymorphismlipid-loweringatherosclerosiscarotid artery plaques |
| spellingShingle | QianQian Bi XiaoYu Zhou YanQin Lu Wang Fu YongPeng Wang Feng Wang Jue Wang Polymorphisms of the apolipoprotein E gene affect response to atorvastatin therapy in acute ischemic stroke Frontiers in Cardiovascular Medicine apolipoprotein E polymorphism lipid-lowering atherosclerosis carotid artery plaques |
| title | Polymorphisms of the apolipoprotein E gene affect response to atorvastatin therapy in acute ischemic stroke |
| title_full | Polymorphisms of the apolipoprotein E gene affect response to atorvastatin therapy in acute ischemic stroke |
| title_fullStr | Polymorphisms of the apolipoprotein E gene affect response to atorvastatin therapy in acute ischemic stroke |
| title_full_unstemmed | Polymorphisms of the apolipoprotein E gene affect response to atorvastatin therapy in acute ischemic stroke |
| title_short | Polymorphisms of the apolipoprotein E gene affect response to atorvastatin therapy in acute ischemic stroke |
| title_sort | polymorphisms of the apolipoprotein e gene affect response to atorvastatin therapy in acute ischemic stroke |
| topic | apolipoprotein E polymorphism lipid-lowering atherosclerosis carotid artery plaques |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1024014/full |
| work_keys_str_mv | AT qianqianbi polymorphismsoftheapolipoproteinegeneaffectresponsetoatorvastatintherapyinacuteischemicstroke AT xiaoyuzhou polymorphismsoftheapolipoproteinegeneaffectresponsetoatorvastatintherapyinacuteischemicstroke AT yanqinlu polymorphismsoftheapolipoproteinegeneaffectresponsetoatorvastatintherapyinacuteischemicstroke AT wangfu polymorphismsoftheapolipoproteinegeneaffectresponsetoatorvastatintherapyinacuteischemicstroke AT yongpengwang polymorphismsoftheapolipoproteinegeneaffectresponsetoatorvastatintherapyinacuteischemicstroke AT fengwang polymorphismsoftheapolipoproteinegeneaffectresponsetoatorvastatintherapyinacuteischemicstroke AT juewang polymorphismsoftheapolipoproteinegeneaffectresponsetoatorvastatintherapyinacuteischemicstroke |