Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer
ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin Am...
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| Language: | English |
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Sociedade Brasileira de Urologia
2023-09-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382023000500580&tlng=en |
| _version_ | 1797692741002461184 |
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| author | Marcos Tobias-Machado Antonio A. Ornellas Alexandre K. Hidaka Luis G. Medina Pablo A. L. Mattos Ruben S. Besio Diego Abreu Pedro R. Castro Ricardo H. Nishimoto Juan Astigueta Aurus Dourado Roberto D. Machado Wesley J. Magnabosco Victor Corona-Montes Gustavo M. Villoldo Hamilton C. Zampolli Anis Taha Pericles R. Auad Eliney F. Faria Paulo B. O. Arantes Alessandro Tavares Francisco S. M. S. Nascimento Eder S. Brazão Jr. Maurício M. Rocha Walter H. Costa Vinicius Panico Leonardo O. Reis Roberto J. Almeida-Carrera Rafael C. Silva Stênio C. Zequi José R. R. Calixto Rene Sotelo |
| author_facet | Marcos Tobias-Machado Antonio A. Ornellas Alexandre K. Hidaka Luis G. Medina Pablo A. L. Mattos Ruben S. Besio Diego Abreu Pedro R. Castro Ricardo H. Nishimoto Juan Astigueta Aurus Dourado Roberto D. Machado Wesley J. Magnabosco Victor Corona-Montes Gustavo M. Villoldo Hamilton C. Zampolli Anis Taha Pericles R. Auad Eliney F. Faria Paulo B. O. Arantes Alessandro Tavares Francisco S. M. S. Nascimento Eder S. Brazão Jr. Maurício M. Rocha Walter H. Costa Vinicius Panico Leonardo O. Reis Roberto J. Almeida-Carrera Rafael C. Silva Stênio C. Zequi José R. R. Calixto Rene Sotelo |
| author_sort | Marcos Tobias-Machado |
| collection | DOAJ |
| description | ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer. |
| first_indexed | 2024-03-12T02:32:02Z |
| format | Article |
| id | doaj.art-8dd2bbae3f224be3bbb20cefb6994895 |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-03-12T02:32:02Z |
| publishDate | 2023-09-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-8dd2bbae3f224be3bbb20cefb69948952023-09-05T07:41:14ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61192023-09-0149558058910.1590/s1677-5538.ibju.2023.0065Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancerMarcos Tobias-MachadoAntonio A. Ornellashttps://orcid.org/0000-0002-6497-511XAlexandre K. HidakaLuis G. MedinaPablo A. L. MattosRuben S. BesioDiego AbreuPedro R. CastroRicardo H. NishimotoJuan AstiguetaAurus DouradoRoberto D. MachadoWesley J. MagnaboscoVictor Corona-MontesGustavo M. VilloldoHamilton C. ZampolliAnis TahaPericles R. AuadEliney F. FariaPaulo B. O. ArantesAlessandro TavaresFrancisco S. M. S. NascimentoEder S. Brazão Jr.Maurício M. RochaWalter H. CostaVinicius PanicoLeonardo O. ReisRoberto J. Almeida-CarreraRafael C. SilvaStênio C. ZequiJosé R. R. CalixtoRene SoteloABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382023000500580&tlng=enMinimally Invasive Surgical ProceduresLaparoscopyPenis |
| spellingShingle | Marcos Tobias-Machado Antonio A. Ornellas Alexandre K. Hidaka Luis G. Medina Pablo A. L. Mattos Ruben S. Besio Diego Abreu Pedro R. Castro Ricardo H. Nishimoto Juan Astigueta Aurus Dourado Roberto D. Machado Wesley J. Magnabosco Victor Corona-Montes Gustavo M. Villoldo Hamilton C. Zampolli Anis Taha Pericles R. Auad Eliney F. Faria Paulo B. O. Arantes Alessandro Tavares Francisco S. M. S. Nascimento Eder S. Brazão Jr. Maurício M. Rocha Walter H. Costa Vinicius Panico Leonardo O. Reis Roberto J. Almeida-Carrera Rafael C. Silva Stênio C. Zequi José R. R. Calixto Rene Sotelo Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer International Brazilian Journal of Urology Minimally Invasive Surgical Procedures Laparoscopy Penis |
| title | Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer |
| title_full | Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer |
| title_fullStr | Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer |
| title_full_unstemmed | Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer |
| title_short | Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer |
| title_sort | long term oncological and surgical outcomes after video endoscopic inguinal lymphadenectomy veil in patients with penile cancer |
| topic | Minimally Invasive Surgical Procedures Laparoscopy Penis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382023000500580&tlng=en |
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