Structure-function studies using deletion mutants identify domains of gC1qR/p33 as potential therapeutic targets for vascular permeability and inflammation#.

Structure-function studies using deletion mutants identify domains of gC1qR/p33 as potential therapeutic targets for vascular permeability and inflammation#.

The endothelial cell (EC) receptor complex for kininogen (HK) comprises gC1qR, cytokeratin 1, and urokinase-type plasminogen activator receptor (uPAR) and is essential for activation of the kinin system that leads to bradykinin (BK) generation. Of these, gC1qR/p33 constitutes a high affinity site fo...

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Bibliographic Details
Main Authors: Berhane eGhebrehiwet, Jolyon eJesty, Sulan eXu, Rama eVinayagasundaram, Uma eVinayagasundaram, Yan eJi, Alisa eValentino, Kinga H. Hosszu, Sally eMathew, Kusumam eJoseph, Allen P. Kaplan, Ellinor I.B. Peerschke
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-11-01
Series:Frontiers in Immunology
Subjects:
Bradykinin
Inflammation
Vascular permeability
gC1qR
kininogen
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00058/full

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