Comparative effectiveness and safety of direct oral anticoagulants versus warfarin among patients with recurrent venous thromboembolism
Abstract The comparative effectiveness and safety of oral anticoagulant therapies to prevent a second recurrent venous thromboembolism (VTE) remains undetermined. We aimed to compare the benefits and harms of direct oral anticoagulant (DOAC) and warfarin therapies in preventing second recurrent VTE...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Clinical and Translational Science |
| Online Access: | https://doi.org/10.1111/cts.13510 |
| _version_ | 1797804469814034432 |
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| author | Hye‐Rim Kang Eric A. Dietrich Pei‐Lin Huang Wei‐Hsuan Lo‐Ciganic Christina E. DeRemer Haesuk Park |
| author_facet | Hye‐Rim Kang Eric A. Dietrich Pei‐Lin Huang Wei‐Hsuan Lo‐Ciganic Christina E. DeRemer Haesuk Park |
| author_sort | Hye‐Rim Kang |
| collection | DOAJ |
| description | Abstract The comparative effectiveness and safety of oral anticoagulant therapies to prevent a second recurrent venous thromboembolism (VTE) remains undetermined. We aimed to compare the benefits and harms of direct oral anticoagulant (DOAC) and warfarin therapies in preventing second recurrent VTE and major bleeding events among patients with a recurrent VTE episode following anticoagulation therapy for incident VTE. A retrospective cohort analysis of two large national insurance claims databases was conducted for patients with two episodes of VTE. Cox proportional hazards models were used after inverse probability treatment weighting to compare risks of second recurrent VTE and major bleeding events. Compared with warfarin, DOAC therapy was associated with significantly decreased risk of second recurrent VTE with no significant difference in risk of major bleeding events. Our findings suggest that, compared with warfarin, DOACs may reduce risk of second VTE recurrence among patients who have experienced one recurrence. |
| first_indexed | 2024-03-13T05:37:38Z |
| format | Article |
| id | doaj.art-8dd651ba69854081b4efc1c5379f73ce |
| institution | Directory Open Access Journal |
| issn | 1752-8054 1752-8062 |
| language | English |
| last_indexed | 2024-03-13T05:37:38Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Science |
| spelling | doaj.art-8dd651ba69854081b4efc1c5379f73ce2023-06-14T06:03:57ZengWileyClinical and Translational Science1752-80541752-80622023-06-0116694695410.1111/cts.13510Comparative effectiveness and safety of direct oral anticoagulants versus warfarin among patients with recurrent venous thromboembolismHye‐Rim Kang0Eric A. Dietrich1Pei‐Lin Huang2Wei‐Hsuan Lo‐Ciganic3Christina E. DeRemer4Haesuk Park5Department of Pharmaceutical Outcomes and Policy, College of Pharmacy University of Florida Gainesville Florida USADepartment of Pharmacotherapy and Translational Research, College of Pharmacy University of Florida Gainesville Florida USADepartment of Pharmaceutical Outcomes and Policy, College of Pharmacy University of Florida Gainesville Florida USADepartment of Pharmaceutical Outcomes and Policy, College of Pharmacy University of Florida Gainesville Florida USADepartment of Pharmacotherapy and Translational Research, College of Pharmacy University of Florida Gainesville Florida USADepartment of Pharmaceutical Outcomes and Policy, College of Pharmacy University of Florida Gainesville Florida USAAbstract The comparative effectiveness and safety of oral anticoagulant therapies to prevent a second recurrent venous thromboembolism (VTE) remains undetermined. We aimed to compare the benefits and harms of direct oral anticoagulant (DOAC) and warfarin therapies in preventing second recurrent VTE and major bleeding events among patients with a recurrent VTE episode following anticoagulation therapy for incident VTE. A retrospective cohort analysis of two large national insurance claims databases was conducted for patients with two episodes of VTE. Cox proportional hazards models were used after inverse probability treatment weighting to compare risks of second recurrent VTE and major bleeding events. Compared with warfarin, DOAC therapy was associated with significantly decreased risk of second recurrent VTE with no significant difference in risk of major bleeding events. Our findings suggest that, compared with warfarin, DOACs may reduce risk of second VTE recurrence among patients who have experienced one recurrence.https://doi.org/10.1111/cts.13510 |
| spellingShingle | Hye‐Rim Kang Eric A. Dietrich Pei‐Lin Huang Wei‐Hsuan Lo‐Ciganic Christina E. DeRemer Haesuk Park Comparative effectiveness and safety of direct oral anticoagulants versus warfarin among patients with recurrent venous thromboembolism Clinical and Translational Science |
| title | Comparative effectiveness and safety of direct oral anticoagulants versus warfarin among patients with recurrent venous thromboembolism |
| title_full | Comparative effectiveness and safety of direct oral anticoagulants versus warfarin among patients with recurrent venous thromboembolism |
| title_fullStr | Comparative effectiveness and safety of direct oral anticoagulants versus warfarin among patients with recurrent venous thromboembolism |
| title_full_unstemmed | Comparative effectiveness and safety of direct oral anticoagulants versus warfarin among patients with recurrent venous thromboembolism |
| title_short | Comparative effectiveness and safety of direct oral anticoagulants versus warfarin among patients with recurrent venous thromboembolism |
| title_sort | comparative effectiveness and safety of direct oral anticoagulants versus warfarin among patients with recurrent venous thromboembolism |
| url | https://doi.org/10.1111/cts.13510 |
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