The relationship between the polymorphisms of the gene and hypertension: A meta-analysis
Objective: With the development of genome-wide association studies (GWAS) concerning hypertension, a growing number of susceptibility genes related to hypertension have been revealed. Subsequently, several studies have investigated the association between CYP17A1 rs1004467 heritable variation and hy...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
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SAGE Publications
2015-12-01
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Series: | Journal of the Renin-Angiotensin-Aldosterone System |
Online Access: | https://doi.org/10.1177/1470320315585683 |
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author | Chuan-Fang Dai Xiang Xie Yi-Tong Ma Yi-Ning Yang Xiao-Mei Li Zhen-Yan Fu Fen Liu Bang-Dang Chen Min-Tao Gai |
author_facet | Chuan-Fang Dai Xiang Xie Yi-Tong Ma Yi-Ning Yang Xiao-Mei Li Zhen-Yan Fu Fen Liu Bang-Dang Chen Min-Tao Gai |
author_sort | Chuan-Fang Dai |
collection | DOAJ |
description | Objective: With the development of genome-wide association studies (GWAS) concerning hypertension, a growing number of susceptibility genes related to hypertension have been revealed. Subsequently, several studies have investigated the association between CYP17A1 rs1004467 heritable variation and hypertension; however, the results have been inconsistent. In this study, a meta-analysis was performed to assess the association between the CYP17A1 rs1004467 polymorphism and hypertension risk. Methods: The PubMed, ISI Web of Science and Embase databases as well as China Wanfang, Weipu and the Chinese Journal Full-text Database were used to retrieve all publications from 2005 to 2013 related to case-control studies that reported a link between the risk factors for hypertension and the CYP17A1 polymorphism. All association studies were identified, and a meta-analysis was conducted using the RevMan 5.0 estimate for odds ratios (ORs) to determine whether the A allele predicts hypertension outcomes. Results: Three articles including five studies (totaling 4495 patients and 3529 controls) were identified. The overall effect suggested that rs1004467 was significantly associated with hypertension (OR=1.22, 95%CI 1.08–1.38, p =0.001). Conclusions: The present meta-analysis confirmed the significant association between a polymorphism of the CYP17A1 gene and hypertension susceptibility. The CYP17A1 A allele should be considered a risk factor for hypertension. |
first_indexed | 2024-03-07T18:07:38Z |
format | Article |
id | doaj.art-8dd756511b8548d48e6f143e31310f67 |
institution | Directory Open Access Journal |
issn | 1470-3203 1752-8976 |
language | English |
last_indexed | 2024-03-07T18:07:38Z |
publishDate | 2015-12-01 |
publisher | SAGE Publications |
record_format | Article |
series | Journal of the Renin-Angiotensin-Aldosterone System |
spelling | doaj.art-8dd756511b8548d48e6f143e31310f672024-03-02T08:34:53ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762015-12-011610.1177/1470320315585683The relationship between the polymorphisms of the gene and hypertension: A meta-analysisChuan-Fang DaiXiang XieYi-Tong MaYi-Ning YangXiao-Mei LiZhen-Yan FuFen LiuBang-Dang ChenMin-Tao GaiObjective: With the development of genome-wide association studies (GWAS) concerning hypertension, a growing number of susceptibility genes related to hypertension have been revealed. Subsequently, several studies have investigated the association between CYP17A1 rs1004467 heritable variation and hypertension; however, the results have been inconsistent. In this study, a meta-analysis was performed to assess the association between the CYP17A1 rs1004467 polymorphism and hypertension risk. Methods: The PubMed, ISI Web of Science and Embase databases as well as China Wanfang, Weipu and the Chinese Journal Full-text Database were used to retrieve all publications from 2005 to 2013 related to case-control studies that reported a link between the risk factors for hypertension and the CYP17A1 polymorphism. All association studies were identified, and a meta-analysis was conducted using the RevMan 5.0 estimate for odds ratios (ORs) to determine whether the A allele predicts hypertension outcomes. Results: Three articles including five studies (totaling 4495 patients and 3529 controls) were identified. The overall effect suggested that rs1004467 was significantly associated with hypertension (OR=1.22, 95%CI 1.08–1.38, p =0.001). Conclusions: The present meta-analysis confirmed the significant association between a polymorphism of the CYP17A1 gene and hypertension susceptibility. The CYP17A1 A allele should be considered a risk factor for hypertension.https://doi.org/10.1177/1470320315585683 |
spellingShingle | Chuan-Fang Dai Xiang Xie Yi-Tong Ma Yi-Ning Yang Xiao-Mei Li Zhen-Yan Fu Fen Liu Bang-Dang Chen Min-Tao Gai The relationship between the polymorphisms of the gene and hypertension: A meta-analysis Journal of the Renin-Angiotensin-Aldosterone System |
title | The relationship between the polymorphisms of the gene and hypertension: A meta-analysis |
title_full | The relationship between the polymorphisms of the gene and hypertension: A meta-analysis |
title_fullStr | The relationship between the polymorphisms of the gene and hypertension: A meta-analysis |
title_full_unstemmed | The relationship between the polymorphisms of the gene and hypertension: A meta-analysis |
title_short | The relationship between the polymorphisms of the gene and hypertension: A meta-analysis |
title_sort | relationship between the polymorphisms of the gene and hypertension a meta analysis |
url | https://doi.org/10.1177/1470320315585683 |
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