Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain <i>Pleosporales</i> sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes

Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain <i>Pleosporales</i> sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes

Atopic dermatitis (AD) is a chronic inflammatory skin disease with a profound negative impact on patients’ quality of life. Four known secondary fungal metabolites were found in the chemical study of the Antarctic fungus <i>Pleosporales</i> sp. SF-7343, including 14-methoxyalternate C (&...

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Bibliographic Details
Main Authors: Linsha Dong, Thao Quyen Cao, Zhiming Liu, Nguyen Quoc Tuan, Youn-Chul Kim, Jae Hak Sohn, Joung Han Yim, Dong-Sung Lee, Hyuncheol Oh
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
Antarctic fungi
skin inflammation
JAK2/STAT3
NF-κB
HaCaT
Online Access:https://www.mdpi.com/1422-0067/23/23/14642

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