Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers

Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers

Abstract Immune checkpoint inhibitors (ICI) are highly effective in specific cancers where canonical markers of antitumor immunity are used for patient selection. Improved predictors of T cell-inflammation are needed to identify ICI-responsive tumor subsets in additional cancer types. We investigate...

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Bibliographic Details
Main Authors: Joan Miguel Romero, Emma Titmuss, Yifan Wang, James Vafiadis, Alain Pacis, Gun Ho Jang, Amy Zhang, Bryn Golesworthy, Tatiana Lenko, Laura M. Williamson, Barbara Grünwald, Grainne M. O’Kane, Steven J. M. Jones, Marco. A. Marra, Julie M. Wilson, Steven Gallinger, Janessa Laskin, George Zogopoulos
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-023-00428-2

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