Nutritional Profile, Antioxidative and Antihyperglycemic Properties of <i>Padina tetrastromatica</i> from Tioman Island, Malaysia
Seaweeds are an important ingredient of functional foods recommended for daily food, due to their unique compositions and nutritional value. <i>Padina tetrastromatica</i> is a brown edible seaweed that is commonly found along the coastal regions of Peninsular Malaysia and consumed as foo...
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MDPI AG
2021-08-01
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| Online Access: | https://www.mdpi.com/2304-8158/10/8/1932 |
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| author | Kishneth Palaniveloo Liaw Yee-Yinn Leong Jia-Qi Alvin Chelliah Song Sze-Looi Thilahgavani Nagappan Shariza Abdul Razak Kamal Dua Jestin Chellian Dinesh Kumar Chellappan Anil Philip Kunnath |
| author_facet | Kishneth Palaniveloo Liaw Yee-Yinn Leong Jia-Qi Alvin Chelliah Song Sze-Looi Thilahgavani Nagappan Shariza Abdul Razak Kamal Dua Jestin Chellian Dinesh Kumar Chellappan Anil Philip Kunnath |
| author_sort | Kishneth Palaniveloo |
| collection | DOAJ |
| description | Seaweeds are an important ingredient of functional foods recommended for daily food, due to their unique compositions and nutritional value. <i>Padina tetrastromatica</i> is a brown edible seaweed that is commonly found along the coastal regions of Peninsular Malaysia and consumed as food by some coastal communities. This study investigates the nutritional and antihyperglycaemic potential of <i>P. tetrastromatica</i> extracts, which is generally accepted as an important functional food. In our methodology, we induced diabetes intraperitoneally in experimental animals with a dose of 65 mg kg<sup>−1</sup> body weight of streptozotocin. Oral treatment with 200 and 400 mg kg<sup>−1</sup> of <i>P. tetrastromatica</i> ethanolic and ethyl acetate extracts were initiated, respectively, to experimental rats once daily for 18 days. Metformin was used as the positive control. Biochemical estimations and histopathological analysis were included in this study. Treatment with <i>P. tetrastromatica</i> extracts significantly lowered the plasma glucose levels in Streptozotocin-induced diabetic rats. In addition, <i>P. tetrastromatica</i> extract treatment also showed a significant reduction in serum alanine transaminase levels. However, no significant changes were observed in serum aspartate transaminase levels. The ethyl acetate extract of <i>P. tetrastromatica</i> at 400 mg kg<sup>−1</sup> dose shows some nephroprotective effect, which is observed from the significant increase in the plasma albumin levels. Histopathological evaluation revealed no marked morphological changes in tissues of the isolated organs of the ethyl acetate extract-treated group, revealing the safe nature of <i>P. tetrastromatica</i>. |
| first_indexed | 2024-03-10T08:48:52Z |
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| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T08:48:52Z |
| publishDate | 2021-08-01 |
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| spelling | doaj.art-8dd8e0238fea45a7af50916f85d743992023-11-22T07:40:59ZengMDPI AGFoods2304-81582021-08-01108193210.3390/foods10081932Nutritional Profile, Antioxidative and Antihyperglycemic Properties of <i>Padina tetrastromatica</i> from Tioman Island, MalaysiaKishneth Palaniveloo0Liaw Yee-Yinn1Leong Jia-Qi2Alvin Chelliah3Song Sze-Looi4Thilahgavani Nagappan5Shariza Abdul Razak6Kamal Dua7Jestin Chellian8Dinesh Kumar Chellappan9Anil Philip Kunnath10Institute of Ocean and Earth Sciences, Universiti Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Life Sciences, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaDepartment of Life Sciences, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaReef Check Malaysia, Suite 5.19–5.22, Wisma Central, Jalan Ampang, Kuala Lumpur 50450, MalaysiaInstitute for Advanced Studies, Universiti Malaya, Kuala Lumpur 50603, MalaysiaSchool of Marine and Environmental Sciences, Universiti Malaysia Terengganu, Kuala Terengganu 21030, MalaysiaNutrition and Dietetics Program, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, MalaysiaDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, AustraliaDepartment of Life Sciences, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaDepartment of Life Sciences, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaDivision of Applied Biomedical Science and Biotechnology, School of Health Sciences, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaSeaweeds are an important ingredient of functional foods recommended for daily food, due to their unique compositions and nutritional value. <i>Padina tetrastromatica</i> is a brown edible seaweed that is commonly found along the coastal regions of Peninsular Malaysia and consumed as food by some coastal communities. This study investigates the nutritional and antihyperglycaemic potential of <i>P. tetrastromatica</i> extracts, which is generally accepted as an important functional food. In our methodology, we induced diabetes intraperitoneally in experimental animals with a dose of 65 mg kg<sup>−1</sup> body weight of streptozotocin. Oral treatment with 200 and 400 mg kg<sup>−1</sup> of <i>P. tetrastromatica</i> ethanolic and ethyl acetate extracts were initiated, respectively, to experimental rats once daily for 18 days. Metformin was used as the positive control. Biochemical estimations and histopathological analysis were included in this study. Treatment with <i>P. tetrastromatica</i> extracts significantly lowered the plasma glucose levels in Streptozotocin-induced diabetic rats. In addition, <i>P. tetrastromatica</i> extract treatment also showed a significant reduction in serum alanine transaminase levels. However, no significant changes were observed in serum aspartate transaminase levels. The ethyl acetate extract of <i>P. tetrastromatica</i> at 400 mg kg<sup>−1</sup> dose shows some nephroprotective effect, which is observed from the significant increase in the plasma albumin levels. Histopathological evaluation revealed no marked morphological changes in tissues of the isolated organs of the ethyl acetate extract-treated group, revealing the safe nature of <i>P. tetrastromatica</i>.https://www.mdpi.com/2304-8158/10/8/1932seaweedbrown algae<i>Padina tetrastromatica</i>Tioman Islandfunctional foodnutrition |
| spellingShingle | Kishneth Palaniveloo Liaw Yee-Yinn Leong Jia-Qi Alvin Chelliah Song Sze-Looi Thilahgavani Nagappan Shariza Abdul Razak Kamal Dua Jestin Chellian Dinesh Kumar Chellappan Anil Philip Kunnath Nutritional Profile, Antioxidative and Antihyperglycemic Properties of <i>Padina tetrastromatica</i> from Tioman Island, Malaysia Foods seaweed brown algae <i>Padina tetrastromatica</i> Tioman Island functional food nutrition |
| title | Nutritional Profile, Antioxidative and Antihyperglycemic Properties of <i>Padina tetrastromatica</i> from Tioman Island, Malaysia |
| title_full | Nutritional Profile, Antioxidative and Antihyperglycemic Properties of <i>Padina tetrastromatica</i> from Tioman Island, Malaysia |
| title_fullStr | Nutritional Profile, Antioxidative and Antihyperglycemic Properties of <i>Padina tetrastromatica</i> from Tioman Island, Malaysia |
| title_full_unstemmed | Nutritional Profile, Antioxidative and Antihyperglycemic Properties of <i>Padina tetrastromatica</i> from Tioman Island, Malaysia |
| title_short | Nutritional Profile, Antioxidative and Antihyperglycemic Properties of <i>Padina tetrastromatica</i> from Tioman Island, Malaysia |
| title_sort | nutritional profile antioxidative and antihyperglycemic properties of i padina tetrastromatica i from tioman island malaysia |
| topic | seaweed brown algae <i>Padina tetrastromatica</i> Tioman Island functional food nutrition |
| url | https://www.mdpi.com/2304-8158/10/8/1932 |
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