Transient ischemic attacks as the first presentation of JAK2-V617F positive chronic myeloproliferative neoplasm
Several studies have shown that thrombotic events may underlie a latent or subclinical myeloproliferative neoplasm (MPN) and precede its definite diagnosis by 1–2 years. An early diagnosis of patients with MPN, especially those with thrombotic events in the latent MPN phase, would be beneficial for...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-06-01
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| Series: | Hematology Reports |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/hr/article/view/4164 |
| _version_ | 1797936838032228352 |
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| author | Fani Kalala Antigoni Mamara Maria Ioannou Matthaios Speletas |
| author_facet | Fani Kalala Antigoni Mamara Maria Ioannou Matthaios Speletas |
| author_sort | Fani Kalala |
| collection | DOAJ |
| description | Several studies have shown that thrombotic events may underlie a latent or subclinical myeloproliferative neoplasm (MPN) and precede its definite diagnosis by 1–2 years. An early diagnosis of patients with MPN, especially those with thrombotic events in the latent MPN phase, would be beneficial for their management, preventing further morbidity and improving their quality of life. For the majority of these cases, the location of thrombosis is mainly in the splanchnic major veins, while ischemic stroke and cerebral venous thrombosis are rarely observed. In this report, we present a female patient with transient ischemic attacks who suffered from a latent MPN, on the basis of a positive testing for the JAK2-V617F mutation. |
| first_indexed | 2024-04-10T18:35:37Z |
| format | Article |
| id | doaj.art-8dd9425ad7fa4ac48336d40c2aa5f6e0 |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:35:37Z |
| publishDate | 2012-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-8dd9425ad7fa4ac48336d40c2aa5f6e02023-02-02T01:42:07ZengMDPI AGHematology Reports2038-83222038-83302012-06-0142e12e1210.4081/hr.2012.e122191Transient ischemic attacks as the first presentation of JAK2-V617F positive chronic myeloproliferative neoplasmFani Kalala0Antigoni Mamara1Maria Ioannou2Matthaios Speletas3Department of Immunology and Histocompatibility, University of Thessaly, Faculty of Medicine, LarissaDepartment of Immunology and Histocompatibility, University of Thessaly, Faculty of Medicine, LarissaDepartment of Pathology, University of Thessaly, Faculty of Medicine, LarissaDepartment of Immunology and Histocompatibility, University of Thessaly, Faculty of Medicine, LarissaSeveral studies have shown that thrombotic events may underlie a latent or subclinical myeloproliferative neoplasm (MPN) and precede its definite diagnosis by 1–2 years. An early diagnosis of patients with MPN, especially those with thrombotic events in the latent MPN phase, would be beneficial for their management, preventing further morbidity and improving their quality of life. For the majority of these cases, the location of thrombosis is mainly in the splanchnic major veins, while ischemic stroke and cerebral venous thrombosis are rarely observed. In this report, we present a female patient with transient ischemic attacks who suffered from a latent MPN, on the basis of a positive testing for the JAK2-V617F mutation.http://www.pagepress.org/journals/index.php/hr/article/view/4164TIAs, latent myeloproliferative neoplasm, JAK2-V617F |
| spellingShingle | Fani Kalala Antigoni Mamara Maria Ioannou Matthaios Speletas Transient ischemic attacks as the first presentation of JAK2-V617F positive chronic myeloproliferative neoplasm Hematology Reports TIAs, latent myeloproliferative neoplasm, JAK2-V617F |
| title | Transient ischemic attacks as the first presentation of JAK2-V617F positive chronic myeloproliferative neoplasm |
| title_full | Transient ischemic attacks as the first presentation of JAK2-V617F positive chronic myeloproliferative neoplasm |
| title_fullStr | Transient ischemic attacks as the first presentation of JAK2-V617F positive chronic myeloproliferative neoplasm |
| title_full_unstemmed | Transient ischemic attacks as the first presentation of JAK2-V617F positive chronic myeloproliferative neoplasm |
| title_short | Transient ischemic attacks as the first presentation of JAK2-V617F positive chronic myeloproliferative neoplasm |
| title_sort | transient ischemic attacks as the first presentation of jak2 v617f positive chronic myeloproliferative neoplasm |
| topic | TIAs, latent myeloproliferative neoplasm, JAK2-V617F |
| url | http://www.pagepress.org/journals/index.php/hr/article/view/4164 |
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