Human umbilical cord mesenchymal stem cells conditioned medium exerts anti-tumor effects on KGN cells in a cell density-dependent manner through activation of the Hippo pathway

Human umbilical cord mesenchymal stem cells conditioned medium exerts anti-tumor effects on KGN cells in a cell density-dependent manner through activation of the Hippo pathway

Abstract Background The conditioned medium from human umbilical cord mesenchymal stem cells (UCMSCs-CM) provides a new cell-free therapy for tumors due to its unique secretome. However, there are many contradictory reports about the effect of UCMSCs-CM on tumor cells. The loss of contact inhibition...

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Bibliographic Details
Main Authors: Wenjing Wan, Yuyang Miao, Yuwei Niu, Kunyuan Zhu, Yingwan Ma, Menghao Pan, Baohua Ma, Qiang Wei
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Stem Cell Research & Therapy
Subjects:
Human umbilical cord mesenchymal stem cells
Conditioned medium
Granulosa cell tumor
Cell density
Contact inhibition
Hippo pathway
Online Access:https://doi.org/10.1186/s13287-023-03273-z

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