A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein
Current Zika virus (ZIKV) subunit vaccine development largely focuses on prM and E proteins, and the role of NS1 for immune response and protection is unclear. Here, Li et al. develop an attenuated VSV-based vaccine expressing a ZIKV prM-E-NS1 polyprotein and characterize immune response and protect...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05276-4 |
| _version_ | 1830209768369684480 |
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| author | Anzhong Li Jingyou Yu Mijia Lu Yuanmei Ma Zayed Attia Chao Shan Miaoge Xue Xueya Liang Kelsey Craig Nirajkumar Makadiya Jennifer J. He Ryan Jennings Pei-Yong Shi Mark E. Peeples Shan-Lu Liu Prosper N. Boyaka Jianrong Li |
| author_facet | Anzhong Li Jingyou Yu Mijia Lu Yuanmei Ma Zayed Attia Chao Shan Miaoge Xue Xueya Liang Kelsey Craig Nirajkumar Makadiya Jennifer J. He Ryan Jennings Pei-Yong Shi Mark E. Peeples Shan-Lu Liu Prosper N. Boyaka Jianrong Li |
| author_sort | Anzhong Li |
| collection | DOAJ |
| description | Current Zika virus (ZIKV) subunit vaccine development largely focuses on prM and E proteins, and the role of NS1 for immune response and protection is unclear. Here, Li et al. develop an attenuated VSV-based vaccine expressing a ZIKV prM-E-NS1 polyprotein and characterize immune response and protection in mice. |
| first_indexed | 2024-12-18T05:14:01Z |
| format | Article |
| id | doaj.art-8dda5bf46f8146d19d1bf7be27066060 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T05:14:01Z |
| publishDate | 2018-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8dda5bf46f8146d19d1bf7be270660602022-12-21T21:19:48ZengNature PortfolioNature Communications2041-17232018-08-019111710.1038/s41467-018-05276-4A Zika virus vaccine expressing premembrane-envelope-NS1 polyproteinAnzhong Li0Jingyou Yu1Mijia Lu2Yuanmei Ma3Zayed Attia4Chao Shan5Miaoge Xue6Xueya Liang7Kelsey Craig8Nirajkumar Makadiya9Jennifer J. He10Ryan Jennings11Pei-Yong Shi12Mark E. Peeples13Shan-Lu Liu14Prosper N. Boyaka15Jianrong Li16Department of Veterinary Biosciences, The Ohio State UniversityDepartment of Veterinary Biosciences, The Ohio State UniversityDepartment of Veterinary Biosciences, The Ohio State UniversityDepartment of Veterinary Biosciences, The Ohio State UniversityDepartment of Veterinary Biosciences, The Ohio State UniversityDepartment of Biochemistry & Molecular Biology, Department of Pharmacology & Toxicology, and Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical BranchDepartment of Veterinary Biosciences, The Ohio State UniversityDepartment of Veterinary Biosciences, The Ohio State UniversityDepartment of Veterinary Biosciences, The Ohio State UniversityDepartment of Veterinary Biosciences, The Ohio State UniversityDepartment of Veterinary Biosciences, The Ohio State UniversityDepartment of Veterinary Biosciences, The Ohio State UniversityDepartment of Biochemistry & Molecular Biology, Department of Pharmacology & Toxicology, and Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical BranchCenter for Vaccines and Immunity, The Research Institute at Nationwide Children’s HospitalDepartment of Veterinary Biosciences, The Ohio State UniversityDepartment of Veterinary Biosciences, The Ohio State UniversityDepartment of Veterinary Biosciences, The Ohio State UniversityCurrent Zika virus (ZIKV) subunit vaccine development largely focuses on prM and E proteins, and the role of NS1 for immune response and protection is unclear. Here, Li et al. develop an attenuated VSV-based vaccine expressing a ZIKV prM-E-NS1 polyprotein and characterize immune response and protection in mice.https://doi.org/10.1038/s41467-018-05276-4 |
| spellingShingle | Anzhong Li Jingyou Yu Mijia Lu Yuanmei Ma Zayed Attia Chao Shan Miaoge Xue Xueya Liang Kelsey Craig Nirajkumar Makadiya Jennifer J. He Ryan Jennings Pei-Yong Shi Mark E. Peeples Shan-Lu Liu Prosper N. Boyaka Jianrong Li A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein Nature Communications |
| title | A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein |
| title_full | A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein |
| title_fullStr | A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein |
| title_full_unstemmed | A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein |
| title_short | A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein |
| title_sort | zika virus vaccine expressing premembrane envelope ns1 polyprotein |
| url | https://doi.org/10.1038/s41467-018-05276-4 |
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