Vasoactive intestinal peptide in canine portosystemic shunt in the absence of portal hypertension
Background: The congenital portosystemic shunt (PSS) is a common vascular anomaly in dogs. Vasoactive intestinal peptide (VIP) is produced in various organs (including the small intestine, large intestine, and pancreas), leading to abdominal vasodilation, increased blood flow, increased pancreatic b...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tripoli University
2021-01-01
|
| Series: | Open Veterinary Journal |
| Subjects: | |
| Online Access: | https://www.openveterinaryjournal.com/OVJ-2020-11-323%20M.%20Isaka%20and%20H.%20Ueno.pdf |
| _version_ | 1818890984715452416 |
|---|---|
| author | Mitsuhiro Isaka Hiroshi Ueno |
| author_facet | Mitsuhiro Isaka Hiroshi Ueno |
| author_sort | Mitsuhiro Isaka |
| collection | DOAJ |
| description | Background: The congenital portosystemic shunt (PSS) is a common vascular anomaly in dogs. Vasoactive intestinal peptide (VIP) is produced in various organs (including the small intestine, large intestine, and pancreas), leading to abdominal vasodilation, increased blood flow, increased pancreatic blood flow, and promotion of pancreatic endocrine and exocrine secretion. However, there have been no reports on the concentration of VIP in the portal and peripheral veins in canine PSS.
Aim: The aim of this pilot study was to evaluate whether dogs with PSS have a different VIP concentration in their portal system in general.
Methods: Six dogs with an extrahepatic portosplenic shunt were included in the study. Blood samples were taken from the saphenous and portal vein during PSS ligation surgery with an amerid constrictor, to evaluate and compare the VIP concentration in both samples. VIP was measured using a commercial canine enzyme-linked immunosorbent assay kit.
Results: The breeds included Mongrels (n = 2), Norfolk Terriers (n = 1), Miniature Dachshunds (n = 1), and Maltese (n = 2), and their ages were 9.3 ± 6.5 months; the bodyweight was 3.3 ± 0.8 kg. The concentration of VIP in the saphenous vein was 17.75 ± 13.88 pg/mL; in contrast, the concentration of VIP in the portal vein was 29.7 ± 20.29 pg/mL. There was no significant difference in the VIP concentration between veins.
Conclusion: There was no difference in the VIP concentration between the portal and saphenous veins, suggesting non-association between VIP and the PSS, in the absence of portal hypertension. |
| first_indexed | 2024-12-19T17:33:36Z |
| format | Article |
| id | doaj.art-8ddf04d8b0a34a50afdf58e9ae37cd8f |
| institution | Directory Open Access Journal |
| issn | 2218-6050 2218-6050 |
| language | English |
| last_indexed | 2024-12-19T17:33:36Z |
| publishDate | 2021-01-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-8ddf04d8b0a34a50afdf58e9ae37cd8f2022-12-21T20:12:24ZengTripoli UniversityOpen Veterinary Journal2218-60502218-60502021-01-011113941http://dx.doi.org/10.4314/ovj.v11i1.7Vasoactive intestinal peptide in canine portosystemic shunt in the absence of portal hypertensionMitsuhiro Isaka0Hiroshi Ueno1Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, JapanDepartment of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, JapanBackground: The congenital portosystemic shunt (PSS) is a common vascular anomaly in dogs. Vasoactive intestinal peptide (VIP) is produced in various organs (including the small intestine, large intestine, and pancreas), leading to abdominal vasodilation, increased blood flow, increased pancreatic blood flow, and promotion of pancreatic endocrine and exocrine secretion. However, there have been no reports on the concentration of VIP in the portal and peripheral veins in canine PSS. Aim: The aim of this pilot study was to evaluate whether dogs with PSS have a different VIP concentration in their portal system in general. Methods: Six dogs with an extrahepatic portosplenic shunt were included in the study. Blood samples were taken from the saphenous and portal vein during PSS ligation surgery with an amerid constrictor, to evaluate and compare the VIP concentration in both samples. VIP was measured using a commercial canine enzyme-linked immunosorbent assay kit. Results: The breeds included Mongrels (n = 2), Norfolk Terriers (n = 1), Miniature Dachshunds (n = 1), and Maltese (n = 2), and their ages were 9.3 ± 6.5 months; the bodyweight was 3.3 ± 0.8 kg. The concentration of VIP in the saphenous vein was 17.75 ± 13.88 pg/mL; in contrast, the concentration of VIP in the portal vein was 29.7 ± 20.29 pg/mL. There was no significant difference in the VIP concentration between veins. Conclusion: There was no difference in the VIP concentration between the portal and saphenous veins, suggesting non-association between VIP and the PSS, in the absence of portal hypertension.https://www.openveterinaryjournal.com/OVJ-2020-11-323%20M.%20Isaka%20and%20H.%20Ueno.pdfdogsportosystemic shuntvasoactive intestinal peptide |
| spellingShingle | Mitsuhiro Isaka Hiroshi Ueno Vasoactive intestinal peptide in canine portosystemic shunt in the absence of portal hypertension Open Veterinary Journal dogs portosystemic shunt vasoactive intestinal peptide |
| title | Vasoactive intestinal peptide in canine portosystemic shunt in the absence of portal hypertension |
| title_full | Vasoactive intestinal peptide in canine portosystemic shunt in the absence of portal hypertension |
| title_fullStr | Vasoactive intestinal peptide in canine portosystemic shunt in the absence of portal hypertension |
| title_full_unstemmed | Vasoactive intestinal peptide in canine portosystemic shunt in the absence of portal hypertension |
| title_short | Vasoactive intestinal peptide in canine portosystemic shunt in the absence of portal hypertension |
| title_sort | vasoactive intestinal peptide in canine portosystemic shunt in the absence of portal hypertension |
| topic | dogs portosystemic shunt vasoactive intestinal peptide |
| url | https://www.openveterinaryjournal.com/OVJ-2020-11-323%20M.%20Isaka%20and%20H.%20Ueno.pdf |
| work_keys_str_mv | AT mitsuhiroisaka vasoactiveintestinalpeptideincanineportosystemicshuntintheabsenceofportalhypertension AT hiroshiueno vasoactiveintestinalpeptideincanineportosystemicshuntintheabsenceofportalhypertension |