Topiramate-induced periodic limb movement disorder in a patient affected by focal epilepsy
Periodic limb movement disorder (PLMD) is characterized by pathological periodic limb movements during sleep, insomnia and/or diurnal sleepiness, and the absence of another primary sleep disorder. We report a patient with complex partial seizures who developed PLMD while taking topiramate (TPM). He...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-01-01
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| Series: | Epilepsy and Behavior Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213323214000267 |
| _version_ | 1828193003491033088 |
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| author | Andrea Romigi Giuseppe Vitrani Alfredo D'Aniello Giancarlo Di Gennaro |
| author_facet | Andrea Romigi Giuseppe Vitrani Alfredo D'Aniello Giancarlo Di Gennaro |
| author_sort | Andrea Romigi |
| collection | DOAJ |
| description | Periodic limb movement disorder (PLMD) is characterized by pathological periodic limb movements during sleep, insomnia and/or diurnal sleepiness, and the absence of another primary sleep disorder. We report a patient with complex partial seizures who developed PLMD while taking topiramate (TPM). He had no evidence of metabolic and/or other conditions inducing PLMD. He also had fragmented sleep and disruptive PLMS on polysomnography, and PLMS subsided with change of antiepileptic drug. Topiramate may modulate the dopaminergic pathway by inhibition of glutamate release, thereby inducing PLMD as observed in our patient. Although a single case does not allow any generalization, PLMD should be considered in patients complaining of insomnia and treated with TPM. |
| first_indexed | 2024-04-12T09:01:41Z |
| format | Article |
| id | doaj.art-8de0296ff09e46c38330b98938f0038e |
| institution | Directory Open Access Journal |
| issn | 2213-3232 |
| language | English |
| last_indexed | 2024-04-12T09:01:41Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Epilepsy and Behavior Case Reports |
| spelling | doaj.art-8de0296ff09e46c38330b98938f0038e2022-12-22T03:39:13ZengElsevierEpilepsy and Behavior Case Reports2213-32322014-01-012C12112310.1016/j.ebcr.2014.04.002Topiramate-induced periodic limb movement disorder in a patient affected by focal epilepsyAndrea Romigi0Giuseppe Vitrani1Alfredo D'Aniello2Giancarlo Di Gennaro3IRCCS Neuromed, Via Atinense 18, Pozzilli, IS, ItalyIRCCS Neuromed, Via Atinense 18, Pozzilli, IS, ItalyIRCCS Neuromed, Via Atinense 18, Pozzilli, IS, ItalyIRCCS Neuromed, Via Atinense 18, Pozzilli, IS, ItalyPeriodic limb movement disorder (PLMD) is characterized by pathological periodic limb movements during sleep, insomnia and/or diurnal sleepiness, and the absence of another primary sleep disorder. We report a patient with complex partial seizures who developed PLMD while taking topiramate (TPM). He had no evidence of metabolic and/or other conditions inducing PLMD. He also had fragmented sleep and disruptive PLMS on polysomnography, and PLMS subsided with change of antiepileptic drug. Topiramate may modulate the dopaminergic pathway by inhibition of glutamate release, thereby inducing PLMD as observed in our patient. Although a single case does not allow any generalization, PLMD should be considered in patients complaining of insomnia and treated with TPM.http://www.sciencedirect.com/science/article/pii/S2213323214000267TopiramateFocal epilepsyPLMDSleepSleepinessCyclic alternating pattern |
| spellingShingle | Andrea Romigi Giuseppe Vitrani Alfredo D'Aniello Giancarlo Di Gennaro Topiramate-induced periodic limb movement disorder in a patient affected by focal epilepsy Epilepsy and Behavior Case Reports Topiramate Focal epilepsy PLMD Sleep Sleepiness Cyclic alternating pattern |
| title | Topiramate-induced periodic limb movement disorder in a patient affected by focal epilepsy |
| title_full | Topiramate-induced periodic limb movement disorder in a patient affected by focal epilepsy |
| title_fullStr | Topiramate-induced periodic limb movement disorder in a patient affected by focal epilepsy |
| title_full_unstemmed | Topiramate-induced periodic limb movement disorder in a patient affected by focal epilepsy |
| title_short | Topiramate-induced periodic limb movement disorder in a patient affected by focal epilepsy |
| title_sort | topiramate induced periodic limb movement disorder in a patient affected by focal epilepsy |
| topic | Topiramate Focal epilepsy PLMD Sleep Sleepiness Cyclic alternating pattern |
| url | http://www.sciencedirect.com/science/article/pii/S2213323214000267 |
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