Central Hemodynamics in Relation to Circulating Desphospho‐Uncarboxylated Matrix Gla Protein: A Population Study
Background Stiffening and calcification of the large arteries are forerunners of cardiovascular complications. MGP (Matrix Gla protein), which requires vitamin K–dependent activation, is a potent locally acting inhibitor of arterial calcification. We hypothesized that the central hemodynamic propert...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-04-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.011960 |
| _version_ | 1811275147250761728 |
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| author | Fang‐Fei Wei Lutgarde Thijs Nicholas Cauwenberghs Wen‐Yi Yang Zhen‐Yu Zhang Cai‐Guo Yu Tatiana Kuznetsova Tim S. Nawrot Harry A. J. Struijker‐Boudier Peter Verhamme Cees Vermeer Jan A. Staessen |
| author_facet | Fang‐Fei Wei Lutgarde Thijs Nicholas Cauwenberghs Wen‐Yi Yang Zhen‐Yu Zhang Cai‐Guo Yu Tatiana Kuznetsova Tim S. Nawrot Harry A. J. Struijker‐Boudier Peter Verhamme Cees Vermeer Jan A. Staessen |
| author_sort | Fang‐Fei Wei |
| collection | DOAJ |
| description | Background Stiffening and calcification of the large arteries are forerunners of cardiovascular complications. MGP (Matrix Gla protein), which requires vitamin K–dependent activation, is a potent locally acting inhibitor of arterial calcification. We hypothesized that the central hemodynamic properties might be associated with inactive desphospho‐uncarboxylated MGP (dp‐ucMGP). Methods and Results In 835 randomly recruited Flemish individuals (mean age, 49.7 years; 45.6% women), we measured plasma dp‐ucMGP, using an ELISA‐based assay. We derived central pulse pressure and carotid‐femoral pulse wave velocity (PWV) from applanation tonometry and calculated forward and backward pulse waves using an automated, pressure‐based wave separation analysis algorithm. Aortic PWV (n=657), central pulse pressure, forward pulse wave, and backward pulse wave mean±SD values were 7.34±1.64 m/s, 45.2±15.3 mm Hg, 33.2±10.2 mm Hg, and 21.8±8.6 mm Hg, respectively. The geometric mean plasma concentration of dp‐ucMGP was 4.09 μg/L. All hemodynamic indexes increased across tertiles of dp‐ucMGP distribution. In multivariable‐adjusted analyses, a doubling of dp‐ucMGP was associated with higher PWV (0.15 m/s; 95% CI, 0.01–0.28 m/s), central pulse pressure (1.70 mm Hg; 95% CI, 0.49–2.91 mm Hg), forward pulse wave (0.93 mm Hg; 95% CI, 0.01–1.84 mm Hg), and backward pulse wave (0.71 mm Hg; 95% CI, 0.11–1.30 mm Hg). Categorization of aortic PWV by tertiles of its distribution highlighted a decreasing trend of PWV at low dp‐ucMGP (<3.35 μg/L) and an increasing trend at high dp‐ucMGP (≥5.31 μg/L). Conclusions In people representative for the general population, higher inactive dp‐ucMGP was associated with greater PWV, central pulse pressure, forward pulse wave, and backward pulse wave. These observations highlight new avenues for preserving vascular integrity and preventing cardiovascular complications (eg, by improving a person's vitamin K status). |
| first_indexed | 2024-04-12T23:32:52Z |
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| id | doaj.art-8de1ca99df0a4ce182ef9360162fefab |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-12T23:32:52Z |
| publishDate | 2019-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-8de1ca99df0a4ce182ef9360162fefab2022-12-22T03:12:14ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802019-04-018710.1161/JAHA.119.011960Central Hemodynamics in Relation to Circulating Desphospho‐Uncarboxylated Matrix Gla Protein: A Population StudyFang‐Fei Wei0Lutgarde Thijs1Nicholas Cauwenberghs2Wen‐Yi Yang3Zhen‐Yu Zhang4Cai‐Guo Yu5Tatiana Kuznetsova6Tim S. Nawrot7Harry A. J. Struijker‐Boudier8Peter Verhamme9Cees Vermeer10Jan A. Staessen11Studies Coordinating Centre Research Unit Hypertension and Cardiovascular Epidemiology Department of Cardiovascular Sciences University of Leuven BelgiumStudies Coordinating Centre Research Unit Hypertension and Cardiovascular Epidemiology Department of Cardiovascular Sciences University of Leuven BelgiumStudies Coordinating Centre Research Unit Hypertension and Cardiovascular Epidemiology Department of Cardiovascular Sciences University of Leuven BelgiumStudies Coordinating Centre Research Unit Hypertension and Cardiovascular Epidemiology Department of Cardiovascular Sciences University of Leuven BelgiumStudies Coordinating Centre Research Unit Hypertension and Cardiovascular Epidemiology Department of Cardiovascular Sciences University of Leuven BelgiumStudies Coordinating Centre Research Unit Hypertension and Cardiovascular Epidemiology Department of Cardiovascular Sciences University of Leuven BelgiumStudies Coordinating Centre Research Unit Hypertension and Cardiovascular Epidemiology Department of Cardiovascular Sciences University of Leuven BelgiumCentre for Environmental Sciences Hasselt University Diepenbeek BelgiumDepartment of Pharmacology Maastricht University Maastricht the NetherlandsCentre for Molecular and Vascular Biology Department of Cardiovascular Sciences University of Leuven Leuven BelgiumCardiovascular Research Institute Maastricht Maastricht University Maastricht the NetherlandsStudies Coordinating Centre Research Unit Hypertension and Cardiovascular Epidemiology Department of Cardiovascular Sciences University of Leuven BelgiumBackground Stiffening and calcification of the large arteries are forerunners of cardiovascular complications. MGP (Matrix Gla protein), which requires vitamin K–dependent activation, is a potent locally acting inhibitor of arterial calcification. We hypothesized that the central hemodynamic properties might be associated with inactive desphospho‐uncarboxylated MGP (dp‐ucMGP). Methods and Results In 835 randomly recruited Flemish individuals (mean age, 49.7 years; 45.6% women), we measured plasma dp‐ucMGP, using an ELISA‐based assay. We derived central pulse pressure and carotid‐femoral pulse wave velocity (PWV) from applanation tonometry and calculated forward and backward pulse waves using an automated, pressure‐based wave separation analysis algorithm. Aortic PWV (n=657), central pulse pressure, forward pulse wave, and backward pulse wave mean±SD values were 7.34±1.64 m/s, 45.2±15.3 mm Hg, 33.2±10.2 mm Hg, and 21.8±8.6 mm Hg, respectively. The geometric mean plasma concentration of dp‐ucMGP was 4.09 μg/L. All hemodynamic indexes increased across tertiles of dp‐ucMGP distribution. In multivariable‐adjusted analyses, a doubling of dp‐ucMGP was associated with higher PWV (0.15 m/s; 95% CI, 0.01–0.28 m/s), central pulse pressure (1.70 mm Hg; 95% CI, 0.49–2.91 mm Hg), forward pulse wave (0.93 mm Hg; 95% CI, 0.01–1.84 mm Hg), and backward pulse wave (0.71 mm Hg; 95% CI, 0.11–1.30 mm Hg). Categorization of aortic PWV by tertiles of its distribution highlighted a decreasing trend of PWV at low dp‐ucMGP (<3.35 μg/L) and an increasing trend at high dp‐ucMGP (≥5.31 μg/L). Conclusions In people representative for the general population, higher inactive dp‐ucMGP was associated with greater PWV, central pulse pressure, forward pulse wave, and backward pulse wave. These observations highlight new avenues for preserving vascular integrity and preventing cardiovascular complications (eg, by improving a person's vitamin K status).https://www.ahajournals.org/doi/10.1161/JAHA.119.011960aortic stiffnesscalcificationhemodynamicsmatrix proteinspulse pressure |
| spellingShingle | Fang‐Fei Wei Lutgarde Thijs Nicholas Cauwenberghs Wen‐Yi Yang Zhen‐Yu Zhang Cai‐Guo Yu Tatiana Kuznetsova Tim S. Nawrot Harry A. J. Struijker‐Boudier Peter Verhamme Cees Vermeer Jan A. Staessen Central Hemodynamics in Relation to Circulating Desphospho‐Uncarboxylated Matrix Gla Protein: A Population Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease aortic stiffness calcification hemodynamics matrix proteins pulse pressure |
| title | Central Hemodynamics in Relation to Circulating Desphospho‐Uncarboxylated Matrix Gla Protein: A Population Study |
| title_full | Central Hemodynamics in Relation to Circulating Desphospho‐Uncarboxylated Matrix Gla Protein: A Population Study |
| title_fullStr | Central Hemodynamics in Relation to Circulating Desphospho‐Uncarboxylated Matrix Gla Protein: A Population Study |
| title_full_unstemmed | Central Hemodynamics in Relation to Circulating Desphospho‐Uncarboxylated Matrix Gla Protein: A Population Study |
| title_short | Central Hemodynamics in Relation to Circulating Desphospho‐Uncarboxylated Matrix Gla Protein: A Population Study |
| title_sort | central hemodynamics in relation to circulating desphospho uncarboxylated matrix gla protein a population study |
| topic | aortic stiffness calcification hemodynamics matrix proteins pulse pressure |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.011960 |
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