Association between endometrial blood and clinical outcome in frozen single blastocyst transfer cycles
Background: The success of embryo transfer cycle depends mainly on the quality of embryo and endometrial receptivity. Ultrasound examination is still the most widely used non-invasive evaluation method for its advantages of convenience, non-invasiveness and repeatability. Ultrasound-measured endomet...
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| Format: | Article |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1113853/full |
| _version_ | 1797487916922961920 |
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| author | Qian Zhang Xiaolong Wang Zhishu Li Yinghua Wang Hai’Ou Lu Yuhong Xiao Yuexin Yu |
| author_facet | Qian Zhang Xiaolong Wang Zhishu Li Yinghua Wang Hai’Ou Lu Yuhong Xiao Yuexin Yu |
| author_sort | Qian Zhang |
| collection | DOAJ |
| description | Background: The success of embryo transfer cycle depends mainly on the quality of embryo and endometrial receptivity. Ultrasound examination is still the most widely used non-invasive evaluation method for its advantages of convenience, non-invasiveness and repeatability. Ultrasound-measured endometrial blood flow is one of the important evaluation indicators of morphology.Aims: To investigate the effect of the number of endometrial blood flow branches on pregnancy outcome of frozen-thawed embryo transfer cycles which have undergoing hormone replacement therapy (HRT-FET).Material and methods: A retrospective cohort study was performed looking at a total of 1390 HRT-FET cycles from our reproductive medicine center between January 2017 to December 2021, which transferred one blastocyst frozen on day 5 with good quality in morphology. Associations between endometrial blood flow branches and pregnancy outcomes were evaluated with multivariable linear regression analysis.Results: The number of endometrial blood flow branches was independently associated with clinical pregnancy (OR 1.10; 95% CI 1.02–1.20). After adjusting for potential confounders, the effect size (odds ratio) was 1.09 (95% CI 1.00–1.19), and the results showed that the clinical pregnancy rate and live birth rate of T2 and T3 groups were significantly higher than those in group T1 (p < 0.05). Subgroup analysis showed that a consistent association between the endometrial blood flow branches and clinical pregnancy in all subgroups.Conclusion: Our study provided evidence for the influence of endometrial blood flow on pregnancy outcomes. There may be an independent association between the number of endometrial blood flow branches and pregnancy outcomes in frozen-thawed single blastocyst transfer cycles. |
| first_indexed | 2024-03-09T23:55:36Z |
| format | Article |
| id | doaj.art-8de3bf303049466c8e43fa3751a8debe |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-09T23:55:36Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-8de3bf303049466c8e43fa3751a8debe2023-11-23T16:26:49ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-03-011410.3389/fphys.2023.11138531113853Association between endometrial blood and clinical outcome in frozen single blastocyst transfer cyclesQian Zhang0Xiaolong Wang1Zhishu Li2Yinghua Wang3Hai’Ou Lu4Yuhong Xiao5Yuexin Yu6Department of Reproductive Medicine, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang, ChinaDepartment of Reproductive Medicine, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Reproductive Medicine, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Reproductive Medicine, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Reproductive Medicine, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Reproductive Medicine, General Hospital of Northern Theater Command, Shenyang, ChinaBackground: The success of embryo transfer cycle depends mainly on the quality of embryo and endometrial receptivity. Ultrasound examination is still the most widely used non-invasive evaluation method for its advantages of convenience, non-invasiveness and repeatability. Ultrasound-measured endometrial blood flow is one of the important evaluation indicators of morphology.Aims: To investigate the effect of the number of endometrial blood flow branches on pregnancy outcome of frozen-thawed embryo transfer cycles which have undergoing hormone replacement therapy (HRT-FET).Material and methods: A retrospective cohort study was performed looking at a total of 1390 HRT-FET cycles from our reproductive medicine center between January 2017 to December 2021, which transferred one blastocyst frozen on day 5 with good quality in morphology. Associations between endometrial blood flow branches and pregnancy outcomes were evaluated with multivariable linear regression analysis.Results: The number of endometrial blood flow branches was independently associated with clinical pregnancy (OR 1.10; 95% CI 1.02–1.20). After adjusting for potential confounders, the effect size (odds ratio) was 1.09 (95% CI 1.00–1.19), and the results showed that the clinical pregnancy rate and live birth rate of T2 and T3 groups were significantly higher than those in group T1 (p < 0.05). Subgroup analysis showed that a consistent association between the endometrial blood flow branches and clinical pregnancy in all subgroups.Conclusion: Our study provided evidence for the influence of endometrial blood flow on pregnancy outcomes. There may be an independent association between the number of endometrial blood flow branches and pregnancy outcomes in frozen-thawed single blastocyst transfer cycles.https://www.frontiersin.org/articles/10.3389/fphys.2023.1113853/fullembryo transferpregnancy outcomeassisted reproductive techniqueblood supplyfrozen transfer cycles |
| spellingShingle | Qian Zhang Xiaolong Wang Zhishu Li Yinghua Wang Hai’Ou Lu Yuhong Xiao Yuexin Yu Association between endometrial blood and clinical outcome in frozen single blastocyst transfer cycles Frontiers in Physiology embryo transfer pregnancy outcome assisted reproductive technique blood supply frozen transfer cycles |
| title | Association between endometrial blood and clinical outcome in frozen single blastocyst transfer cycles |
| title_full | Association between endometrial blood and clinical outcome in frozen single blastocyst transfer cycles |
| title_fullStr | Association between endometrial blood and clinical outcome in frozen single blastocyst transfer cycles |
| title_full_unstemmed | Association between endometrial blood and clinical outcome in frozen single blastocyst transfer cycles |
| title_short | Association between endometrial blood and clinical outcome in frozen single blastocyst transfer cycles |
| title_sort | association between endometrial blood and clinical outcome in frozen single blastocyst transfer cycles |
| topic | embryo transfer pregnancy outcome assisted reproductive technique blood supply frozen transfer cycles |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1113853/full |
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