Association study of CREBRF missense variant (rs373863828:G > A; p.Arg457Gln) with levels of serum lipid profile in the Pacific populations
Background: A missense variant (rs373863828:G > A; p.Arg457Gln) of the CREBRF gene is strongly associated with a higher body mass index (BMI; kg/m2) in Polynesian populations. This variant has also been reported to be associated with lower total cholesterol in Samoans. Aim: The aim of this study...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-04-01
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| Series: | Annals of Human Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/03014460.2018.1461928 |
| _version_ | 1827818400980664320 |
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| author | Jun Ohashi Izumi Naka Takuro Furusawa Ryosuke Kimura Kazumi Natsuhara Taro Yamauchi Minato Nakazawa Takafumi Ishida Tsukasa Inaoka Yasuhiro Matsumura Ryutaro Ohtsuka |
| author_facet | Jun Ohashi Izumi Naka Takuro Furusawa Ryosuke Kimura Kazumi Natsuhara Taro Yamauchi Minato Nakazawa Takafumi Ishida Tsukasa Inaoka Yasuhiro Matsumura Ryutaro Ohtsuka |
| author_sort | Jun Ohashi |
| collection | DOAJ |
| description | Background: A missense variant (rs373863828:G > A; p.Arg457Gln) of the CREBRF gene is strongly associated with a higher body mass index (BMI; kg/m2) in Polynesian populations. This variant has also been reported to be associated with lower total cholesterol in Samoans. Aim: The aim of this study is to examine the association of rs373863828:G > A with levels of serum lipids in four Pacific populations. Methods: A total of 613 adult subjects were recruited from Tonga (Polynesians) and the Solomon Islands (Melanesians and Micronesians). Multiple regression analyses adjusted for age and sex were performed to examine the association of rs373863828 with levels of serum lipids in each population. Results: A significant association of rs373863828:G > A with lower level of HDL-cholesterol was detected in the Tonga population (β = –3.32 and p-value = 0.030). The expected change in HDL-cholesterol with respect to a single copy of the rs373863828-A allele was 3.32 mg/dL. However, the association between rs373863828-A and lower levels of HDL-cholesterol was not significant after further adjustment for BMI in the Tonga population (β = –2.32 and p-value = 0.13). Conclusions: The rs373863828-A allele may not directly affect the level of serum HDL-cholesterol independent of BMI. To confirm the present findings, association studies with large sample sizes and functional analyses are required. |
| first_indexed | 2024-03-12T00:47:12Z |
| format | Article |
| id | doaj.art-8de71df1a2d745ff8e1239b1d7b21c7e |
| institution | Directory Open Access Journal |
| issn | 0301-4460 1464-5033 |
| language | English |
| last_indexed | 2024-03-12T00:47:12Z |
| publishDate | 2018-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Human Biology |
| spelling | doaj.art-8de71df1a2d745ff8e1239b1d7b21c7e2023-09-14T15:36:10ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332018-04-0145321521910.1080/03014460.2018.14619281461928Association study of CREBRF missense variant (rs373863828:G > A; p.Arg457Gln) with levels of serum lipid profile in the Pacific populationsJun Ohashi0Izumi Naka1Takuro Furusawa2Ryosuke Kimura3Kazumi Natsuhara4Taro Yamauchi5Minato Nakazawa6Takafumi Ishida7Tsukasa Inaoka8Yasuhiro Matsumura9Ryutaro Ohtsuka10The University of TokyoThe University of TokyoKyoto UniversityUniversity of the RyukyusThe Japanese Red Cross Akita College of NursingHokkaido UniversityKobe UniversityThe University of TokyoSaga UniversityBunkyo UniversityJapan Wildlife Research CenterBackground: A missense variant (rs373863828:G > A; p.Arg457Gln) of the CREBRF gene is strongly associated with a higher body mass index (BMI; kg/m2) in Polynesian populations. This variant has also been reported to be associated with lower total cholesterol in Samoans. Aim: The aim of this study is to examine the association of rs373863828:G > A with levels of serum lipids in four Pacific populations. Methods: A total of 613 adult subjects were recruited from Tonga (Polynesians) and the Solomon Islands (Melanesians and Micronesians). Multiple regression analyses adjusted for age and sex were performed to examine the association of rs373863828 with levels of serum lipids in each population. Results: A significant association of rs373863828:G > A with lower level of HDL-cholesterol was detected in the Tonga population (β = –3.32 and p-value = 0.030). The expected change in HDL-cholesterol with respect to a single copy of the rs373863828-A allele was 3.32 mg/dL. However, the association between rs373863828-A and lower levels of HDL-cholesterol was not significant after further adjustment for BMI in the Tonga population (β = –2.32 and p-value = 0.13). Conclusions: The rs373863828-A allele may not directly affect the level of serum HDL-cholesterol independent of BMI. To confirm the present findings, association studies with large sample sizes and functional analyses are required.http://dx.doi.org/10.1080/03014460.2018.1461928crebrf missense variantlipid profilepolynesianmelanesianmicronesian |
| spellingShingle | Jun Ohashi Izumi Naka Takuro Furusawa Ryosuke Kimura Kazumi Natsuhara Taro Yamauchi Minato Nakazawa Takafumi Ishida Tsukasa Inaoka Yasuhiro Matsumura Ryutaro Ohtsuka Association study of CREBRF missense variant (rs373863828:G > A; p.Arg457Gln) with levels of serum lipid profile in the Pacific populations Annals of Human Biology crebrf missense variant lipid profile polynesian melanesian micronesian |
| title | Association study of CREBRF missense variant (rs373863828:G > A; p.Arg457Gln) with levels of serum lipid profile in the Pacific populations |
| title_full | Association study of CREBRF missense variant (rs373863828:G > A; p.Arg457Gln) with levels of serum lipid profile in the Pacific populations |
| title_fullStr | Association study of CREBRF missense variant (rs373863828:G > A; p.Arg457Gln) with levels of serum lipid profile in the Pacific populations |
| title_full_unstemmed | Association study of CREBRF missense variant (rs373863828:G > A; p.Arg457Gln) with levels of serum lipid profile in the Pacific populations |
| title_short | Association study of CREBRF missense variant (rs373863828:G > A; p.Arg457Gln) with levels of serum lipid profile in the Pacific populations |
| title_sort | association study of crebrf missense variant rs373863828 g a p arg457gln with levels of serum lipid profile in the pacific populations |
| topic | crebrf missense variant lipid profile polynesian melanesian micronesian |
| url | http://dx.doi.org/10.1080/03014460.2018.1461928 |
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