Efficacy of Human Papillomavirus Vaccines for Recalcitrant Anogenital and Oral Warts
Human papillomavirus (HPV) vaccines are preventive measures to decrease HPV infection rates. Knowledge of their efficacy as treatment options for anogenital warts (AGWs) and oral warts (OWs) is limited. To evaluate the efficacy of HPV vaccinations in recalcitrant AGWs and OWs (lesions persisting mor...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/23/7317 |
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| author | Giulia Ciccarese Astrid Herzum Gaetano Serviddio Corrado Occella Aurora Parodi Francesco Drago |
| author_facet | Giulia Ciccarese Astrid Herzum Gaetano Serviddio Corrado Occella Aurora Parodi Francesco Drago |
| author_sort | Giulia Ciccarese |
| collection | DOAJ |
| description | Human papillomavirus (HPV) vaccines are preventive measures to decrease HPV infection rates. Knowledge of their efficacy as treatment options for anogenital warts (AGWs) and oral warts (OWs) is limited. To evaluate the efficacy of HPV vaccinations in recalcitrant AGWs and OWs (lesions persisting more than 6 months despite conventional treatments), we compared a group of patients treated with standard therapies plus an HPV vaccine with a group of patients treated with standard therapies only. The response to treatment (in terms of the number of lesions) in the two groups was compared. Data were analyzed with the χ2 test and <i>p</i> values < 0.05 were considered to be statistically significant. The study included 14 patients (group A = cases) who received 3 doses of an intramuscular HPV vaccine (Gardasil 4 or Gardasil 9) in addition to the standard treatments for AGWs and OWs, and 15 age- and sex-matched patients (group B = controls) with an analogous number of lesions to group A who received only standard therapies. After 12 months, 85% of patients of group A versus 33% of group B had positive clinical outcomes (0.004). Our findings suggest a possible therapeutic role of HPV vaccines in addition to standard treatments for AGWs/OWs. Preventive vaccines, blocking the viral entry through the induction of L1-specific antibodies, can prevent autologous reinfections (through auto-inoculation) and favor the elimination of the virus. |
| first_indexed | 2024-03-09T01:49:03Z |
| format | Article |
| id | doaj.art-8de73e1ed64f46e2a19c339565e0c095 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T01:49:03Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8de73e1ed64f46e2a19c339565e0c0952023-12-08T15:19:22ZengMDPI AGJournal of Clinical Medicine2077-03832023-11-011223731710.3390/jcm12237317Efficacy of Human Papillomavirus Vaccines for Recalcitrant Anogenital and Oral WartsGiulia Ciccarese0Astrid Herzum1Gaetano Serviddio2Corrado Occella3Aurora Parodi4Francesco Drago5Unit of Dermatology, Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto 1, 71122 Foggia, ItalyDermatology Unit, IRCCS Istituto Giannina Gaslini, Via G Gaslini 5, 16147 Genova, ItalyLiver Unit, C.U.R.E. (University Centre for Liver Disease Research and Treatment), Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto 1, 71122 Foggia, ItalyDermatology Unit, IRCCS Istituto Giannina Gaslini, Via G Gaslini 5, 16147 Genova, ItalySection of Dermatology, Dipartimento di Scienze della Salute, University of Genoa, Ospedale-Policlinico San Martino, IRCCS, Largo R. Benzi, 10, 16132 Genova, ItalySection of Dermatology, Dipartimento di Scienze della Salute, University of Genoa, Ospedale-Policlinico San Martino, IRCCS, Largo R. Benzi, 10, 16132 Genova, ItalyHuman papillomavirus (HPV) vaccines are preventive measures to decrease HPV infection rates. Knowledge of their efficacy as treatment options for anogenital warts (AGWs) and oral warts (OWs) is limited. To evaluate the efficacy of HPV vaccinations in recalcitrant AGWs and OWs (lesions persisting more than 6 months despite conventional treatments), we compared a group of patients treated with standard therapies plus an HPV vaccine with a group of patients treated with standard therapies only. The response to treatment (in terms of the number of lesions) in the two groups was compared. Data were analyzed with the χ2 test and <i>p</i> values < 0.05 were considered to be statistically significant. The study included 14 patients (group A = cases) who received 3 doses of an intramuscular HPV vaccine (Gardasil 4 or Gardasil 9) in addition to the standard treatments for AGWs and OWs, and 15 age- and sex-matched patients (group B = controls) with an analogous number of lesions to group A who received only standard therapies. After 12 months, 85% of patients of group A versus 33% of group B had positive clinical outcomes (0.004). Our findings suggest a possible therapeutic role of HPV vaccines in addition to standard treatments for AGWs/OWs. Preventive vaccines, blocking the viral entry through the induction of L1-specific antibodies, can prevent autologous reinfections (through auto-inoculation) and favor the elimination of the virus.https://www.mdpi.com/2077-0383/12/23/7317human papillomavirus infectionhuman papillomavirus vaccineanogenital warts |
| spellingShingle | Giulia Ciccarese Astrid Herzum Gaetano Serviddio Corrado Occella Aurora Parodi Francesco Drago Efficacy of Human Papillomavirus Vaccines for Recalcitrant Anogenital and Oral Warts Journal of Clinical Medicine human papillomavirus infection human papillomavirus vaccine anogenital warts |
| title | Efficacy of Human Papillomavirus Vaccines for Recalcitrant Anogenital and Oral Warts |
| title_full | Efficacy of Human Papillomavirus Vaccines for Recalcitrant Anogenital and Oral Warts |
| title_fullStr | Efficacy of Human Papillomavirus Vaccines for Recalcitrant Anogenital and Oral Warts |
| title_full_unstemmed | Efficacy of Human Papillomavirus Vaccines for Recalcitrant Anogenital and Oral Warts |
| title_short | Efficacy of Human Papillomavirus Vaccines for Recalcitrant Anogenital and Oral Warts |
| title_sort | efficacy of human papillomavirus vaccines for recalcitrant anogenital and oral warts |
| topic | human papillomavirus infection human papillomavirus vaccine anogenital warts |
| url | https://www.mdpi.com/2077-0383/12/23/7317 |
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