De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals
An environmentally safe means of mosquito control is the application of Bacillus thuringiensis israelensis, which produces a cocktail of four naturally crystalline proteins exclusively toxic to mosquito. Here the authors report the atomic-resolution structures of Bti Cry11Aa and related Btj Cry11Ba...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31746-x |
| _version_ | 1818162653298688000 |
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| author | Guillaume Tetreau Michael R. Sawaya Elke De Zitter Elena A. Andreeva Anne-Sophie Banneville Natalie A. Schibrowsky Nicolas Coquelle Aaron S. Brewster Marie Luise Grünbein Gabriela Nass Kovacs Mark S. Hunter Marco Kloos Raymond G. Sierra Giorgio Schiro Pei Qiao Myriam Stricker Dennis Bideshi Iris D. Young Ninon Zala Sylvain Engilberge Alexander Gorel Luca Signor Jean-Marie Teulon Mario Hilpert Lutz Foucar Johan Bielecki Richard Bean Raphael de Wijn Tokushi Sato Henry Kirkwood Romain Letrun Alexander Batyuk Irina Snigireva Daphna Fenel Robin Schubert Ethan J. Canfield Mario M. Alba Frédéric Laporte Laurence Després Maria Bacia Amandine Roux Christian Chapelle François Riobé Olivier Maury Wai Li Ling Sébastien Boutet Adrian Mancuso Irina Gutsche Eric Girard Thomas R. M. Barends Jean-Luc Pellequer Hyun-Woo Park Arthur D. Laganowsky Jose Rodriguez Manfred Burghammer Robert L. Shoeman R. Bruce Doak Martin Weik Nicholas K. Sauter Brian Federici Duilio Cascio Ilme Schlichting Jacques-Philippe Colletier |
| author_facet | Guillaume Tetreau Michael R. Sawaya Elke De Zitter Elena A. Andreeva Anne-Sophie Banneville Natalie A. Schibrowsky Nicolas Coquelle Aaron S. Brewster Marie Luise Grünbein Gabriela Nass Kovacs Mark S. Hunter Marco Kloos Raymond G. Sierra Giorgio Schiro Pei Qiao Myriam Stricker Dennis Bideshi Iris D. Young Ninon Zala Sylvain Engilberge Alexander Gorel Luca Signor Jean-Marie Teulon Mario Hilpert Lutz Foucar Johan Bielecki Richard Bean Raphael de Wijn Tokushi Sato Henry Kirkwood Romain Letrun Alexander Batyuk Irina Snigireva Daphna Fenel Robin Schubert Ethan J. Canfield Mario M. Alba Frédéric Laporte Laurence Després Maria Bacia Amandine Roux Christian Chapelle François Riobé Olivier Maury Wai Li Ling Sébastien Boutet Adrian Mancuso Irina Gutsche Eric Girard Thomas R. M. Barends Jean-Luc Pellequer Hyun-Woo Park Arthur D. Laganowsky Jose Rodriguez Manfred Burghammer Robert L. Shoeman R. Bruce Doak Martin Weik Nicholas K. Sauter Brian Federici Duilio Cascio Ilme Schlichting Jacques-Philippe Colletier |
| author_sort | Guillaume Tetreau |
| collection | DOAJ |
| description | An environmentally safe means of mosquito control is the application of Bacillus thuringiensis israelensis, which produces a cocktail of four naturally crystalline proteins exclusively toxic to mosquito. Here the authors report the atomic-resolution structures of Bti Cry11Aa and related Btj Cry11Ba solved de novo through Serial Femtosecond Crystallography on naturally-occurring nanocrystals. |
| first_indexed | 2024-12-11T16:37:05Z |
| format | Article |
| id | doaj.art-8dead0f985474ca8a66f02736c28391a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-11T16:37:05Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8dead0f985474ca8a66f02736c28391a2022-12-22T00:58:26ZengNature PortfolioNature Communications2041-17232022-07-0113111810.1038/s41467-022-31746-xDe novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystalsGuillaume Tetreau0Michael R. Sawaya1Elke De Zitter2Elena A. Andreeva3Anne-Sophie Banneville4Natalie A. Schibrowsky5Nicolas Coquelle6Aaron S. Brewster7Marie Luise Grünbein8Gabriela Nass Kovacs9Mark S. Hunter10Marco Kloos11Raymond G. Sierra12Giorgio Schiro13Pei Qiao14Myriam Stricker15Dennis Bideshi16Iris D. Young17Ninon Zala18Sylvain Engilberge19Alexander Gorel20Luca Signor21Jean-Marie Teulon22Mario Hilpert23Lutz Foucar24Johan Bielecki25Richard Bean26Raphael de Wijn27Tokushi Sato28Henry Kirkwood29Romain Letrun30Alexander Batyuk31Irina Snigireva32Daphna Fenel33Robin Schubert34Ethan J. Canfield35Mario M. Alba36Frédéric Laporte37Laurence Després38Maria Bacia39Amandine Roux40Christian Chapelle41François Riobé42Olivier Maury43Wai Li Ling44Sébastien Boutet45Adrian Mancuso46Irina Gutsche47Eric Girard48Thomas R. M. Barends49Jean-Luc Pellequer50Hyun-Woo Park51Arthur D. Laganowsky52Jose Rodriguez53Manfred Burghammer54Robert L. Shoeman55R. Bruce Doak56Martin Weik57Nicholas K. Sauter58Brian Federici59Duilio Cascio60Ilme Schlichting61Jacques-Philippe Colletier62Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleUCLA-DOE Institute for Genomics and Proteomics, Department of Biological Chemistry, University of CaliforniaUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleUCLA-DOE Institute for Genomics and Proteomics, Department of Biological Chemistry, University of CaliforniaLarge-Scale Structures Group, Institut Laue-LangevinMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National LaboratoryMax-Planck-Institut für medizinische ForschungMax-Planck-Institut für medizinische ForschungLinac Coherent Light Source, SLAC National Accelerator LaboratoryMax-Planck-Institut für medizinische ForschungLinac Coherent Light Source, SLAC National Accelerator LaboratoryUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleDepartment of Chemistry, Texas A&M UniversityMax-Planck-Institut für medizinische ForschungDepartment of Entomology and Institute for Integrative Genome Biology, University of CaliforniaMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National LaboratoryUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleMax-Planck-Institut für medizinische ForschungUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleMax-Planck-Institut für medizinische ForschungMax-Planck-Institut für medizinische ForschungEuropean XFEL GmbHEuropean XFEL GmbHEuropean XFEL GmbHEuropean XFEL GmbHEuropean XFEL GmbHEuropean XFEL GmbHLinac Coherent Light Source, SLAC National Accelerator LaboratoryEuropean Synchrotron Radiation Facility (ESRF), BP 220Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleEuropean XFEL GmbHMass Spectrometry Core Facility, School of Pharmacy, University of Southern CaliforniaDepartment of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern CaliforniaUniv. Grenoble Alpes, CNRS, LECAUniv. Grenoble Alpes, CNRS, LECAUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleUniv. Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, Laboratoire de ChimiePolyvalan SARLUniv. Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, Laboratoire de ChimieUniv. Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, Laboratoire de ChimieUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleLinac Coherent Light Source, SLAC National Accelerator LaboratoryEuropean XFEL GmbHUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleMax-Planck-Institut für medizinische ForschungUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleDepartment of Entomology and Institute for Integrative Genome Biology, University of CaliforniaDepartment of Chemistry, Texas A&M UniversityUCLA-DOE Institute for Genomics and Proteomics, Department of Biological Chemistry, University of CaliforniaEuropean Synchrotron Radiation Facility (ESRF), BP 220Max-Planck-Institut für medizinische ForschungMax-Planck-Institut für medizinische ForschungUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National LaboratoryDepartment of Entomology and Institute for Integrative Genome Biology, University of CaliforniaUCLA-DOE Institute for Genomics and Proteomics, Department of Biological Chemistry, University of CaliforniaMax-Planck-Institut für medizinische ForschungUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie StructuraleAn environmentally safe means of mosquito control is the application of Bacillus thuringiensis israelensis, which produces a cocktail of four naturally crystalline proteins exclusively toxic to mosquito. Here the authors report the atomic-resolution structures of Bti Cry11Aa and related Btj Cry11Ba solved de novo through Serial Femtosecond Crystallography on naturally-occurring nanocrystals.https://doi.org/10.1038/s41467-022-31746-x |
| spellingShingle | Guillaume Tetreau Michael R. Sawaya Elke De Zitter Elena A. Andreeva Anne-Sophie Banneville Natalie A. Schibrowsky Nicolas Coquelle Aaron S. Brewster Marie Luise Grünbein Gabriela Nass Kovacs Mark S. Hunter Marco Kloos Raymond G. Sierra Giorgio Schiro Pei Qiao Myriam Stricker Dennis Bideshi Iris D. Young Ninon Zala Sylvain Engilberge Alexander Gorel Luca Signor Jean-Marie Teulon Mario Hilpert Lutz Foucar Johan Bielecki Richard Bean Raphael de Wijn Tokushi Sato Henry Kirkwood Romain Letrun Alexander Batyuk Irina Snigireva Daphna Fenel Robin Schubert Ethan J. Canfield Mario M. Alba Frédéric Laporte Laurence Després Maria Bacia Amandine Roux Christian Chapelle François Riobé Olivier Maury Wai Li Ling Sébastien Boutet Adrian Mancuso Irina Gutsche Eric Girard Thomas R. M. Barends Jean-Luc Pellequer Hyun-Woo Park Arthur D. Laganowsky Jose Rodriguez Manfred Burghammer Robert L. Shoeman R. Bruce Doak Martin Weik Nicholas K. Sauter Brian Federici Duilio Cascio Ilme Schlichting Jacques-Philippe Colletier De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals Nature Communications |
| title | De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals |
| title_full | De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals |
| title_fullStr | De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals |
| title_full_unstemmed | De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals |
| title_short | De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals |
| title_sort | de novo determination of mosquitocidal cry11aa and cry11ba structures from naturally occurring nanocrystals |
| url | https://doi.org/10.1038/s41467-022-31746-x |
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