Gut Microbiome and Colorectal Cancer
Colorectal cancer (CRC) is one of the most common cancers in Korea. A majority of CRCs are caused by progressive genomic alterations referred to as the adenoma-carcinoma sequence. The factors that may increase the risk of CRC include obesity and consumption of a high-fat diet, red meat, processed me...
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| Format: | Article |
| Language: | English |
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Jin Publishing & Printing Co.
2023-08-01
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| Series: | The Korean Journal of Gastroenterology |
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| Online Access: | https://www.kjg.or.kr/journal/view.html?uid=5942&vmd=Full |
| _version_ | 1797263473874305024 |
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| author | Tae-Geun Gweon |
| author_facet | Tae-Geun Gweon |
| author_sort | Tae-Geun Gweon |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the most common cancers in Korea. A majority of CRCs are caused by progressive genomic alterations referred to as the adenoma-carcinoma sequence. The factors that may increase the risk of CRC include obesity and consumption of a high-fat diet, red meat, processed meat, and alcohol. Recently, the role of gut microbiota in the formation, progression and treatment of CRCs has been investigated in depth. An altered gut microbiota can drive carcinogenesis and cause the development of CRC. Studies have also shown the role of gut microbiota in the prevention of CRC and the impact of therapies involving gut microbiota on CRC. Herein, we summarize the current understanding of the role of the gut microbiota in the development of CRC and its therapeutic potential, including the prevention of CRC and in enhancing efficacy of chemotherapy and immunotherapy. |
| first_indexed | 2024-04-25T00:13:34Z |
| format | Article |
| id | doaj.art-8dedccbd3eaa4e869afe9c658fbb68a0 |
| institution | Directory Open Access Journal |
| issn | 1598-9992 2233-6869 |
| language | English |
| last_indexed | 2024-04-25T00:13:34Z |
| publishDate | 2023-08-01 |
| publisher | Jin Publishing & Printing Co. |
| record_format | Article |
| series | The Korean Journal of Gastroenterology |
| spelling | doaj.art-8dedccbd3eaa4e869afe9c658fbb68a02024-03-13T08:15:02ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922233-68692023-08-01821566210.4166/kjg.2023.089Gut Microbiome and Colorectal CancerTae-Geun Gweon0https://orcid.org/0000-0002-0884-7228Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, KoreaColorectal cancer (CRC) is one of the most common cancers in Korea. A majority of CRCs are caused by progressive genomic alterations referred to as the adenoma-carcinoma sequence. The factors that may increase the risk of CRC include obesity and consumption of a high-fat diet, red meat, processed meat, and alcohol. Recently, the role of gut microbiota in the formation, progression and treatment of CRCs has been investigated in depth. An altered gut microbiota can drive carcinogenesis and cause the development of CRC. Studies have also shown the role of gut microbiota in the prevention of CRC and the impact of therapies involving gut microbiota on CRC. Herein, we summarize the current understanding of the role of the gut microbiota in the development of CRC and its therapeutic potential, including the prevention of CRC and in enhancing efficacy of chemotherapy and immunotherapy.https://www.kjg.or.kr/journal/view.html?uid=5942&vmd=Fullcolorectal cancermicrobiotaprobioticsfusobacterium nucleatum |
| spellingShingle | Tae-Geun Gweon Gut Microbiome and Colorectal Cancer The Korean Journal of Gastroenterology colorectal cancer microbiota probiotics fusobacterium nucleatum |
| title | Gut Microbiome and Colorectal Cancer |
| title_full | Gut Microbiome and Colorectal Cancer |
| title_fullStr | Gut Microbiome and Colorectal Cancer |
| title_full_unstemmed | Gut Microbiome and Colorectal Cancer |
| title_short | Gut Microbiome and Colorectal Cancer |
| title_sort | gut microbiome and colorectal cancer |
| topic | colorectal cancer microbiota probiotics fusobacterium nucleatum |
| url | https://www.kjg.or.kr/journal/view.html?uid=5942&vmd=Full |
| work_keys_str_mv | AT taegeungweon gutmicrobiomeandcolorectalcancer |